Aleemuddin Nm

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Sarwat Fatima

Deccan College of Medical Sciences

Syed Amer Ali

Schlumberger (British Virgin Islands)

Fahmeena Samreen

Shaik Ayub Basha

Shagufta Naaz

All India Institute of Medical Sciences

Syeda Zuleqa Unnisa

Shaik Arshad

Sumayya Samreen

Cooperative Institutions

Deccan College of Medical Sciences

Hong Kong Baptist University

Institute of Medical Sciences

National Health Service

Kowloon Hospital

University of Hong Kong

Dr. NTR University of Health Sciences

Hong Kong Polytechnic University

Aga Khan University

Schlumberger (British Virgin Islands)

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Prevalence of nontuberculous Mycobacterial infection in Non-HIV subjects of clinically presumed tuberculosis at a tertiary care center, Hyderabad

IP International Journal of Medical Microbiology and Tropical Diseases (2019)

Sarwat Fatima Aleemuddin Nm

Introduction: Tuberculosis continues to be the leading cause of morbidity and mortality in developing nations. Off late infections due to mycobacterial species other than tubercle bacilli are being reported frequently. Nontuberculous mycobacteria are being increasingly recognized and isolated as pathogens from immunocompetent host too. They are found in both pulmonary and extrapulmonary form of disease. The prevalence of infections due to NTM is known to vary with place, host and climatic factors. Aim: the present study is a retrospective cross-sectional observational study for a period of two years from Jan.2013- Dec.2014, at Princess Era Hospital,a teaching hospital of Deccan college of medical sciences at Hyderabad. Data from microbiology lab records was retrieved and analysed. Materials and Methods: about 232 specimens from 229 patients with clinical symptoms of tuberculosis were analysed for laboratory diagnosis of nontuberculosis mycobacterial infection in mycobacteriology section of microbiology laboratory. Seventy nine samples were obtained from 78 patients with pulmonary form of disease and 153 samples were from 151 patients with extrapulmonary form of disease. Study was approved by ethical committee of the college and patient consent was obtained prior to sample collection. All the specimens received in the laboratory were processed by direct microscopy for acid fast bacilli using Ziehl Neelsen stain. Culture was performed on conventional LJ media and Middle Brook 7H12 media in MGIT 320 automated system. Identification of culture positive isolates was achieved by standard biochemical test and rapid immunochromatography test for detection of mycobacterial tuberculosis protein 64 antigen [MPT64]. Results: Direct microscopy was positive in 20.52%. and 4.25% of which were later identified as NTM. Culture yielded positive result in 22.27% of the subjects. NTM were isolated in 3.49% of the total subjects studied. Mycobacterium tuberculosis was the most common

Nontuberculous Mycobacteria

Medical microbiology

Clinical Microbiology

10.18231/j.ijmmtd.2019.025

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Medication therapy management services and pharmacovigilance studies in tuberculosis patients: A patient care aspect in the pulmonology department in a Tertiary Care Hospital

International Journal of Medical Research & Health Sciences (2019)

Sumayya Samreen Shaik Ayub Basha Aleemuddin Nm Shagufta Naaz Shaik Arshad

Background: Tuberculosis is fundamentally a disease of the lungs, however, it can influence any organ in the body. Objectives: Primary objective was to improve the patient compliance or medication adherence and to identify, detect, monitor ADRs induced by anti-tubercular drugs and report them. A secondary objective was to prevent the emergence of drug resistance and treatment of prolongation/failure in TB patients. Methods: A prospective, observational, cohort study was carried out for 6-months in tertiary care hospital. There were 60 patients included in the study. The data were evaluated for patients’ demographic profile, type of TB, medication adherence and occurrence of ADRs. Adverse drug reactions were observed and recorded. The causality of ADRs was assessed using WHO-causality assessment scale and Naranjo causality assessment scale. The severity of ADRs was determined using Hartwig’s severity assessment scale. Results and Discussion: Total of 60 patients were included in the study. Results showed that among 60 patients included in the study, 44 patients experienced ADRs. Among all age groups, the highest numbers of ADRs were seen in the age group 19-30 (43.1%) years. The occurrence of ADRs was noticed more in females (77.7%). The majority of ADRs occurred in patients was general (28.4%), and gastrointestinal effects (23.8%). Conclusion and Scope of the Study: Adherence to treatment is crucial for the cure of individual patients, controlling the spread of infection, minimizing the development of drug resistance and to reduce the chances of re-infection. Proper therapeutic monitoring of regimen, dose management, and pharmacovigilance activities are necessary. Such approaches will not only improve the treatment outcomes but also minimizes the chances of treatment prolongation/failure. All the health care professionals should interpret their responsibility in this domain of the health care profession.

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