Isabel Guillen-Guillen

Salk Institute for Biological Studies

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Estrella Núñez‐Delicado

Universidad Católica San Antonio de Murcia

José Antonio Gabaldón

Universidad Católica San Antonio de Murcia

Ling Huang

Salk Institute for Biological Studies

Tomoaki Hishida

Wakayama Medical University

Concepción Rodrı́guez Esteban

Altos Labs

Pradeep Reddy

Altos Labs

Paloma Martínez‐Redondo

Salk Institute for Biological Studies

Juan Carlos Izpisúa Belmonte

Altos Labs

Kensaku Shojima

Hyogo Medical University

Reyna Hernández‐Benítez

Salk Institute for Biological Studies

Cooperative Institutions

Salk Institute for Biological Studies

Universidad Católica San Antonio de Murcia

Universidad de Murcia

Altos Labs

Plant Gene Expression Center

University of California, San Diego

Clínica Rementería

Centro de Investigación Biomédica en Red

Universitat de Barcelona

Chinese Academy of Sciences

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Detection of sulphathiazole in honey samples using a lateral flow immunoassay

Food Chemistry (2011)

Isabel Guillen-Guillen José Antonio Gabaldón Estrella Núñez‐Delicado Rosa Puchades Ángel Maquieira

10.1016/j.foodchem.2011.04.080

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Citations (27)

In vivo partial cellular reprogramming enhances liver plasticity and regeneration

Cell Reports (2022)

Tomoaki Hishida Mako Yamamoto Yuriko Hishida-Nozaki Changwei Shao Ling Huang

Mammals have limited regenerative capacity, whereas some vertebrates, like fish and salamanders, are able to regenerate their organs efficiently. The regeneration in these species depends on cell dedifferentiation followed by proliferation. We generate a mouse model that enables the inducible expression of the four Yamanaka factors (Oct-3/4, Sox2, Klf4, and c-Myc, or 4F) specifically in hepatocytes. Transient in vivo 4F expression induces partial reprogramming of adult hepatocytes to a progenitor state and concomitantly increases cell proliferation. This is indicated by reduced expression of differentiated hepatic-lineage markers, an increase in markers of proliferation and chromatin modifiers, global changes in DNA accessibility, and an acquisition of liver stem and progenitor cell markers. Functionally, short-term expression of 4F enhances liver regenerative capacity through topoisomerase2-mediated partial reprogramming. Our results reveal that liver-specific 4F expression in vivo induces cellular plasticity and counteracts liver failure, suggesting that partial reprogramming may represent an avenue for enhancing tissue regeneration.

Reprogramming

Liver Regeneration

KLF4

Progenitor

10.1016/j.celrep.2022.110730

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Citations (63)

αKLOTHO and sTGFβR2 treatment counteract the osteoarthritic phenotype developed in a rat model

Protein & Cell (2020)

Paloma Martínez‐Redondo Isabel Guillen-Guillen Noah Davidsohn Chao Wang Javier Prieto

Klotho

Human genetics

Developmental Biology

10.1007/s13238-019-00685-7

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Citations (18)

Comparative study of the oral absorption of microencapsulated ferric saccharate and ferrous sulfate in humans

European Journal of Nutrition (2013)

Carlos Contreras María Dolores Barnuevo Isabel Guillen-Guillen A. Luque Elisabet Lázaro

Transferrin saturation

Crossover study

Ingredient

Iron sulfate

Organoleptic

Food fortification

Fortified Food

10.1007/s00394-013-0565-z

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Citations (11)

Simultaneous Determination of Nine Sulphonamides by LC-MS for Routine Control of Raw Honey Samples

Food Analytical Methods (2016)

Isabel Guillen-Guillen Lucía Guardiola Luís Almela Estrella Núñez‐Delicado José Antonio Gabaldón

10.1007/s12161-016-0698-9

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Citations (15)

Fluorimetric determination of sulphathiazole in honey by means the formation of CDs inclusion complexes

Carbohydrate Polymers (2013)

Carmen Lucas-Abellán Isabel Guillen-Guillen María Teresa Mercader‐Ros Ana Serrano‐Martínez Estrella Núñez‐Delicado

Stoichiometry

10.1016/j.carbpol.2013.11.032

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Citations (7)

Detection and quantification of meat species by qPCR in heat-processed food containing highly fragmented DNA

Food Chemistry (2012)

María López-Andreo Miriam Aldeguer Isabel Guillen-Guillen José Antonio Gabaldón Antonio Puyet

10.1016/j.foodchem.2012.02.111

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Citations (50)

Efecto del consumo de quinua (Chenopodium quinoa) como coadyuvante en la intervención nutricional en sujetos prediabéticos.

Nutrición Hospitalaria (2017)

María Salud Abellán-Ruiz María Dolores Espinosa Carlos García Santamaría Carlos Javier Contreras Fernández Miriam Aldeguer García

Introducción: La quinua es un pseudocereal que contiene hidratos de carbono de bajo índice glucémico, fibra alimentaria, proteínas de alto valor biológico, fitoesteroles y ácidos grasos n-3 y n-6 que ha suscitado interés en la intervención nutricional de la prediabetes. Este estudio aleatorizado (2:1), controlado con placebo y doble ciego evaluó los efectos de la quinua sobre el índice de masa corporal (IMC), hemoglobina glicada (HbA1c), glucemia basal (GB) y el grado de saciedad y plenitud en pacientes prediabéticos. Material y método: Se aleatorizaron (2:1) 30 pacientes en dos ramas a estudio: el producto Kuska Active (quinua procesada) y placebo (maltodextrina). El periodo de ingesta fue de 28 días. Antes de iniciar el tratamiento y a los 28 días se determinó el IMC, HbA1c y la GB. La sensación de saciedad y plenitud se evaluó mediante escala visual analógica (EVA). Para demostrar la eficacia de la quinua procesada Kuska Active sobre las variables a estudio se realizó ANOVA para medidas repetidas con dos factores a estudio (factor intrasujeto: tiempo y factor intersujeto: producto consumido). Resultados: Finalizaron un total de 29 pacientes (placebo, n=10; quinua, n= 19). Se detectó en el grupo quinua procesada una disminución significativa en los valores de IMC (p<0,05), HbA1c (p<0,001) y un aumento en la sensación de saciedad y plenitud (p<0,001). No se encontraron diferencias significativas en los niveles de GB desde el momento basal hasta el periodo post-ingesta. Conclusiones: Los resultados muestran que la quinua procesada disminuye el IMC, los niveles de HbA1c, mantiene los niveles de GB y aumenta la sensación de saciedad y plenitud en pacientes prediabéticos.

10.20960/nh.843

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Citations (17)

In vivo partial reprogramming of myofibers promotes muscle regeneration by remodeling the stem cell niche

Nature Communications (2021)

Chao Wang Rubén Rabadán-Ros Paloma Martínez‐Redondo Zaijun Ma Lei Shi

Short-term, systemic expression of the Yamanaka reprogramming factors (Oct-3/4, Sox2, Klf4 and c-Myc [OSKM]) has been shown to rejuvenate aging cells and promote tissue regeneration in vivo. However, the mechanisms by which OSKM promotes tissue regeneration are unknown. In this work, we focus on a specific tissue and demonstrate that local expression of OSKM, specifically in myofibers, induces the activation of muscle stem cells or satellite cells (SCs), which accelerates muscle regeneration in young mice. In contrast, expressing OSKM directly in SCs does not improve muscle regeneration. Mechanistically, expressing OSKM in myofibers regulates the expression of genes important for the SC microenvironment, including upregulation of p21, which in turn downregulates Wnt4. This is critical because Wnt4 is secreted by myofibers to maintain SC quiescence. Thus, short-term induction of the Yamanaka factors in myofibers may promote tissue regeneration by modifying the stem cell niche.

Reprogramming

Stem cell niche

10.1038/s41467-021-23353-z

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Citations (81)

Head-space gas chromatography coupled to mass spectrometry for the assessment of the contamination of mayonnaise by yeasts

Food Chemistry (2019)

Natalia Arroyo‐Manzanares Bohdana Markiv J.D. Hernández Ignacio López-Garcı́a Isabel Guillen-Guillen

10.1016/j.foodchem.2019.03.083

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Citations (11)