Alexander K. Schuster

University Medical Center of the Johannes Gutenberg University Mainz

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Norbert Pfeiffer

Johannes Gutenberg University Mainz

157

Philipp S. Wild

German Centre for Cardiovascular Research

Karl J. Lackner

University Medical Center of the Johannes Gutenberg University Mainz

Thomas Münzel

University Medical Center of the Johannes Gutenberg University Mainz

Manfred E. Beutel

Johannes Gutenberg University Mainz

Achim Fieß

University Medical Center of the Johannes Gutenberg University Mainz

Irene Schmidtmann

University Medical Center of the Johannes Gutenberg University Mainz

Michael S. Urschitz

University Medical Center of the Johannes Gutenberg University Mainz

Stefan Nickels

Johannes Gutenberg University Mainz

Andreas Schulz

Johannes Gutenberg University Mainz

Cooperative Institutions

Johannes Gutenberg University Mainz

282

University Medical Center of the Johannes Gutenberg University Mainz

262

Heidelberg University

Klinik und Poliklinik für Psychosomatische Medizin und Psychotherapie

University Hospital Heidelberg

Ophthalmology Clinic

University Medical Center

Klinik und Poliklinik für Augenheilkunde Universitätsklinikum Regensburg

University of Cologne

Charité - Universitätsmedizin Berlin

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Suizidologie: Abschiedsbriefe und ihre Themen

Der Nervenarzt (2006)

Brigitte Eisenwort Andrea Berzlanovich Marc Heinrich Alexander K. Schuster Monika Chocholous

Quarter (Canadian coin)

Family member

10.1007/s00115-006-2210-z

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Citations (17)

Central Corneal Thickness in Spectral-Domain OCT and Associations with Ocular and Systemic Parameters

Journal of Ophthalmology (2016)

Alexander K. Schuster Joachim E. Fischer Urs Vossmerbaeumer

Background. Optical coherence tomography (OCT) allows quantitative analysis of the anterior segment of the eye with a noncontact examination. The aim of this study is to analyze associations of central corneal thickness (CCT) as measured by OCT with ocular and systemic cardiovascular parameters. Methods. A cross-sectional study of 734 persons was performed in a working age population. Only healthy eyes were included. A comprehensive ophthalmological examination including refraction, noncontact tonometry, and imaging of the anterior segment by SD-OCT was performed. In parallel, a broad range of systemic cardiovascular parameters were measured. Associations were analyzed using a generalized estimating equations' model. Results. CCT measurements showed a significant association with corneal curvature and intraocular pressure: a thinner CCT was associated with a flatter cornea and with lower intraocular pressure (p < 0.001). Age was positively associated with CCT (p < 0.001); all other cardiovascular parameters were not associated. Conclusion. A thinner cornea is associated with a flatter surface and with lower intraocular pressure readings, while there are no independent associations with refraction and systemic cardiovascular parameters. Our findings highlight the value of SD-OCT CCT measurements as a standard tool in anterior segment analysis.

Refractive Surgery

10.1155/2016/2596956

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Citations (10)

Association of lipid-lowering drugs and antidiabetic drugs with age-related macular degeneration: a meta-analysis in Europeans

British Journal of Ophthalmology (2022)

Matthias M. Mauschitz Timo Verzijden Alexander K. Schuster Hisham Elbaz Norbert Pfeiffer

Background/aims To investigate the association of commonly used systemic medications with prevalent age-related macular degeneration (AMD) in the general population. Methods We included 38 694 adults from 14 population-based and hospital-based studies from the European Eye Epidemiology consortium. We examined associations between the use of systemic medications and any prevalent AMD as well as any late AMD using multivariable logistic regression modelling per study and pooled results using random effects meta-analysis. Results Between studies, mean age ranged from 61.5±7.1 to 82.6±3.8 years and prevalence ranged from 12.1% to 64.5% and from 0.5% to 35.5% for any and late AMD, respectively. In the meta-analysis of fully adjusted multivariable models, lipid-lowering drugs (LLD) and antidiabetic drugs were associated with lower prevalent any AMD (OR 0.85, 95% CI=0.79 to 0.91 and OR 0.78, 95% CI=0.66 to 0.91). We found no association with late AMD or with any other medication. Conclusion Our study indicates a potential beneficial effect of LLD and antidiabetic drug use on prevalence of AMD across multiple European cohorts. Our findings support the importance of metabolic processes in the multifactorial aetiology of AMD.

10.1136/bjo-2022-321985

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Citations (10)

Presurgical visualization of primary breast carcinoma with PET emission and transmission imaging.

PubMed (1995)

U. Pietrzyk Klemens Scheidhauer Anton Scharl Alexander K. Schuster H Schicha

The aim of this study was to investigate a technique that visualizes findings from PET images in a context useful for surgery.Simultaneously acquired PET emission and transmission scans were used. By applying a multipurpose imaging, registration and rendering tool (MPM), displays of orthogonal and volume-rendered views or any combination thereof were obtained. The PET emission and transmission scans were acquired under routine conditions. The final user-customized display (with a combination of orthogonal cuts and rendered views) was processed in 10 min or less on commercially available hardware. Distinct features of the body shape were clearly visible on the volume-rendered transmission views. Hot spots, e.g., in primary breast cancer, from the emission scans could be easily assessed in their localization relative to the body outline.Rendering of the main signatures in a single comprehensive display makes this method potentially valuable for simple presurgical workup and therapeutic management of breast cancer.

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Citations (20)

Refraction Dependency Of Reference Values For Macular Dimensions As Determined By Spectral-domain Oct: A Normative Database For The 3D-OCT 2000

Investigative Ophthalmology & Visual Science (2012)

Urs Vossmerbaeumer Alexander K. Schuster Joachim E. Fischer

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Do biometric parameters improve the quality of optic nerve head measurements with spectral domain optical coherence tomography?

BMC Ophthalmology (2022)

Eva Elksne Julia V. Stingl Alexander K. Schuster Felix Mathias Wagner Esther M. Hoffmann

Spectral domain optical coherence tomography (SD-OCT) is a widely applied non-invasive technique for evaluating optic nerve head parameters. The aim of this study was to evaluate the impact of biometric parameters such as the spherical equivalent (SE) and the anterior corneal curvature (ACC) on the peripapillary retinal nerve fiber layer (pRNFL), Bruch's membrane opening (BMO), and the minimum rim width (MRW) measurements performed by spectral domain optical coherence tomography (SD-OCT) in glaucomatous and healthy eyes.In this cross-sectional, case-control prospective pilot study, the glaucoma group consisted of 50 patients with previously diagnosed and treated glaucoma and one healthy group of 50 subjects. Two consecutive examinations of pRNFL, BMO, and MRW with SD-OCT for every patient were performed without ACC and objective refraction (imaging 1) and with them (imaging 2).The interclass correlation coefficient (ICC) reflected high agreement between imaging 1 and imaging 2 in both groups. The ICC in the glaucoma and healthy groups for pRNFL (0.99 vs. 0.98), BMO (0.95 vs. 0.97), and MRW (1.0 vs. 1.0) was comparable.Our preliminary data from a small number of eyes showed that the measurements of pRNFL, MRW, and BMO reflected high agreement between both imaging techniques with ACC and objective refraction and without these parameters in subjects with a refractive error up to ± 6.0 diopters. Further studies with participants with higher refractive error are necessary to evaluate the impact of biometric parameters such as SE and ACC on measurements with SD-OCT.

10.1186/s12886-022-02281-6

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[Implementation of a digital semester for ophthalmology during the COVID-19 pandemic]./ Umsetzung eines digitalen Semesters Augenheilkunde während der COVID-19-Pandemie.

Der Ophthalmologe (2021)

Andreas Müller Felix Mathias Wagner Juliane Matlach Marion Zimmermann Heike Troeber

Presentation (obstetrics)

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Pandemic

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Association of Birth Weight with Central and Peripheral Corneal Thickness in Adulthood—Results from the Population-Based German Gutenberg Health Study

Children (2021)

Achim Fieß Michael S. Urschitz Susanne Marx‐Groß Markus Nagler Philipp S. Wild

Purpose: Low birth weight (BW) is associated with altered ocular geometry such as a steeper corneal shape in adulthood. However, it is unclear whether low birth weight affects corneal thickness development in the center or periphery in adulthood which may contribute to ocular disease. The purpose of this study was to investigate corneal thickness in former low birth weight individuals in adulthood. Methods: The German Gutenberg Health Study is a prospective, population-based study in which every participant (age range 40-80 years) was measured with Scheimpflug imaging (Pentacam HR, Oculus Optikgeräte GmbH, Wetzlar, Germany). BW was collected by self-reports. The relationship between birth weight and corneal thickness at different locations were assessed. Linear regression models were carried out including uni- and multivariable analyses with adjustment for age, sex, mean corneal radius, and white-to-white distance. Main outcome measures were corneal thickness at the apex, at the pupil center, and at the corneal periphery. Results: Overall, 5657 participants were successfully measured (3019 females, aged 56.0 ± 10.3 years). In multivariable analyses a lower BW was associated with a thinner corneal thickness at the apex (B = 1.71 µm/500 g, p < 0.001) and at the pupil (B = 1.69 µm/500 g, p < 0.001). These effects diminished towards the corneal periphery resulting in no differences in the perilimbal regions. Conclusion: The present study provides evidence that lower birth weight goes along with corneal thickness alterations even into adult ages of 40 to 80 years. Thinner measurements of the cornea were particularly found in the corneal center and diminished in the periphery. This indicates that there may be fetal origins affecting corneal thickness development particularly in the corneal center.

Scheimpflug principle

10.3390/children8111006

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Citations (8)

L'abbandono del dualismo eteronormativo della famiglia

Alexander K. Schuster

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Loss to follow-up in the employee sample of the Gutenberg Health Study between baseline and 5-year follow-up

Safety and Health at Work (2022)

Claudia Drossard Andreas Schulz Sylvia Jankowiak Thomas Münzel Alexander K. Schuster

Baseline (sea)

Sample (material)

10.1016/j.shaw.2021.12.1138

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