Kambiz Dowlatshahi

East Carolina University

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Adam Dickler

Little Company of Mary Hospital

Ming Fan

Hangzhou Dianzi University

Darius Francescatti

Rush University Medical Center

Kenneth J. Bloom

Ambry Genetics (United States)

Howard C. Snider

Baptist Medical Center Jacksonville

M. Kirk

Newcastle upon Tyne Hospitals NHS Foundation Trust

Michael C. Kirk

Massachusetts General Hospital

Rosalinda Alvarado

Rush University Medical Center

Peter M. Jokich

Imaging Center

David B. Skinner

University of Cambridge

Cooperative Institutions

Rush University Medical Center

Presbyterian St. Luke's Medical Center

University of Chicago

Rush University

Northwestern University

American College of Surgeons

Memorial Sloan Kettering Cancer Center

University of Illinois Chicago

Johns Hopkins University

The University of Texas MD Anderson Cancer Center

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Interstitial Laser Therapy of Breast Fibroadenomas With 6 and 8 Year Follow-Up

The Breast Journal (2009)

Kambiz Dowlatshahi Sulochana Wadhwani Rosalinda Alvarado Carlos Hidalgo Valadéz Janice J. Dieschbourg

Fibroadenomas are non-cancerous breast tumors commonly seen in teenagers but also found in women at the time of first mammogram. They have distinct physical findings and imaging features but the definitive diagnosis is made by ultrasound or stereotactic guided needle biopsy. Treatment options are observation or surgical removal. Recently, removal by ultrasound-guided technique has been reported. Alternatively, the tumor may be ablated within the breast by cold (cryotherapy) or by heat (laser, radiofrequency, focused ultrasound and microwave). In this paper the laser treatment in two patients, one with bilateral fibroadenomas, with 6 and 8 year follow-up is presented.

Cryotherapy

Breast ultrasound

Breast Fibroadenoma

10.1111/j.1524-4741.2009.00830.x

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Citations (28)

Thermal ablation of the goat mammary gland as a model for post-lumpectomy treatment of breast cancer: Preliminary observations

International Journal of Hyperthermia (2009)

Rosalinda Alvarado Brett Mahon Carlos Hidalgo Valadéz Mark J. Caufield Sulochana Wadhwani

Background. Partial breast irradiation post-lumpectomy, with a balloon bearing a radioactive source in its center, is practiced as an alternative to whole breast irradiation in the treatment of breast cancer. The goal is to ablate residual malignant cells within 1 cm radius of the resected lumpectomy margin. We hypothesize that this goal may be achieved with a fluid-filled heated balloon.Methods. Nubian-cross goats were treated under general anesthesia. The two mammary glands were sequentially bisected and a non-inflated balloon with a heating element was placed in the center of the gland which was re-sutured. Two series of experiments were conducted. In the first 22 goats (44 glands), the balloon was inflated with 5% dextrose to a pressure of 150 mmHg and heated at 87°C over selected time intervals of 1–24 minutes. In the second series (16 glands), the re-programmed device operated at 50–80 mmHg over selected time intervals of 5–20 minutes. The depth of necrosis was histologically determined after sacrificing the goats and excising the glands.Results. In the first series, glandular necrosis was noted to extend to a depth of 3.2–9.6 mm for the above heating cycles. Corresponding figures for the second series ranged from 4.7–8.6 mm for treatment times of one minute ‘warm up’ to 20 minutes of heating at 90°C. The animals exhibited no systemic side effects post-treatment.Conclusion. An experimental model describing a thermal technique causing necrosis of the goat mammary gland is described.

Lumpectomy

10.1080/02656730802322946

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Nonpalpable breast tumors: diagnosis with stereotaxic localization and fine-needle aspiration.

Radiology (1989)

Kambiz Dowlatshahi H.-J. Gent Robert A. Schmidt Peter M. Jokich Marluce Bibbo

Modern mammography is the most effective means of detecting nonpalpable breast cancers, but correct diagnosis for malignancy is made in only 20%-30% of the cases. The conventional method of lesion localization usually results in approximate placement of the hookwire in the breast. The authors report the results of stereotaxic localization, combined with fine-needle aspiration and cytologic study, performed in 528 cases. Clinically occult breast lesions were localized precisely (within 2 mm 96% of the time), sampled by means of a 23-gauge needle, and marked with either methylene blue or a hookwire for subsequent open excisional biopsy. The results indicate a sensitivity of 95%, specificity of 91%, and accuracy of 92% for the fine-needle aspiration procedure. This technique offers a significantly improved preoperative method of diagnosing small breast lesions with minimal pain, no complications, reduced cost, and no disfigurement or scar interfering with subsequent mammographic follow-up.

Occult

10.1148/radiology.170.2.2643141

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A prospective study of double diagnosis of nonpalpable lesions of the breast.

PubMed (1991)

Kambiz Dowlatshahi Jokich Pm Kluskens Lf Ronak Patel Economou Sg

Approximately three-fourths of open biopsies of the breast performed for mammographically detected suspicious lesions are shown histologically to be benign. Under the narrow conditions described herein, stereotaxic fine-needle aspiration (FNA) can identify these lesions with an accuracy of more than 90 per cent and a false-negative rate of 5 per cent. In an effort to reduce this failure rate, the mammographic appearance and stereotaxic FNA results of these lesions each were given scores on a scale of zero (benign) to five (malignant), to derive an over-all risk score prospectively applied to 264 suspicious occult lesions of the breast prior to open, biopsy. While all 264 lesions could be assigned a mammographic score, adequate tissue for assignment of a cytologic score could be obtained from 150 lesions. Of the 150 evaluable lesions, 53 were malignant and 97 were benign, historically. With a total score of two as the threshold for open biopsy, 21 of 150 (14 per cent) were proved to be benign, with no false-negative findings. If the total threshold score mandating an open biopsy was raised to four, the comparable figures were 61 of 150 (40 per cent) benign lesions and two false-negative instances of carcinoma in situ. Provided adequate tissue is aspirated for cytologic examination, we conclude that this algorithm has practical value in the management of nonpalpable lesions of the breast in that it can reliably identify a fraction of the benign lesions and spare these patients an operation.

Occult

Open biopsy

Breast carcinoma

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Immunoregulatory Properties of Human Esophageal Tumor Extract

The Journal of Immunology (1979)

Nahid Mohagheghpour Behnaz Parhami Kambiz Dowlatshahi Dara Kadjehnouri John H. Elder

Abstract Noncytotoxic aqueous extracts of esophageal tumors (TEx) inhibit the spontaneous uptake of 3H-thymidine by human peripheral blood mononuclear cells (PBM). TEx also inhibits mitogen- and antigen-induced PBM blastogenesis, mitogenesis, 3H-thymidine uptake, and 3H-leucine incorporation. Inhibition is reversible and is mediated by a heat-labile protein with a m.w. of approximately 70 to 80,000 daltons. Inhibitory activity is not due to trivial binding of mitogen or nucleotide by the inhibitor, nor is it entirely tumor specific since similar but quantitatively less activity is extractable from adjacent normal esophageal mucosa. Assorted cell surface membrane phenomena such as contact inhibition of in vitro endothelial cell proliferation, lymphocyte E rosette formation, and cap formation are unaffected by TEx. In contrast, immunoglobulin synthesis by pokeweed mitogen-stimulated PBM is enhanced by TEx. The potential importance of the local production of immunoregulatory agents like TEx in the immunologic control of tumor cell growth is discussed.

Pokeweed mitogen

Thymidine

10.4049/jimmunol.122.4.1350

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Steroids, Thiamine and Ascorbic Acid Supplementation in Septic Shock

Jennifer Stahl L. G. Robertson Kambiz Dowlatshahi Joseph Quinn Kori L. Brewer

10.1164/ajrccm-conference.2021.203.1_meetingabstracts.a2746

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Initial Clinical Results with the Mammosite Breast Brachytherapy Applicator in Women with Early-Stage Breast Cancer

International Journal of Radiation Oncology*Biology*Physics (2005)