M. Amirrad

Kuwait University

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T. Saji

Kuwait University

J.T. Anim

Korle Bu Teaching Hospital

Fahd Al‐Mulla

Dasman Diabetes Institute

Ali Ibrahim

Africa Rice Center

Fayaz A. Chishti

Awadh Alanazi

Al Jouf University

Mona A. Fouda

Mohamed Moussa

University of Geneva

Mohamed M.F. Fathalla

Damietta University

Riyad Tarazi

Kuwait Cancer Control Center

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Kuwait University

Ministry of Health

Mubarak Al Kabeer Hospital

Chest Diseases Hospital

Heidelberg University

University Hospital Heidelberg

Amiri Hospital

King Saud University

Al-Sabah Hospital

Ministry of Health

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BRCA1 Gene Expression in Breast Cancer in Kuwait: Correlation with Prognostic Parameters

Medical Principles and Practice (2005)

M. Amirrad Fahd Al‐Mulla Govindarajulu Varadharaj B. John T. Saji

Objectives: This study assessed the BRCA1 gene expression in breast cancer in Kuwait, and compared it with other known prognostic factors for the disease. Materials and Methods: Forty-eight random samples of archival paraffin-embedded breast cancer tissues were studied for BRCA1 gene expression. Immunohistochemical method utilizing antibodies against different epitopes on the BRCA1 protein was used to study BRCA1 protein expression. In addition, for 29 patients, reverse transcription-polymerase chain reaction was used to detect BRCA1 mRNA expression. BRCA1 expression was correlated with age, histological type and grade of breast cancer, estrogen and progesterone receptor status, and C-erbB-2 expression. Results: No demonstrable BRCA1 mRNA and protein expression was found in 79 and 83% of the breast cancer tissues, respectively. A positive relationship was demonstrated between lack of BRCA1 (mRNA and protein) expression and high histological grade, negative estrogen and progesterone receptor status, and overexpression of C-erbB-2 in the breast cancer tissues. Conclusions: The study demonstrated lack of BRCA1 gene expression (mRNA and protein) in the majority of breast cancers in Kuwait and confirmed the inverse relationship between BRCA1 expression and parameters that determine poor prognosis in breast cancer.

Progesterone receptor

10.1159/000083913

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Medical Principles and Practice (2005)

Shahid Aziz Mona A. Fouda Axel Haecker G. Riedasch S. Langbein

10.1159/000084682

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