Abstract Background & Aims Hepatic fat content can be non‐invasively estimated by controlled attenuation parameter (CAP) during transient elastography. The aim of this study was to examine the determinants and predictors of CAP values in individuals with metabolic dysfunction. Methods We enrolled 1230 consecutive apparently healthy individuals (Liver‐Bible‐2022 cohort) with ≥3 metabolic dysfunction features. CAP was measured by Fibroscan. CAP determinants and predictors were identified using backward stepwise analysis and introduced in generalized linear models. Results Participants were predominantly males (82.9%), mean age was 53.8 ± 6.4 years, 600 (48.8%) had steatosis (CAP ≥ 275 dB/m), and 27 had liver stiffness measurement (LSM) ≥ 8 kPa. CAP values correlated with LSM ( p < 10 −22 ). In multivariable analysis, fasting insulin and abdominal circumference (AC) were the main determinants of CAP ( p < 10 −6 ), together with body mass index (BMI; p < 10 −4 ), age, diabetes, triglycerides, ferritin, and lower HDL and thyroid stimulating hormone (TSH; p < 0.05 for all). In a subset of 592 participants with thyroid hormone measurement, we found an association between higher free triiodothyronine levels, correlating with lower TSH, and CAP values, independent of TSH and of levothyroxine treatment ( p = 0.0025). A clinical CAP score based on age, BMI, AC, HbA1c, ALT, and HDL predicted CAP ≥ 275 dB/m with moderate accuracy (AUROC = 0.73), which was better than that of the Fatty Liver Index and of ALT (AUROC = 0.70/0.61, respectively) and validated it in multiple cohorts. Conclusion Abdominal adiposity and insulin resistance severity were the main determinants of CAP in individuals with metabolic dysfunction and may improve steatotic liver disease risk stratification. CAP values were modulated by the hypophysis‐thyroid axis.

Transient elastography

Levothyroxine

Steatosis

10.1002/ueg2.12513

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Citations (7)

Extrapulmonary tuberculosis: an unusual presentation in an immunocompetent patient

BMJ Case Reports (2015)

Rosa Lombardi Serena Pelusi Lorena Airaghi Silvia Fargion

A 50-year-old Brazilian woman was admitted to our department because of pelvic pain irradiated to the lower left limb, ipsilateral ankle swelling and progressive weight loss. Doppler ultrasound demonstrated deep venous femoropopliteal thrombosis, while a thorax–abdomen CT scan showed multiple solid hypodense pulmonary lesions, a large hypodense lesion in the iliopsoas muscles bilaterally and a complex cystoid lesion at the hepatic hilum. These findings were better characterised as active inflammatory colliquated lymph nodes by positron emission tomography and echo-guided percutaneous fine-needle aspiration of the left iliopsoas abscessual lesion finally allowed the diagnosis of tubercular infection with positive cultures for Mycobacterium tuberculosis complex.

Iliopsoas

10.1136/bcr-2014-207146

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Citations (7)

MetSCORE: a molecular metric to evaluate the risk of metabolic syndrome based on serum NMR metabolomics

Cardiovascular Diabetology (2024)

Rubén Gil‐Redondo Ricardo Conde Chiara Bruzzone María Luisa Seco Maider Bizkarguenaga

Metabolic syndrome (MetS) is a cluster of medical conditions and risk factors correlating with insulin resistance that increase the risk of developing cardiometabolic health problems. The specific criteria for diagnosing MetS vary among different medical organizations but are typically based on the evaluation of abdominal obesity, high blood pressure, hyperglycemia, and dyslipidemia. A unique, quantitative and independent estimation of the risk of MetS based only on quantitative biomarkers is highly desirable for the comparison between patients and to study the individual progression of the disease in a quantitative manner.

Dyslipidemia

Abdominal obesity

Angiology

Atherosclerotic cardiovascular disease

10.1186/s12933-024-02363-3

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Liver function tests do not predict liver damage in diabetes. Analysis of liver steatosis and fibrosis by transient elastography in routine diabetes care

Digestive and Liver Disease (2018)

Rosa Lombardi Lorena Airaghi V. Borroni C. Bertelli L. Burdick

Transient elastography

Steatosis

Liver disease

10.1016/j.dld.2018.01.069

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