Tae‐Jin Yoon

Gyeongsang National University Hospital

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Chang Deok Kim

Chungnam National University

Jeung‐Hoon Lee

Chungnam National University Hospital

Il Hwan Kim

Inje University Haeundae Paik Hospital

Elizabeth Mellins

Stanford University

Kyung‐Cheol Sohn

Chungnam National University

Young Lee

Ministry of Health

Young‐Joon Seo

Chungnam National University

J. A. Cowan

The Ohio State University

Young‐Ho Lee

Chungnam National University

Dae-Kyoung Choi

Chungnam National University Hospital

Cooperative Institutions

Chungnam National University

Gyeongsang National University

Seoul National University

Yonsei University

Kyung Hee University

Gyeongsang National University Hospital

Sungkyunkwan University

Stanford University

Asan Medical Center

Chungnam National University Hospital

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Contrast-enhanced Magnetic Resonance Imaging of Brain Metastases at 7.0T versus 1.5T: A Preliminary Result

Investigative Magnetic Resonance Imaging (2015)

Sun Ha Paek Jhi-Hoon Kim Sung-Hong Choi Tae‐Jin Yoon Young‐Don Son

Original Article Sun Ha Paek, Jhi-Hoon Kim, Sung-Hong Choi, Tae-Jin Yoon, Young Don Son, Dong Gyu Kim, Zang-Hee Cho, Chul-Ho Sohn Department of Neurosurgery, Seoul National University Hospital, Cancer Research Institute, Ischemic/Hypoxic Disease Institute, Seoul National University College of Medicine, Seoul, Korea Department of Radiology, Seoul National University College of Medicine, Seoul, Korea Neuroscience Research Institute, Gachon University of Medicine and Science, Incheon, Korea

10.13104/imri.2015.19.1.31

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Inhibitory effects of 1,3-thiazine derivatives on melanogenesis

Journal of Pharmacy and Pharmacology (2009)

Sang Keun Ha Mamoru Koketsu Min Jae Lee Eunjung Moon Sung‐Hoon Kim

Abstract Objectives The aim of this study was to identify a novel skin-depigmenting agent from synthetic 1,3-thiazine derivatives. Methods We investigated the inhibitory effects of six kinds of 1,3-thiazine derivative on melanogenesis by examining their effects on tyrosinase activity and melanin biosynthesis in melan-a cells and the zebrafish model. Key findings Of the six compounds, 4-hydroxy-2,6-dimethyl-5,6-dihydro-4H-1,3-thiazine (TZ-6) had the strongest anti-melanogenic effects in cultured melan-a cells (30.4% inhibition at 100 μM). In addition, TZ-6 exhibited an inhibitory effect on mushroom and cellular tyrosinase. Based on the results of Western blotting, TZ-6 reduced the expression of tyrosinase at 100 mM. Additionally, TZ-6 reduced body pigmentation and inhibited tyrosinase activity in the zebrafish model. Conclusions The results have provided useful information for the development of a skin whitening agent.

Thiazine

10.1211/jpp.61.12.0011

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Citations (8)

Interaction of HLA-DM and HLA-DQ2 in antigen presentation: Implications for celiac disease association

Molecular Immunology (2012)

Tieying Hou Shuo‐Wang Qiao Xi Jin John Sidney Ludvig M. Sollid

Presentation (obstetrics)

Association (psychology)

10.1016/j.molimm.2012.03.005

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Concurrence of Stevens-Johnson Syndrome and Bilateral Parotitis after Minocycline Therapy

Case Reports in Dermatology (2010)

Jimi Yoon Seung Hun Lee Il Hwan Kim Deok-Jin Choi Jin-Pyeong Kim

Minocycline is an antibiotic of tetracycline derivatives that is commonly used in the treatment of moderate to severe acne vulgaris. It has been reported to cause rare adverse events from mild cutaneous eruption to severe forms including drug-induced lupus, serum sickness-like reaction, and hypersensitivity reactions, etc. The risks of adverse events attributed to minocycline have not been ascertained reliably and there are concerns about the safety of minocycline which could possibly result in life-threatening events such as the Stevens-Johnson syndrome. Here we demonstrate an unusual case of Stevens-Johnson syndrome in conjunction with bilateral parotitis after the intake of minocycline in a Korean boy suggesting discreet use of the drug.

Minocycline

Parotitis

10.1159/000314952

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Citations (8)

Interaction of HLA-DM and HLA-DQ2 in antigen presentation: Implications for celiac disease association

Molecular Immunology (2012)

Tieying Hou Shuo‐Wang Qiao Xi Jin John Sidney Ludvig M. Sollid

Gliadin

Tissue transglutaminase

Deamidation

10.1016/j.molimm.2012.02.115

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Citations (0)

A Case of Vulvar Melanosis

Annals of Dermatology (1996)

Byeong-Song Lee Tae‐Jin Yoon Chee‐Won Oh Tae‐Heung Kim

Melanosis

10.5021/ad.1996.8.4.275

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Photoprotective Effects of Methoxycinnamidopropyl Polysilsesquioxane

Photochemistry and Photobiology (2011)

Dae‐Kyoung Choi Taek Kyu Jung Tae‐Yeon Lim T. H. Kim Young Baek Kim

Abstract A new sunscreen ingredient, methoxycinnamidopropyl polysilsesquioxane (MCP‐PSQ), which contains an UV‐absorbing p ‐methoxycinnamoyl group, has been developed synthetically and evaluated using in vitro and in vivo approaches. Previous studies revealed that MCP‐PSQ has a raising or boosting effect on the sun protection factor (SPF) of other sunscreen agents. In this study, we demonstrated that MCP‐PSQ, an organic/inorganic hybrid compound, has photoprotective effects for human fibroblasts, and for hairless mouse and human skin. MCP‐PSQ increases cell viability and suppresses the expression of p53 protein in fibroblasts after UV exposure. In addition, the numbers of sunburn cells and mast cells are reduced by topical application of MCP‐PSQ on hairless mouse skin after UV irradiation. A 10% MCP‐PSQ cream has higher and similar effects on SPF values for human skin compared to 5% titanium dioxide (TiO 2 ) and 5% ethylhexyl methoxycinnamate (EHMC), respectively. The SPF value obtained using the MCP‐PSQ cream did not drop after UV irradiation of the cream itself. However, higher dose of UV irradiation is required to guarantee the stability or photostability of the formulation. Further, there were no side effects such as erythema, edema, itch or tingling, suggesting that MCP‐PSQ is a good sunscreen agent.

10.1111/j.1751-1097.2011.00940.x

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Citations (2)

Phototoxicity of oriental medicinal plants: measurement and possible applications.

PubMed (2011)

Ki‐Min Bark Young‐Woo Sun Tae‐Jin Yoon Il Hwan Kim

Phototoxicity can be either harmful and induce adverse skin reactions or beneficial and be used therapeutically as in psoralen and UV-A or photodynamic therapy. Hundreds of medicinal plants are widely used in Asia and Western countries in oriental medicine, yet the phototoxicity of oriental medicinal plants is an understudied area. In this contribution, the authors discuss some methods used to measure the phototoxicity of plants and give an overview of the results of their previous and ongoing studies into the phototoxicity of medicinal plants. The authors argue that because they found that more than a quarter of oriental medicinal plants can be phototoxic, such research is helpful for dermatologists and that active phototoxic components extracted from oriental medicinal plants may be used therapeutically.

Phototoxicity

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A Case of Recurrent Clear Cell Hidradenoma

Linchuang pifuke zazhi (2007)

Sung‐Min Kim Sang‐Young Park Tae‐Jin Yoon

Hidradenoma

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Effect of ginseng saponins on the growth of cultured haman keratinocyte and melanocyte