Alessia Cerrato

University of Padua

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Christian Bacci

University of Padua

Matteo Cocco

University of Padua

Gastone Zanette

University of Padua

Eriberto Bressan

University of Padua

Annalisa Angelini

University of Padua

Chiara Castellani

Meyer Children's Hospital

Ludovica Pampaloni

University of Padua

Anna Chiara Frigo

University of Padua

Elisa Bardhi

University of Padua

Luca Sbricoli

University of Padua

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University of Padua

University of Milan

Azienda Ospedaliera di Padova

UCLouvain

Weatherford College

Instituto de Histología y Embriología de Mendoza

Consejo Nacional de Investigaciones Científicas y Técnicas

Istituto Nazionale Tumori IRCCS "Fondazione G. Pascale"

Icesi University

University of Verona

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The Follow-Up Necessity in Human Papilloma Virus-Positive vs. Human Papilloma Virus-Negative Oral Mucosal Lesions: A Retrospective Study

Journal of Clinical Medicine (2023)

Armina Rushiti Chiara Castellani Alessia Cerrato Marny Fedrigo Luca Sbricoli

Human papilloma virus (HPV) is known as the main cause of cervical cancer. Data also indicate its role in head–neck cancer, especially oropharyngeal cancer. The correlation between high-risk HPV and oral cancer is still controversial. HPV-related lesions of the oral cavity are frequent and, in most cases, benign. The primary aim of this study was to establish if there is a different follow-up necessity between HPV-positive compared to HPV-negative oral lesions. The secondary aim was to evaluate the recurrence of HPV-related lesions. All patients who underwent a surgical procedure of oral biopsy between 2018 and 2022, with ulterior histopathological examination and HPV typing, were examined. A total of 230 patients were included: 75 received traumatic fibroma as diagnosis, 131 HPV-related lesions, 9 proliferative verrucous leukoplakia, and 15 leukoplakia. The frequency and period of follow-up varied in relation to HPV positivity and diagnosis. This study confirms what has already been reported by other authors regarding the absence of recommendations of follow-up necessity in patients with oral mucosal lesions. However, the data demonstrate that there was a statistically significant difference in the sample analyzed regarding the follow-up of HPV-positive vs. HPV-negative patients. It also confirms the low recurrence frequency of HPV-related oral lesions.

10.3390/jcm13010058

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Bio-impedance analysis of mucosal tissues of the oral cavity: a comparison between healthy patients and patients affected by oral lichen planus

Frontiers in Physiology (2019)

Christian Bacci Matteo Cocco Alessia Cerrato Elisa Bardhi Ludovica Pampaloni

Event Abstract Back to Event Bio-impedance analysis of mucosal tissues of the oral cavity: a comparison between healthy patients and patients affected by oral lichen planus Christian Bacci1*, Matteo Cocco1, Alessia Cerrato1, Elisa Bardhi1, Ludovica Pampaloni1 and Gastone Zanette1 1 University of Padova, Department of Neurosciences - section of Clinical Dentistry, Italy Aim. Lichen Planus is a chronic inflammatory autoimmune disease that may affect the skin, the mucous membranes of the oral cavity and also other mucosae. The prevalence is estimated to be around 1–2% among population worldwide and oral manifestations may appear under various aspects, namely reticular, plaque-like, erosive, atrophic or bullous. The buccal mucosa, the tongue and the gingivae are the most commonly involved, but other areas may be affected too. Erosive OLP shows the highest risk of malignant transformation among the various subtypes. Biolelectrical Impedance analysis is a method used for an accurate evaluation of tissues composition. The bioelectrical impedance data are a combination of capacitive and resistive type elements which, as a result, provide reactance and resistance. Reactance (Xc) should be representative of the opposition of body tissues to the flow of electrical current or voltage and resistance (R) should be representative of the conduction of fluid of the direct or alternating current. According to resistance and reactance, a phase angle (PA, φ) is calculated. PA values may range from 90° to 0° and a correlation between PA values and body cell mass is demonstrated. For example, if a tissue would have been composed of cells membranes only, it would have higher resistance, lower capacitance and a PA value of 90°, whereas a tissue composed mainly by fluids would show lower resistance, higher capacitance a PA value of 0°. According to these evidences, the PA values of neoplastic tissue are expected be lower than those of normal tissue. The aim of the present study is to compare the values of bioimpedance analysis of healthy patients to the values of patients affected by OLP and, if possible, to establish some cut-off values, which could be related to an higher or lower risk of malignant transformation. Materials and Methods. Bioelectrical impedance analysis and PA measurements have been obtained using a special device, (Akern, Bia 101 Anniversary). The measurements were carried out by the same clinician. We evaluated 57 consecutive cases affected by reticular LPalready confirmed at the histological examination (case-group) and 60 heathy patients (control-group). The measurements have been performed in the buccal mucosae, the tongue, hard palate and upper anterior gingiva. Results. Reactance and resistance of hard plate and gum were generally higher in the case-group than in the control-group the results are statistically significant. The mean resistance of hard plate was 75,7 (±13,8) for the control-group and 80,6 (±16,7) for the case group (p 0,044) and the mean reactance was 14,5 (±5,5) for the control group and 17,0 (±6,3) for the case group (p 0,020). The mean resistance of gum was 59,0 (±13,8) in the control group and 78,6 (±30,5) in the case group (p <.0001) and the mean reactance was 13,6 (±5,7) in the control group and 19,6 (±11,8) in the case group (p <.0001). In the case group the mean phase angle of healthy mucosae and reticular lesions were higher than the phase angle of erosive lesions. The mean phase angle of mucosae with no lesions was 12,6 (±1.2), of reticular lesions was 12,4 (±1.7) and of erosive lesions was 11.1 (±0,6). There were no statistically significant differences between healthy mucosae and reticular lesions (p 0,79) but there were statistically significant differences between healthy mucosae than erosive lesions (p 0,005) and reticular lesions than erosive lesions (p 0,04). Discussion. These results provide evidence of the usefulness of bioimpedance assay for the characterization of healthy and clinically OLP affected mucosa. Bioimpedance is a valid aid in the early detection and clinical monitoring of the suspicious lesions which could lead to a potentially malignant evolution. References 1. M Tatullo, M Amantea, F Paduano, L Santacroce, S gentile, S sacco. Bioimpedance Detection of Oral Lichen Planus Used as Preneoplastic Model Cancer 2015;6(10):976-83 2. Kyle, U.G, Bosaeus, I.; De Lorenzo, A.D.; Deurenberg, P.; Elia, M.; Gómez, J.M.; Heitmann, B.L.; Kent-Smith, L.; Melchior, J.-C.; Pirlich, M. Bioelectrical impedance analysis—Part i: Review of principles and methods. Clin. Nutr. 2004, 23, 1226–1243. 3. De Lorenzo, A.; Andreoli, A.; Matthie, J.; Withers, P. Predicting body cell mass with bioimpedance by using theoretical methods: A technological review. J. Appl. Physiol. 1997, 82, 1542–1558. Keywords: Oral lichen planus (OLP), Bioimpedance analysis (BIA), Precancerous lesions, Oral Cancer (OC), oral mucosa Conference: 5th National and 1st International Symposium of Italian Society of Oral Pathology and Medicine., Ancona, Italy, 19 Oct - 20 Oct, 2018. Presentation Type: Poster Presentation Topic: Oral Diseases Citation: Bacci C, Cocco M, Cerrato A, Bardhi E, Pampaloni L and Zanette G (2019). Bio-impedance analysis of mucosal tissues of the oral cavity: a comparison between healthy patients and patients affected by oral lichen planus. Front. Physiol. Conference Abstract: 5th National and 1st International Symposium of Italian Society of Oral Pathology and Medicine.. doi: 10.3389/conf.fphys.2019.27.00048 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 01 Nov 2018; Published Online: 09 Dec 2019. * Correspondence: Dr. Christian Bacci, University of Padova, Department of Neurosciences - section of Clinical Dentistry, Padova, Veneto, 35122, Italy, christian.bacci@unipd.it Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Christian Bacci Matteo Cocco Alessia Cerrato Elisa Bardhi Ludovica Pampaloni Gastone Zanette Google Christian Bacci Matteo Cocco Alessia Cerrato Elisa Bardhi Ludovica Pampaloni Gastone Zanette Google Scholar Christian Bacci Matteo Cocco Alessia Cerrato Elisa Bardhi Ludovica Pampaloni Gastone Zanette PubMed Christian Bacci Matteo Cocco Alessia Cerrato Elisa Bardhi Ludovica Pampaloni Gastone Zanette Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.

Oral Lichen Planus

10.3389/conf.fphys.2019.27.00048

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Bio-electrical Impedance Analysis of Oral Cavity Mucosae in Patients With Lichen Planus and Healthy Controls

Research Square (Research Square) (2021)

Alessia Cerrato Matteo Cocco Gastone Zanette Anna Chiara Frigo Christian Bacci

Abstract OBJECTIVE Oral lichen planus (OLP) is a chronic inflammatory. Bio-electrical impedance analysis (BIA) is a method for assessing tissue composition. Based on a combination of reactance and resistance data, a phase angle (PA) is calculated. The PA may range in value from 90° to 0°, correlates with body cell mass. There is evidence suggesting that the PA of neoplastic tissue is lower than that of normal tissue. The aim of the present study was to compare the findings of BIA on the oral mucosae of patients with OLP and healthy controls. MATERIALS AND METHODS BIA measurements were obtained with a specific device and PA values were calculated, in a sample of 57 consecutive cases OLP and 60 healthy controls. Impedance measurements were taken for the buccal mucosae, tongue, hard palate and upper anterior gums. RESULTS The resistance, reactance and PA of the hard plate and gums were generally higher in the OLP group than in the control group, and the differences were statistically significant. The median PA of healthy and reticular lesions was higher than that of erosive lesions. CONCLUSIONS These results support the usefulness of BIA for the characterization of healthy oral mucosa and OLP lesions.

Oral Lichen Planus

Reticular connective tissue

Reactance

10.21203/rs.3.rs-254678/v1

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