Patricia Carla Lopes

Universidade Estadual Paulista (Unesp)

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Guilherme Rodrigues Teodoro

Universidade Estadual Paulista (Unesp)

Gabriela de Morais Gouvêa Lima

Universidade Estadual Paulista (Unesp)

Cybelle Mori Hiraoka

Universidade de São Paulo

Gabriela de Fátima Santana-Melo

Universidade Estadual Paulista (Unesp)

Fernanda Lourenção Brighenti

Universidade Estadual Paulista (Unesp)

Daniel Freitas Alves Pereira

Universidade Estadual Paulista (Unesp)

Marina Bacelar Silva

Universidade Estadual Paulista (Unesp)

Cristiane Yumi Koga‐Ito

Universidade Estadual Paulista (Unesp)

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Universidade Estadual Paulista (Unesp)

Universidade de São Paulo

Universidade do Vale do Paraíba

Universidade de Taubaté

Fundação Faculdade de Odontologia

Centro Universitário de Araraquara

National Institute on Population Medical Genetics

Academic Center for Dentistry Amsterdam

University of Amsterdam

University of Padua

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Alternative therapies for denture stomatitis treatment: in vivo experimental model in rats

Brazilian Dental Science (2017)

Guilherme Rodrigues Teodoro Gabriela de Morais Gouvêa Lima Marina Bacelar Silva Patricia Carla Lopes Cybelle Mori Hiraoka

Background: Denture stomatitis (DS) is a multifactorial condition that commonly affects denture users and is mainly caused by Candida albicans. Due to the toxic effects of antifungal therapy, new therapies for DS are claimed. Objective: The aim of the study was to evaluate the efficacy of aqueous extract of Buchenavia tomentosa and sodium bicarbonate against C. albicans in a model of DS in rats. Material and Methods: An acrylic resin device simulating a denture base was fixed covering the palate of forty-eight male rats followed by candidiasis induction. Rats were divided into 4 groups (n=12): Control, sodium bicarbonate, B. tomentosa and nystatin (positive control). Each group was subdivided according to the period of treatment; 24 hours (n=6) and 48 hours (n=6). Animals were sacrificed and had their devices removed for C. albicans counts and SEM analysis. The palate mucosa was removed and processed for histopathologic analysis. Results: After 24 hours of treatment, both B. tomentosa and nystatin groups reduced significantly C. albicans counts when compared to control (nystatin x control, p<0.01; B. tomentosa x control, p=0.03). The results were confirmed by the histologic analysis. Conclusion: Both the aqueous extract of B. tomentosa and sodium bicarbonate was able to significantly decrease C. albicans counts in an experimental model of DS.

Nystatin

Sodium bicarbonate

10.14295/bds.2017.v20i1.1368

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