Pan Jia

National Institute for Viral Disease Control and Prevention

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Liqun Yu

Tongji University

Peiyu Jiang

Shaanxi Normal University

Yang Renguo

Wanjun Long

Asmau Mukhtar Sahabi

Lanxiu Ni

Chinese Academy of Sciences

Dong Lin

Shanghai Jiao Tong University

Lijuan Xiong

Union Hospital

Jijuan Cao

Dalian Minzu University

Xiaobo Zhang

Children's Hospital of Fudan University

Cooperative Institutions

Chinese Academy of Sciences

University of Chinese Academy of Sciences

Chinese Academy of Medical Sciences & Peking Union Medical College

Aviation General Hospital

Huazhong University of Science and Technology

Capital Medical University

Dalian Institute of Chemical Physics

Sun Yat-sen University

National Institute for Viral Disease Control and Prevention

Center for Disease Control

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Clinical role of experimental transcatheter occlusion of atrial septal defect complicated with severe pulmonary hypertension

Yunnan yiyao (2009)

Pan Jia

Objective To evaluate the clinical value of closure of atrial septal defect (ASD) in the patients with severe pulmonary hypertension (SPH) by applying the domestic occlusion device experimentally. Methods 12 cases of ASD associated with SPH were selected to attend this trial.The domestic occlusion device was used.The trial was to observe whether systolic pulmonary artery pressure (PASP) and mean pulmonary artery pressure (PAMP) decreased and whether oxygen saturation of blood changed. Results In 12 cases with SPH before occlusion,PASP was 10.9～ 19.3 (12.7±5.27) kPa,PAMP was 7.0～13.1 (9.4±2.6) kPa. In 4 cases,oxygen saturation of blood was less than 90%. In 30～60 minutes after pursuing to try to occlude ASD,PASP of 9 cases dropped to 5.8～13.4 (7.4±3.8) mmHg,their PAMP dropped to 2.4～8.1 (4.3±2.9) kPa,then occluded permanently for them. But in another 3 cases,pulmonary pressure and oxygen saturation of blood did not change significantly,they were not fit for closure. Conclusion The trial on closure of ASD in those patients with SPH,is a kind of safe and effective method,which differentiates whether pulmonary hypertension is obstructive or not. On selection of cases in pursuing occlusion of ASD in the patients with SPH,the trial has comparatively important clinical value.

Oxygen Saturation

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Diagnostic value of tuberculin test and anti-lipoarabinomannan IgG in tuberculous children

Journal of Bengbu Medicinae College (2001)

Pan Jia

Objective:To explore diagnostic value of purified protein derivative(PPD) test and detection of anti lipoarabinomannan IgG(anti LAM IgG) in tuberculous children.Methods:PPD test and anti LAM IgG detection were used in 66 tuberculous children and 30 non tuberculous children.Results:The positive rate of PPD tests in tuberculous was 59.1% and that of anti LAM IgG was 69.7%.The difference between these 2 methods were not significant( P 0.05),the positive rate(79.5%) of PPD in less severe cases was much higher than that(18.2%) in severe cases( P 0.005).The positive rate(70.5%) of anti LAM IgG in severe tuberculosis was similar to that(68.2%) of less severe tuberculosis( P 0.05).The false positive rate(36.7%) of PPD was much higher than that(3.3%) of anti LAM IgG( P 0.01) in patients without tuberculosis.Conclusions:Diagnostic value of PPD test in less severe tuberculosis is better than that of severe tuberculosis,diagnostic value of anti LAM IgG is better than that of PPD test in severe tuberculosis and the false positive rate is low in patients without tuberculosis.

Lipoarabinomannan

Purified protein derivative

Tuberculosis diagnosis

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Clinical Study on Selective Decontamination of the Digestive Tract for Prevention of Ventilator-associated Pneumonia

Zhejiang Journal of Integrated Traditional Chinese and Western Medicine (2010)

Pan Jia

Objective:To investigate the clinical effects of selective decontamination of the digestive tract(SDD) combined with posture intervention for prevention of ventilator-associated pneumonia(VAP). Methods:A total of 75 patients with artificial airways during mechanical ventilation were randomly allocated into the trial group(n=39) and control group(n=36).The control group received no preventive measures but routine treatment and patients in the trial group lay in a semireclining position at an angle of 30°-45° and were administered with polymyxin E 100 mg,tobramycin 80 mg and amphotericin B 500 mg by using the nasogastric tube,and on the basis of the above mentioned treatment,the nasopharynx was smeared with those three kinds of antibiotic ointments,once every six hours. Results:Forty-two of the 75 patients developed VAP and the cumulative incidence of VAP was 56.0%.The incidence and cumulative incidence of VAP were respectively 5.1% and 35.9% in the trial group and those were respectively 33.3% and 77.8% in the control group within 5 days after mechanical ventilation.Both the incidence and cumulative incidence of VAP were lower in the trial group than those in the control group(P0.05 or P0.01).The number of days for mechanical ventilation,the length of ICU stay,and the ICU hospitalization expense were respectively18.5±3.1 days,34.1±5.9 days and 45,634 ± 465 Yuan in the trial group,significantly lower than the respective 27.9±4.0 days,43.8±6.4 days and 68,793 ± 762 Yuan in the control group(P0.05). Conclusion:SDD in combination with posture intervention can help to reduce the incidence of VAP,and susquently resulting in reduction of the number of days for mechanical ventilation and the ICU hospitalization expense during ICU stay for patients receiving mechanical ventilation.

Ventilator-associated Pneumonia

Cumulative incidence

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Comparative Study on Colloidal Gold-labeled Method and ELISA of Testing Five Serological Markers of HBV

Journal of Clinical Transfusion and Laboratory Medicine (2012)

Pan Jia

Objective To investigate the sensitivity and specificity of testing HBsAg,HBsAb,HBeAg,HBeAb and HBcAb with colloidal gold-labeled method.Methods 256 serological cases were tested with both colloidal gold-labeled method and ELISA.The results of two methods were analyzed.Results All five negative results samples by ELISA were the same with colloidal gold-labeled method,but for the results HBsAg,HBeAb,HBcAb are positive;HBsAb,HBeAg are negative and HBsAg,HBeAg,HBcAb are positive;HBeAb,HBsAb are negative by ELISA,some were changed by colloidal gold-labeled method.The chi-aquare test(χ2) showed that the result differences of HBsAb and HBeAg were not statistically significant with two methods(P0.05).But χ2 test showed the differences were significant on HBsAg,HBeAb and HBcAb with two methods.The weak positive results by ELISA always were negative by colloidal gold-labeled method,but no negative results by ELISA were found positive tested by colloidal gold-labeled method.Conclusions The specificity of testing five serological markers of HBV has no difference between two methods,but ELISA is more sensitive than colloidal gold-labeled method.

HBeAg

Gold standard (test)

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The Correlation Between Bacterial Vaginosis, High-Risk Human Papillomavirus Infection, and Cervical Intraepithelial Neoplasia Progression

Research Square (Research Square) (2021)

Xiaolin Xu Yichan Zhang Liqun Yu Xingxian Shi Min Min

Abstract Persistent infection with high-risk human papillomavirus (HR-HPV) is an important reason for the progression of cervical intraepithelial neoplasia (CIN). Bacterial vaginosis (BV) is a genital infection that frequently presents in women infected with HPV, but the correlation between BV and HPV during CIN development is still elusive. In this study, we enrolled 624 participants and obtained 423 samples of vaginal secretions from them, including 193 HPV-negative samples and 230 HPV-positive samples. We used 16S rRNA sequencing to measure the vaginal microbiota diversity in women with or without BV and HPV co-infection and then calculated risk factors for CIN progression by logistic regression. We found that condom use (OR=3.480; 95% CI=1.069-11.325; P < .05) was a protective factor against CIN, whereas BV (OR=0.358; 95% CI=0.195-0.656; P < .05) and HR-HPV infection (OR= 0.016; 95% CI=0.004-0.072; P < .001) were risk factors for CIN. BV and HPV infection could trigger an increase in the diversity of vaginal microbiota and decrease Lactobacillus domination, which is conducive to CIN regression. The depletion of the carbohydrate metabolism pathway may induce Lactobacillus reduction. Treating BV in the clinical setting could block CIN development and L. iners may be a crucial species during this process.

Mycoplasma genitalium

10.21203/rs.3.rs-998392/v1

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A comparative study of olanzapine and risperidone in treating patients with treatment-resistant schizophrenia

Chin J Psychiatry (2010)

Zi-xiang Song Dehua Tu Pan Jia Zhan-kui Cai Tong-jun Yan

Objective To compare the efficacy and safety of olanzapine and risperidone in treatment of treatment-resistant schizophrenia.Methods A total of 68 patients with treatment-resistant schizophrenia were randomly assigned to olanzapine group and risperidone group, and received olanzapine or risperidone treatment for 12 weeks respectively.The efficacy and adverse events were assessed with the Positive and Negative Syndrome Scale (PANSS), Clinical Global Impression Scale (CGI) and Treatment Emergent Symptom Scale(TESS) at week 0 and 1,2,4,8,12.Results The PANSS scores in both groups decreased significantly after treatment (P 0.05).The response rate was higher in olanzapine group than risperidone group ( P 0.05), with olanzapine being associated with more weight gain, and risperidone with more akathisia, abnormal lactation and/or menostasia,hypermyotonia.Conclusion The results suggest olanzapine be of good efficacy and less side effects in the treatment of treatment-resistant schizophrenia in comparison with risperidone. Key words: Risperidone; Treatment outcome; Safety; Schizophrenia; Olanzapine

Akathisia

Clinical Global Impression

Dopamine antagonist

10.3760/cma.j.issn.1006-7884.2010.01.007

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Analysis of the Significance of Dynamic Electrocardiogram in Monitoring Arrhythmia in Patients with Coronary Heart Disease

Shuliyiyaoxue Zazhi (2019)

Pan Jia

Cardiac arrhythmia

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Plasma Protein S Deficiency and Ischemic Stroke

Journal of Zhejiang University(Medicine Edition) (2001)

Pan Jia

Objective: To investigate changes of plasma protein S in ischaemic stroke.Methods: Forty two patients with ischemic stroke and 40 healthy volunteers were enrolled in this trial.Plasma protein S activity was detected by clotting assay on the ACL 300 automantic coagulation laboratory;total and free PS were determined by enzyme linked immunosorbant assay(ELISA).Results: Among 42 patients, 7 with protein S activity dificiency were found while only 2 of them showed marked decrease in antigens of free protein S. Conclusion:Protein S deficiency may develop in ischemic stroke patients,however 70% of them do not have a current decrease of antigen of free PS.

Stroke

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Effect of long-term antiviral treatment with interferon combined with nucleoside analogues on HBsAg

Pan Jia Nan Jiang Yang Xingxiang Yang Renguo

Nucleoside analogue

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Contributors

Elsevier eBooks (2025)

Zoha Babaei Afrapoli Arafeh Bigdeli Jijuan Cao Yangyang Chang Siying Che

10.1016/b978-0-443-13356-5.09992-4

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