Abdulraof Almahfouz

King Faisal Specialist Hospital & Research Centre

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Mohammed Ahmed

University of East Anglia

Hussein Raef

King Faisal Specialist Hospital & Research Centre

Abdullah Alarifi

King Faisal Specialist Hospital & Research Centre

Ali S. Alzahrani

King Faisal Specialist Hospital & Research Centre

Haroon Faraz

Hackensack University Medical Center

Fouad Al‐Dayel

King Faisal Specialist Hospital & Research Centre

Robert J. Smith

Children's Hospital of Philadelphia

Saif S. Al-Sobhi

King Faisal Specialist Hospital & Research Centre

Roua A. Al‐Rijjal

King Faisal Specialist Hospital & Research Centre

Ranjit S. Parhar

King Faisal Specialist Hospital & Research Centre

Cooperative Institutions

King Faisal Specialist Hospital & Research Centre

Alfaisal University

European Atherosclerosis Society

King Fahd Security College

Harvard University

National Institutes of Health

King Abdullah International Medical Research Center

National Guard Health Affairs

Cedars-Sinai Medical Center

Joslin Diabetes Center

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Renal Metastases From Thyroid Cancer Masquerading as Renal Angiomyolipoma on Ultrasonography

Journal of Ultrasound in Medicine (2006)

Mohammed Ahmed Muhammad Zeeshan Aslam Javed Ahmed Haroon Faraz Abdulraof Almahfouz

General hospital

10.7863/jum.2006.25.11.1459

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Citations (11)

A Case Report of Hypoglycemia Due to Late Dumping Syndrome After Jejunostomy Tube Insertion

Cureus (2020)

Usamah Elalem Abdulraof Almahfouz Abdulrahman Alfadhel Abdulaziz Almohamedi Ibrahim Bin Ahmed

Dumping syndrome occurs when food moves to the small bowel faster than usual. Patients can report a variety of symptoms such as abdominal cramps, weakness, flushing, shakiness, and decreased consciousness. Dumping syndrome can be divided into early and late based on the onset of the symptoms after the ingestion of a meal. In the literature, cases of dumping syndrome have been reported, but rarely after jejunostomy tube insertion. We report a case of an 86-year-old female suffering from late dumping syndrome after jejunostomy tube placement. An 86-year-old Saudi female presented with decreased oral intake and gastrostomy tube placement was decided. Later, the multi-disciplinary team agreed to switch her to jejunostomy tube after she developed a couple of complications in the site of insertion. However, she developed hypoglycemia due to late dumping syndrome, which was managed with the addition of starch and switching her back to a gastrostomy tube feeding.

Jejunostomy

Dumping syndrome

Feeding tube

10.7759/cureus.6897

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Citations (3)

A randomized clinical trial comparing two levothyroxine regimens during Ramadan fasting in thyroidectomized patients

Journal of the Endocrine Society (2024)

Ali S. Alzahrani Noha Mukhtar Zahrah Abbas Alhammad Lulu Abdulaziz Alobaid Abdulrhman Jaber Hakami

Abstract Context For Muslim patients on levothyroxine (L-T4) therapy, the best approach for L-T4 intake during Ramadan fasting remains unclear. Objective We compared 2 practical approaches for L-T4 intake during Ramadan. Methods We randomly assigned 69 patients (21 males, 48 females, median age 44 years) with differentiated thyroid cancer (DTC) who underwent thyroidectomy in the past and are on stable LT4 doses to 2 arms. Arm A (33 patients) ingested their pre-Ramadan L-T4 dose at the evening meal and ate immediately. Arm B (36 patients) increased their pre-Ramadan dose by 25 µg if their regular L-T4 dose was ≤150 µg/day or by 50 µg if their pre-Ramadan dose was >150 µg/day and ate immediately. Results At the beginning of Ramadan (baseline), the median thyrotropin (TSH) level and the numbers of patients in euthyroidism, subclinical hyperthyroidism (Shyper), or subclinical hypothyroidism (Shypo) were comparable between the 2 arms (P = .69 and P = .65, respectively). At the end of Ramadan, in arm A there were 17 (51.5%), 3 (9.1%), and 13 (39.4%) patients in euthyroidism, Shyper, and Shypo compared with 17 (47.2%), 14 (38.9%), and 5 (13.9%) patients, respectively, in arm B (P = .005). The mean ± SD TSH levels in arms A and B at the end of Ramadan were 5.6 ± 6.0 mU/L and 1.67 ± 2.6 mU/L, respectively (P = .0001). Conclusion No overt thyroid dysfunction developed but there were more cases of Shypo in arm A and Shyper in arm B. Arm B achieved desirable levels of TSH (normal or slightly suppressed) in 86% of cases and might be a preferable approach, especially for patients who need TSH suppression (eg, DTC).

Levothyroxine

10.1210/jendso/bvae173

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A Novel Biallelic Mutation in the Insulin Binding Domain of the Insulin Receptor Causing Severe Insulin Resistance Syndrome in Five Unrelated Saudi Families; a Possible Founder Mutation.

Posters XI (2010)

Ali S. Alzahrani Minjing Zou Nora Alkahtani John Kamartey Essa Y. Baitei

10.1210/endo-meetings.2010.part3.p11.p3-547

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Abstract #128: CA-125 Glycoprotein Secretion by an Androgen-Secreting Adrenal Adenoma in an Adult Female Patient

Endocrine Practice (2015)

Mohammed Ahmed Abdulraof Almahfouz Hindi Al‐Hindi Tarek A. Amin

Adrenal adenoma

10.1016/s1530-891x(20)42497-8

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Abstract #740: Hemosiderin Endocrinopathies and Cardiac Conduction Abnormalities in Patients With Hemoglobinopathies

Endocrine Practice (2015)

Mohammed Ahmed Abdulraof Almahfouz

Hemosiderin

10.1016/s1530-891x(20)42723-5

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In VivoInsulin Signaling in the Myocardium of Streptozotocin-Diabetic Rats: Opposite Effects of Diabetes on Insulin Stimulation of Glycogen Synthase and c-Fos¹

Endocrinology (1999)

Ping H. Wang Abdulraof Almahfouz Francesco Giorgino Karen C. McCowen Robert J. Smith

Diabetes induced by streptozotocin (STZ) in laboratory rats leads to impaired glucose metabolism in the heart and changes in myocardial contractile protein isoform expression and cardiac function. The purpose of this study was to investigate in vivo insulin signaling responses in the myocardium of STZ-diabetic rats. Insulin rapidly stimulated tyrosine phosphorylation of the insulin receptor, insulin receptor substrate-1 (IRS-1) and, to a lesser extent, IRS-2 in normal and diabetic myocardium. In diabetic rats, there was 2-fold higher insulin receptor content and insulin-stimulated receptor tyrosine phosphorylation in comparison with control rats. IRS-1 tyrosine phosphorylation also increased in STZ diabetes in spite of a decrease in IRS-1 content, resulting in a 4-fold higher ratio of phosphorylated to total IRS-1. This was associated with 2-fold higher IRS-1 precipitable phosphatidylinositide 3-kinase activity in diabetic animals. Insulin stimulation of glycogen synthase activity was significantly diminished in STZ diabetes, consistent with resistance to insulin in a step downstream from phosphatidylinositide 3-kinase activation. Under the same experimental conditions, there was a marked increase in insulin stimulation of myocardial c-fos messenger RNA content in diabetic animals in comparison with controls. These data demonstrate altered early steps in insulin signaling in STZ-diabetic rat myocardium. Consequent oppositely directed disturbances in growth regulatory and glucose regulatory responses to insulin may contribute to the development of myocardial functional abnormalities in this model of diabetes.

Insulin receptor substrate

IRS1

10.1210/endo.140.3.6595

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Citations (33)

Whole-Body Positron Emission Tomographic Scanning in Patients with Adrenal Cortical Carcinoma

Clinical Nuclear Medicine (2003)

Mohammed Ahmed Abdulaziz Al‐Sugair Abdullah Alarifi Abdulraof Almahfouz Saif S. Al-Sobhi

AHMED, MOHAMMED F.A.C.P.*; AL-SUGAIR, ABDULAZIZ M.D.†; ALARIFI, ABDULLAH F.R.C.P.*; ALMAHFOUZ, ABDULRAOF M.D.*; AL-SOBHI, SAIF F.R.C.S.‡ Author Information

Positron emission

10.1097/01.rlu.0000067512.53644.fb

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Citations (17)

Management and clinical outcomes of patients with homozygous familial hypercholesteremia in Saudi Arabia

Monaldi Archives for Chest Disease (2023)

Naji Kholaif Tahir Mohamed Ibrahim S. Alharbi Sumayah Aljenedil Hind AlHumaidan

We report the incidence, patient characteristic with clinical outcomes in patients with homozygous familial hypercholesterolemia (HoFH) in Saudi Arabia. This is a retrospective and prospective, single center study which included 37 patients 14 years and older enrolled and followed up between 2018-2021 for three years. 46% were females, 78% were offspring of consanguineous marriage. LDLR mutation was in 78% and LDL-C/LDLRAP in 3% of patients. Mean LDL-C at the first presentation was 14.2±3.7 mmol/L, average Dutch lipid score was 20.9±6.24. LDL apheresis was performed on 70% of patients. Most patients were on ezetimibe (92%), high-dose statins ( 84%) and PCSK9 inhibitors (32%). 48.6% had aortic stenosis, out of which 30% had severe aortic stenosis. Ten underwent aortic valve surgery (5 mechanical valve, 3 Ross procedure, 1 aortic valve repair, 1 bioprosthetic valve) and one had transcatheter aortic valve implantation (TAVI). Coronary artery bypass surgery (CABG) was performed on 32% and percutaneous intervention (PCI) on 11% of patients. HoFH patients have complex diseases with high morbidity and mortality, and benefit from a highly specialized multidisciplinary clinic to address their clinical needs. Although there are several therapeutic agents on the horizon, early diagnosis, and treatment of HoFH remain critical to optimize patient outcomes.

Ezetimibe

Single Center

10.4081/monaldi.2023.2503

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Citations (5)

Abstract #294 Euglycemic Diabetic Ketoacidosis in Type 2 Diabetes Post Whipple Procedure and Intraoperative External Beam Radiation Therapy Case Report

Endocrine Practice (2018)

Wael Almistehi Abdulraof Almahfouz

Diabetic ketoacidosis

External beam radiation

Ketoacidosis

10.1016/s1530-891x(20)47139-3

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Citations (1)