W. Poser

Universitätsmedizin Göttingen

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S. Poser

Centre National de la Recherche Scientifique

A. Hasselblatt

University of Göttingen

U. Panten

Technische Universität Braunschweig

Hannelore Ehrenreich

Max Planck Institute of Experimental Medicine

E. Rüther

University of Göttingen

B. Müller‐Oerlinghausen

Medizinische Hochschule Brandenburg Theodor Fontane

Barbara C. Wolf

Dade County Medical Examiner Department

Eckart Rüther

Ludwig-Maximilians-Universität München

Steven Poser

Albert Einstein College of Medicine

Henning Krampe

Humboldt-Universität zu Berlin

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University of Göttingen

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Klinik und Poliklinik für Psychiatrie und Psychotherapie

Universitätsmedizin Göttingen

Ludwig-Maximilians-Universität München

Heidelberg University

Max Planck Institute of Experimental Medicine

Universität Ulm

Max Planck Society

LMU Klinikum

Freie Universität Berlin

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Prognostic indicators in multiple sclerosis

Acta Neurologica Scandinavica (2009)

S. Poser W. Poser Gustav Schlaf W. Firnhaber Klaus Lauer

Abstract The influence of sex, age at onset, course of the disease and initial symptomatology on the mortality of patients with multiple sclerosis is analysed. A sample of 1926 patients was followed up prospectively over 4.9 years. Both, the mortality ratio (number of observed to expected deaths) and the excess death rate are calculated. Whereas the mortality ratio as a parameter of overall mortality is influenced by a variety of factors, such as age and sex; the excess death rate represents the number of extra deaths per 1000 exposed to risk in an indicated year and is, therefore, a parameter of the mortality which is attributed to MS. The excess death rate was comparable for the sexes, it was slightly higher for patients with a higher age at onset and it was clearly higher for the progressive course. Patients with initial diplopia and sensory signs and symptoms had the lowest excess death rate, whereas patients with pareses, cerebral and sphincter disturbances at onset showed the highest excess death rate.

Excess mortality

Standardized mortality ratio

10.1111/j.1600-0404.1986.tb03531.x

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Zur Kulturgeschichte der Suchtkrankheiten

Vandenhoeck & Ruprecht eBooks (2007)

W. Poser

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10.13109/9783666491191.42

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