The global prevalence of myopia is increasing, with a significant proportion of affected young individuals, particularly in countries and cities with relatively developed education in the Asia-Pacific region. This trend highlights the need for effective interventions to address the rising prevalence of myopia in adolescents.The objective of this study was to evaluate the efficacy and safety of orthokeratology lenses in the management of adolescent myopia through a comprehensive meta-analysis.A comprehensive search was conducted in four databases to identify relevant clinical controlled trials. The analysis focused on studies with a 95% confidence interval (CI) for either relative risk or mean difference. The heterogeneity of the research results was assessed using the I2 statistic.A total of eight studies were included in the meta-analysis. The findings indicated that the use of orthokeratology lenses (OKL) in adolescents with myopia was associated with significant reductions in axial length (SMD: -0.25; 95% CI: -0.31, -0.19; I2 = 18.7%, P < .01), refractive errors (SMD: 3.22; 95% CI: 2.84, 3.61; I2 = 0.0%, P < .01), and adverse reactions (OR: 1.37; 95% CI: 0.71, 2.65; I2 = 5.8%, P > .05) compared to the control group.The results of this study suggest that orthokeratology lenses (OKL) may be effective in managing myopia in adolescents, as evidenced by reductions in axial length, refractive errors, and adverse reactions. However, future research should include large sample sizes, multicenter studies with low risk of bias, and exploring the underlying mechanisms through basic medical research.
Objective To investigate the effects of combined with antibiotic eye drops and non-steroidal anti-inflammatory drugs eye drops after cataract surgery,then further study its safety and effectiveness after phacoemulsification.Methods One hundred and eighty cataract patients without complications were divided into three groups randomly: A group: used tobramycin dexamethasone eye drops after phacoemulsification.B group: used tobramycin dexamethasone eye drops and pranoprofen eye drops after phacoemulsification.C group: used gatifloxacin eye drops and pranoprofen eye drops after phacoemulsification.Then measured intraocular pressure at 3 days,7days and 14 days after phacoemulsification.The results were showed by means plus or subtracting standard,the groups means was compared by one-way aonva,the deviation of between groups means was compared by Student-Newman-Keuls.The difference of P0.05 had statistical significance.Results The intraocular pressure was significantly elevated in A group and B group compared with C group(P0.01).The intraocular pressure was significantly reduced in B group compared with A group at 3 days,7days and 14 days after phacoemulsification(P0.05).Conclusion To combine with gatifloxacin eye drops and pranoprofen eye drops was safety and effectiveness.It may be used to treat cataract patients after phacoemulsification.
Objective. To investigate the prevalence of refractive errors among school children in Suining City, Sichuan Province, and to provide a scientific basis for prevention and control of myopia. Methods. This was a school-based cross-sectional study. Children aged 6-15 years were selected from kindergartens, primary schools, and middle schools in the urban setting of Suining City. The children underwent ocular examination including measurement of uncorrected visual acuity (UCVA), visual acuity when wearing glasses, and noncycloplegic autorefractometry. Results. Of the 1200 eligible students, 1138 children (94.8%), 553 of them girls (47.4%), participated. The mean age was 10.64±2.89 years. The prevalence of myopia, hyperopia, astigmatism, and emmetropia was 59.1% (95% confidence interval (CI): 57.6, 60.5), 5.0% (95% CI: 4.7, 6.1), 38.4% (95% CI: 55.5, 58.5), and 25% (95% CI: 23.7, 26.2), respectively. In univariate analysis, the prevalence of myopia was correlated with age, female gender, and learning stage. The prevalence of hyperopia and astigmatism was correlated with age and learning stage. The prevalence of mild myopia, moderate myopia, and high myopia in the 1138 students was 17.7%, 41.4%, and 3.3%, respectively. The prevalence of mild, moderate, and high myopia all increased with age and learning stage. The prevalence of myopia differed by gender. The mean spherical equivalents of the right and left eyes were −1.40±1.99 diopters (D) and −1.29±1.93D , respectively, and the median values were -0.75 D and -0.6 D, respectively. The mean spherical equivalent increased with age, learning stage, and female gender. Conclusions. The most common type of refractive error was myopia which was associated with higher age, female gender, and higher learning stage. This study provides new data and recommendations for myopia-control in school-aged children in Sichuan province.
Objective To discuss the short-term outcomes of open reduction and two-portal approach internal fixation of unstable scapular neck fractures with double reconstruction titanium plates.Methods Thirteen patients with unstable scapular neck fracture were operatively treated in our department from September 2005 to September 2010.They were 10 men and 3 women,aged from 19 to 52 years (average,35.3 years).According to Euler' classification,there were 3 anatomical neck fractures and 10 surgical neck fractures (7 cases of type A and 3 cases of type B).All patients were fixated with double titanium reconstruction plates of 3.5 mm and screws.The software Digimizer3.1.1.0 was used to measure the glenoid angulations and the glenopolar angles (GPA) on the anterior scapular X-ray films.Shoulder functions were assessed by the Constant-Murley score and Herscovici score at the last follow-up.Results The 13 patients were followed up from 6 to 37 months (average,16.2 months).Anatomic reduction was achieved in 11 cases and almost anatomic reduction in 2.All incisions healed at one stage 7 to 9 days after surgery.The preoperative GA and GPA improved from 55.1° and 17.1° respectively to 27.1° and 36.2° post-operation.Clinical union of the fractures was achieved in a period from 6 to 12 weeks (average,8 weeks).At the last follow-up,the average Constant-Murley score was 79.6 points (from 54 to 95 points),with 9 excellent,3good and one poor cases; the average Herscovici score was 14.7 points (from 12 to 16 points),with 8 excellent,2 good,2 fair and one poor cases.No injury to the suprascapular arteries and nerves,infection or haematoma formation occurred.Conclusion Open reduction and two-portal approach for internal fixation of unstable scapular neck fractures can lead to anatomic reduction,stable internal fixation and satisfactory short-term functional outcomes.
Key words:
Scapula; Fractures, bone; Fracture fixation, internal; Bone plates
This study assessed the knowledge, attitude, and practice (KAP) of non-ophthalmic medical staff towards myopia-related fundus lesions. This multicenter, cross-sectional study enrolled non-ophthalmic medical staff of Suining City between January and May 2023 using a self-designed questionnaire. A total of 505 (93.19%) valid questionnaires were included. Their mean KAP scores were 8.10 ± 2.32 (range: 0–12), 20.27 ± 2.68 (range: 0–24), and 17.77 ± 5.04 (range: 0–28), respectively. Structural equation modeling indicated that knowledge has a positive effect on attitude (β = 0.307, P < 0.001), and attitude has a positive effect on practice (β = 0.604, P < 0.001). Moreover, a higher degree of myopia exhibited a positive effect on knowledge (β = 0.510, P < 0.001). Nurses and other medical staff showed a negative effect on knowledge (β = − 0.706, P < 0.001) compared to doctors. Working in secondary and tertiary public hospitals, as well as private hospitals, demonstrated a negative effect on practice (β = − 1.963, P < 0.001) compared to those working in primary hospitals. Non-ophthalmic medical staff exhibited moderate knowledge, positive attitudes, and moderate practices toward myopia-related fundus lesions. The degree of myopia, doctors vs. other medical staff, and the hospital level influence the KAP of non-ophthalmic medical staff.
This study aimed to explore the role of the long non-coding RNA NOTCH1-associated lncRNA in T cell acute lymphoblastic leukemia (lncNALT) in the pathogenesis of hypertensive retinopathy (HR). LncNALT expression levels were determined using reverse transcription-quantitative polymerase chain reaction. The effects of lncNALT knockdown on the viability, proliferation, migration, and invasion of human retinal microvascular endothelial cells (RMECs) were determined via 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide, 5-ethynyl-2'-deoxyuridine staining, and Transwell assays. Protein expression levels were determined using western blotting. We found that lncNALT expression levels were increased in RMECs treated with hydrogen peroxide (H2O2), while the knockdown of lncNALT rescued the viability, proliferation, migration, and invasion of RMECs treated with H2O2. Moreover, lncNALT interacted with ELAV like RNA binding protein 1 to affect the phosphatase and tensin homolog (PTEN) expression. Knockdown of lncNALT enhanced the viability, proliferation, migration, and invasion of RMECs via the PTEN/phosphoinositide 3-kinase (PI3K)/serine-threonine kinase (AKT) pathway. Taken together, knockdown of lncNALT enhanced the viability, proliferation, migration, and invasion of RMECs via the PTEN/PI3K/AKT pathway, suggesting that lncNALT could be a potential therapeutic target for patients with HR.lncNALT interacts with HuR to increase the stability and expression levels of the PTENlncNALT regulates HR via the PTEN/PI3K/AKT pathwaylncNALT may be a potential diagnostic biomarker for HR.
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