Hitoshi Oikawa

Iwate Medical University

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i-10 index

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Clinical significance of hepaplastintest in hepatitis and liver cirrhosis

Blood & Vessel (1976)

I. Kaito Shunichi Sato Takashi Ishii Akio Yamashina Susumu MOTOYAMA

Hepaplastintest (HPT) was comparatively evaluated in 140 cases with liver diseases (9 fulminant hepatitis, 34 acute hepatitis, 50 chronic hepatitis and 47 liver cirrhosis), and in 31 normal subjects. The following results were obtained.1) The normal range of the activities of hepaplastintest was 80.3-134.3%.2) The activities of hepaplastintest showed a decrease in patients with hepatitis and liver cirrhosis as compared to normal subjects, especially in fulminant hepatitis and in liver cirrhosis with coma.3) In patients with hepatitis and liver cirrhosis, there was a correlation between the activity of hepaplastintest and the severity of the disease.4) An increase in PIVKA-inhibitor (more than 0.5), as an index of the complication of disseminated intravascular coagulation (DIC), was found in 1/3 of the the cases with fulminant hepatitis.Therefore, it is thought that the determination of hepaplastintest in hepatitis and liver cirrhosis is useful to determine the diagnosis and the prognosis of the diseases. Also involvement of DIC was suggested in fulminant hepatitis from the aspect of PIVKA-inhibitor.

Fulminant hepatitis

Fulminant

Liver disease

10.2491/jjsth1970.7.735

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Correlation between blood biomarkers and depression and anxiety scales in apparently healthy individuals

Kazumasa Isobe Tomoko Ishizu Hitoshi Oikawa Takashi Kamimaki Ishijima Michikuni

3 Summary Aim The purpose of this study was to assess the correlations between blood biomarkers and depression and anxiety scores in apparently healthy individuals. Methods The Beck Depression Inventory (BDI) and State-Trait Anxiety Inventories (STAI) 1 and 2 were administered to a total of 120 research participants. A blood sample was also obtained from each participant for measurements of biomarkers (serotonin, brain-derived neurotrophic factor (BDNF), high- sensitivity C-reactive protein (hsCRP), zinc, and folic acid). The Pearson moment correlation was used to determine correlations among the quantitative variables. Results A significant linear correlation between the BDI and STAI scores was found in all participants. An inverse linear correlation between the BDI score and folic acid was found in all partic- ipants (Pearson r = -0.206; P < .05). The STAI 2 score and folic acid were also inversely correlated (Pearson r = -0.292; P < .01), as were the STAI 1 score and BDNF (Pearson r = -0.234; P < .05). Conclusion Folic acid levels and BDNF levels may be useful for evaluating mental health status in apparently healthy individuals.

Depression

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