Shaodong Jiang

Research Center for Eco-Environmental Sciences

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Hongyun Niu

Research Center for Eco-Environmental Sciences

Yaqi Cai

Jianghan University

Yali Shi

Research Center for Eco-Environmental Sciences

Qing Sun

Research Center for Eco-Environmental Sciences

Pengyuan Yang

Institute of Biophysics

Xiaoling Gu

Research Center for Eco-Environmental Sciences

Federico Rosei

Institut National de la Recherche Scientifique

Yajing Hao

Nanjing Agricultural University

Shuanshi Fan

South China University of Technology

Gongshin Qi

Sichuan Agricultural University

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Chinese Academy of Sciences

University of Chinese Academy of Sciences

Chinese Academy of Agricultural Sciences

Lanzhou Veterinary Research Institute

Lanzhou University

Peking University

The Faraday Institution

University of Electronic Science and Technology of China

University of Science and Technology of China

Gansu Provincial Center for Disease Control and Prevention

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Correction to “Thiol–Ene Click Chemistry: A General Strategy for Tuning the Properties of Vinylene-Linked Covalent Organic Frameworks”

ACS Applied Materials & Interfaces (2025)

Xiaoling Gu Hongyun Niu Qing Sun Shaodong Jiang Yali Shi

Ene reaction

Thiol

10.1021/acsami.5c02421

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3D landscape of Hepatitis B virus interactions with human chromatins

Cell Discovery (2020)

Bo Yang Boyuan Li Liyang Jia Yongpeng Jiang Xin Wang

Abstract Hepatitis B viral (HBV) DNAs, including covalently closed circular DNA (cccDNA) and integrated HBV DNA forms, are considered to be primary contributors to the development and progression of HBV-associated liver diseases. However, it remains largely unclear how HBV DNAs communicate with human chromatin. Here we employed a highly sensitive technology, 3C-high-throughput genome-wide translocation sequencing (3C-HTGTS), to globally identify HBV DNA–host DNA contacts in cellular models of HBV infection. HBV DNA does not randomly position in host genome but instead preferentially establishes contacts with the host DNA at active chromatin regions. HBV DNA–host DNA contacts are significantly enriched at H3K4me1-marked regions modified by KMT2C/D; this histone modification is also observed in the HBV cccDNA mini-chromosome and strongly influences HBV transcription. On the other hand, chromatin loop formed by integrated HBV DNA with host genomic DNA was found in transcriptionally active regions. Furthermore, HBV infection influences host gene expression accompanied with HBV DNA–host DNA contacts. Our study provides a 3D landscape of spatial organization of cccDNA and integrated HBV DNA within the human genome, which lays the foundation for a better understanding of the mechanisms how HBV involves in liver disease development and progression.

cccDNA

10.1038/s41421-020-00218-1

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Citations (26)

Thiol–Ene Click Chemistry: A General Strategy for Tuning the Properties of Vinylene-Linked Covalent Organic Frameworks

ACS Applied Materials & Interfaces (2025)

Xiaoling Gu Hongyun Niu Qing Sun Shaodong Jiang Yali Shi

Vinylene-linked Covalent Organic Frameworks (V-2D-COFs) are a class of promising porous organic materials that feature fully π-conjugated structures, high crystallinity, ultrahigh chemical stability, and extraordinary optoelectronic properties. However, the types of reactions and the availability of monomers for synthesizing

Ene reaction

Dynamic Covalent Chemistry

Covalent organic framework

10.1021/acsami.4c19765

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NDRG1 facilitates self-renewal of liver cancer stem cells by preventing EpCAM ubiquitination

British Journal of Cancer (2023)

Qian Cheng Shanglei Ning Lei Zhu Changlu Zhang Shaodong Jiang

10.1038/s41416-023-02278-y

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Influence of Foot-and-Mouth Disease Virus O/CHN/Mya98/33-P Strain Leader Protein on Viral Replication and Host Innate Immunity

Viral Immunology (2015)

Shaodong Jiang Xingwen Bai Pinghua Li Meng Zhang Huifang Bao

Foot-and-mouth disease virus (FMDV) O/CHN/Mya98/33-P strain was isolated from the esophageal-pharyngeal fluid sample of cattle, and was shown to cause persistent infection. Its leader protein contains 200 amino acids with one amino acid deletion, which is upstream and next to the second initiation codon compared with the majority of FMDV Mya98 strains. The FMDV genome includes two initiation codons that can produce two different leader proteins, Lab (from the first AUG) and Lb (from the second AUG). For convenience, the inter-AUG region was named as La. Previously, it was found that a recombinant virus with Lab of FMDV O/CHN/Mya98/33-P strain had higher proliferation efficiency, and better ability to inhibit the host innate immune response. Three full-length infectious cDNA clones—rHN33-Lb, rHN33-La, and rHNGSLX-Lb—containing the FMDV O/CHN/Mya98/33-P strain leader proteins Lb, La, or the FMDV O/GSLX/2010 strain leader protein Lb, respectively, were constructed based on an established infectious clone r-HN rescued from FMDV O/HN/CHN/93 strain. After infecting pig kidney primary cells, rHN33-La showed higher replication efficiency than r-HN, and rHN33-Lb displayed better ability to resist host innate immunity than rHNGSLX-Lb. These results demonstrated that the inter-AUG region of FMDV strain O/CHN/Mya98/33-P leader protein must be involved in increasing viral replication efficiency. Additionally, the Lb of FMDV O/CHN/Mya98/33-P must be involve in increasing its ability to inhibit host innate immune response, and the distinctive amino acids G56 and/or R118 of FMDV leader protein may play essential roles in it.

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Aphthovirus

10.1089/vim.2014.0150

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Establishment of an inducible cell line for Hepatitis B virus genotype C2 and its pharmacological responses to interferons

Pharmacological Research (2022)

Shaodong Jiang Xin Wang Kaili Chen Pengyuan Yang

cccDNA

10.1016/j.phrs.2022.106142

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Citations (1)