X Zhang

Centre for Life

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Irina Neganova

Institute of Cytology

Stuart P. Atkinson

Centro de Investigacion Principe Felipe

Matthew R. Rosengart

University of Pittsburgh Medical Center

Yingjie Tang

Wuhan University

Xianglin Yuan

Huazhong University of Science and Technology

Majlinda Lako

Newcastle University

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Newcastle University

Centre for Life

Stanford SystemX Alliance

Centro de Investigacion Principe Felipe

Stem Cell Institute

University of Newcastle Australia

University of Pittsburgh

Institute of Cytology

Russian Academy of Sciences

StemCells (United States)

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Expression and functional analysis of G1 to S regulatory components reveals an important role for CDK2 in cell cycle regulation in human embryonic stem cells

Oncogene (2008)

Irina Neganova X Zhang Stuart P. Atkinson Majlinda Lako

Cyclin-dependent kinase 6

Restriction point

Cyclin A

10.1038/onc.2008.358

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Citations (181)

CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE(CaMK) KINASE MEDIATES LPS-INDUCED TNF?? PRODUCTION

Shock (2006)

X Zhang Xianglin Yuan Yingjie Tang Matthew R. Rosengart

Objective: To demonstrate that CaMKK mediates LPSinduced TNFα production through interactions with the mitogenactivated protein kinase(MAPK) cascade Methods: RAW 264 cells were stimulated with LPS(10 ng/mL). CaMKK, CaMK I and IV were inhibited with either KN62(all CaMK), STO609(CaMKK) or with targeted siRNA. TNFα was assayed by ELISA. MAPK activation and protein knockdown was assessed by western blot. Statistical analysis was performed by ANOVA. Results: LPS-induced TNFα production was inhibited by 85% by either KN62 or STO609. CaMKK and CaMK IV siRNA inhibited cytokine production, which was significant for CaMKKb. All MAPK were activated by LPS, but only JNK phosphorylation was abrogated with STO609 inhibition of CaMKK. Conclusion: CaMKK mediates LPS-induced TNFα production, most likely through the CaMKK cascade of CaMK IV. This may also involve interactions with JNK of the MAPK family.

CAMK

10.1097/00024382-200606001-00251

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