The newly developed IR nonlinear optical (NLO) material BaGa4Se7(BGSe) has aroused intense research interest owing to its excellent overall properties and outstanding IR laser output performance. In this paper, the growth of high-quality large-size BGSe was investigated. To overcome the difficulty of realizing the large-scale complete reaction among the highly active metal Ba, the liquid metal Ga, and the nonmetal with high vapor pressure Se, a two temperature-zone synthetic technique was developed, and over 300 g BGSe polycrystalline raw material with high purity was synthesized at one time. To avoid the crystal cracking and increase the usage for preparing NLO device, a crystal seed with appropriate orientation was selected for vertical Bridgman technique and high-quality crystals with dimensions up to Φ40 mm × 150 mm were grown successfully. The BGSe crystals exhibit high transmittance over a wide transparent range and the absorption coefficient was estimated around 0.04 cm–1 in the range of 1–13 μm. Moreover, via the two zone thermal annealing under the atmosphere of BGSe powder vapor, the transmittance of BGSe has been significantly improved.
Abstract Immune thrombocytopenia (ITP) is the most common autoimmune disorder characterized by decreased platelet counts and impaired platelet production. Eltrombopag has been demonstrated to be safe and effective for children with ITP. It is reported eltrombopag can achieve a sustained response off treatment. However, data on its overall efficacy and safety profile are scarce in children. This study aimed to investigate the long-term efficacy of eltrombopag in children with ITP. Treatment overall response (OR), complete response (CR), response (R), durable response (DR), no response (NR), treatment free remission (TFR), and relapse rate, were assessed in 103 children with ITP during eltrombopag therapy. The OR rate, CR rate, R rate, DR rate, NR rate, TFR, and relapse rate were 67.0%, 55.3%, 11.7%, 56.3%, 33.0%, 60%, 36.2%, respectively. Importantly, we discovered that newly diagnosed ITP patients showed a higher DR rate, TFR rate and lower relapse rate compared to persistent and chronic ITP patients. Furthermore, the CR rate, DR rate, and TFR rate of 5 patients under six months were 100%. None of them suffered relapse. The most common adverse event (AEs) was hepatotoxicity (7.77%). Our study highlighted the critical role of eltrombopag as the second-line treatment in children with ITP who were intolerant to first-line therapy.
Abstract Self‐healing binder is a prospective and efficient strategy to alleviate volume expansion of silicon (Si) anodes. However, excellent mechanical strength and healing ability tend to be mutually exclusive, due to enhanced tensile stress limit by twining polymer chains, while inhibiting polymer diffusion rate and inducing healing failure by blocked chains. Herein, inspired by the planning course of boat and paddles, a novel self‐healing binder (PVA‐4FBA‐PEI) is designed and synthesized with mobile parallel structure and twining‐blocked characteristics. The boat‐like intermediate (4‐formylphenyl) boronic acid (4FBA) blocks entanglement of poly(vinyl alcohol) (PVA) and poly(ethyleneimine) (PEI) chains, where two parallel chains as paddles can simultaneously form to ensure rapid diffusion of chains during bond breakage. Remarkably, it endows dynamic synergistic covalent bonds via C═N and B─O─C junctions within 4FBA, providing the binder with an ultrafast self‐healing time of merely 2 min. Moreover, the binder integrates superior plasticity and flexibility of each chain, showing a high tensile strength (14.4 MPa) and stretchability (1163%) among state‐of‐the‐art polymer binders, thus significantly improving structural integrity and electrochemical stability of Si anode during cycling. This work proposes a dynamic reversible structure via figurative molecular coordination, affording a rational viewpoint on synergetic functionalities of polymer binders for Si anodes.
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
Objective: To explore the correlations between RBCs indexes and the basic coagulation parameters, and provide data for further studies on high altitude-induced thrombotic disease.Methods: A total of eligible 433 volunteers were divided into different groups according to HGB concentration and HCT, respectively. PT, APTT, TT and Fbg were measured by clotting assays. HGB content, HCT and PLT count were assessed by automated hematology analyzer.Results: APTT and PT were significantly higher in group 4 (high HGB or HCT groups) (p < 0.05 for all comparison) and PLT count was significantly lower in group 4 than in other groups (p < 0.01 for all comparison). APTT and PT showed negative correlations with HGB concentration (r = −0.168 and −0.165 resp.; both p < 0.01), whereas positive correlations were found between APTT and HCT, PT and HCT (r = 0.225 and 0.258, resp.; both p < 0.01). PLT, TT and Fbg showed no correlation with HGB and HCT.Conclusions: HGB and HCT may not correlate with basic coagulation parameters in high altitude population, their predictive value for high altitude-induced thrombotic disease may relatively independent and this remain to be determined in further studies.
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