Ana Lúcia da Costa Darini

Universidade de São Paulo

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Leonardo Neves Andrade

Universidade de São Paulo

Joseane Cristina Ferreira

Universidade de São Paulo

Izabel Cristina Vanzato Palazzo

Universidade de São Paulo

Renata Galetti

Universidade de São Paulo

Luciene Andrade da Rocha Minarini

Universidade Federal de São Paulo

Roberto Martínez

Universidade de Ribeirão Preto

G.V. Carbonell

Instituto Adolfo Lutz

Rafael Antonio Casarin Penha Filho

Universidade Estadual Paulista (Unesp)

Ilana Lopes Baratella da Cunha Camargo

Universidade Federal de São Carlos

Eduardo Carneiro Clímaco

Universidade de Ribeirão Preto

Cooperative Institutions

Universidade de São Paulo

145

Universidade de Ribeirão Preto

Clinics Hospital of Ribeirão Preto

Instituto Adolfo Lutz

Universidade Estadual de Campinas (UNICAMP)

Universidade Brasil

SUPERA Park of Innovation and Technology of Ribeirão Preto

Universidade Estadual Paulista (Unesp)

Instituto de Ciências Farmacêuticas

Universidade Federal de Uberlândia

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Estudos preliminares indicam Enterococcus raffinosus resistente à vancomicina isolado de colonização em paciente hospitalizado com a presença dos genes vanA e esp

Resumos (2011)

Hernan Franco Romera Fazzio Caio Pontes Rezende Rafaela Francini Corrêa Hyllo Baeta Marcello Júnior Ana Lúcia da Costa Darini

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Prevalence and characterization of Enterococcus spp. from Brazilian foods

Bruna C. Gomes C. Esteves Izabel Cristina Vanzato Palazzo Ana Lúcia da Costa Darini Giovanna E. Felis

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Leukotriene B4 is essential for lung host defence and alpha-defensin-1 production during Achromobacter xylosoxidans infection

Scientific Reports (2017)

Morgana Kelly Borges Prado Gisele Aparecida Locachevic Karina Furlani Zoccal Francisco Wanderley Garcia Paula‐Silva Caroline Fontanari

Abstract Leukotriene B 4 (LTB 4 ) is essential for host immune defence. It increases neutrophil recruitment, phagocytosis and pathogen clearance, and decreases oedema and inflammasome activation. The host response and the role of LTB 4 during Achromobacter xylosoxidans infection remain unexplored. Wild-type (129 sv ) and LTB 4 deficient ( Alox5 −/− ) mice were intratracheally infected with A. xylosoxidans . Wild-type 129 sv infected mice survived beyond the 8 th day post-infection, exhibited increased levels of LTB 4 in the lung on the 1 st day, while levels of PGE 2 increased on the 7 th day post-infection. Infected Alox5 −/− mice showed impaired bacterial clearance, increased lung inflammation, and succumbed to the infection by the 7 th day. We found that exogenous LTB 4 does not affect the phagocytosis of A. xylosoxidans by alveolar macrophages in vitro . However, treatment of infected animals with LTB 4 protected from mortality, by reducing the bacterial load and inflammation via BLT 1 signalling, the high affinity receptor for LTB 4 . Of importance, we uncovered that LTB 4 induces gene and protein expression of α-defensin-1 during the infection. This molecule is essential for bacterial clearance and exhibits potent antimicrobial activity by disrupting A. xylosoxidans cell wall. Taken together, our data demonstrate a major role for LTB 4 on the control of A. xylosoxidans infection.

Achromobacter xylosoxidans

Leukotriene B4

10.1038/s41598-017-17993-9

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Citations (20)

Effects of the Movement of Insertion Sequences on the Structure of VanA Glycopeptide Resistance Elements in Enterococcus faecium

Antimicrobial Agents and Chemotherapy (2000)

Ana Lúcia da Costa Darini Marie-France I. Palepou Neil Woodford

A Tn1546-related element with IS1216V at position 8839 underwent a structural change after storage of the host strain of Enterococcus faecium at 4 degrees C. The element acquired IS1542 at position 3932, nucleotides 8732 to 8831 were deleted, and the first 3417 nucleotides were lost and replaced by an inverted copy of the IS1216V-vanY-vanZ-inverted-repeat block from the 3' end. Insertion sequence movement is likely to play a key role in the evolution of VanA resistance elements.

Enterococcus faecium

Insertion sequence

Gram-positive bacterial infections

10.1128/aac.44.5.1362-1364.2000

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Citations (33)

Virulence factors in vancomycin-resistant and vancomycin- susceptible Enterococcus faecalis from Brazil.

PubMed (2008)

Ilana Lopes Baratella da Cunha Camargo Rosemeire Cobo Zanella Michael S. Gilmore Ana Lúcia da Costa Darini

Enterococcus faecalis

Virulence factor

10.1590/s1517-838220080002000014