Myostatin is a member of the transforming growth factor beta (TGF-beta) superfamily that functions as a negative regulator of skeletal muscle development and growth. Myostatin blockade therefore offers a strategy for promoting muscle growth in livestock production without resorting to genetic manipulation. In this report, we examined the effect of myostatin inhibition by plasmid-mediated delivery of a mutant myostatin propeptide (MProD76A), a natural inhibitor of myostatin, on the growth performance of mice. A significant increase in skeletal muscle mass was observed after a single intramuscular injection of naked plasmid DNA encoding MProD76A into mice. Enhanced muscle growth occurred because of myofiber hypertrophy, but no cardiac muscle hypertrophy and organomegaly was observed in the mice after myostatin inhibition by plasmid-mediated MProD76A delivery. These results demonstrate a promising approach to enhancing muscle growth that warrants further investigation in domestic animals.

Myostatin

Myokine

Growth differentiation factor

C2C12

10.1155/2010/862591

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Additional file 9 of Expanded catalogue of metagenome-assembled genomes reveals resistome characteristics and athletic performance-associated microbes in horse

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Cunyuan Li Xiaoyue Li Rongjun Guo Wei Ni Kaiping Liu

Additional file 9: Table S7. Detailed description of the 36 core MAG. Core MAG were present in at least 90% samples.

Resistome

10.6084/m9.figshare.22610674

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Additional file 22 of Expanded catalogue of metagenome-assembled genomes reveals resistome characteristics and athletic performance-associated microbes in horse

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Cunyuan Li Xiaoyue Li Rongjun Guo Wei Ni Kaiping Liu

Additional file 22: Table S17. Abundance of antibiotic resistance genes in 242 samples.

Resistome

10.6084/m9.figshare.22610719

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Additional file 19 of Expanded catalogue of metagenome-assembled genomes reveals resistome characteristics and athletic performance-associated microbes in horse

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Cunyuan Li Xiaoyue Li Rongjun Guo Wei Ni Kaiping Liu

Additional file 19: Table S15. ARG encoded by horse intestinal MAG were identified into 25 resistance classes.

Resistome

10.6084/m9.figshare.22610707

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Additional file 17 of Expanded catalogue of metagenome-assembled genomes reveals resistome characteristics and athletic performance-associated microbes in horse

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Cunyuan Li Xiaoyue Li Rongjun Guo Wei Ni Kaiping Liu

Additional file 17: Table S13. Detailed information on the six active polysaccharide-degrading enzymes (GH, GT, PL, CE, CBM, and AA) among the proteins encoded by the 2272 genomes.

Resistome

10.6084/m9.figshare.22610698

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