АП

А П Юренев

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i-10 index

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Document Type

Co-Authors

I F Patrusheva

Institute of Experimental Cardiology

P B Dubov

Institute of Cardiology

E B Koniaeva

E V Erina

Institute of Cardiology

ЮН

Ю Н Беленков

Institute of Experimental Cardiology

Kh E Charyev

I D Novikov

Tel Aviv University

I K Shkhvatsabaia

Boris B. Salenko

Institute of Experimental Cardiology

O Kozdoba

Children's Health Ireland at Crumlin

Cooperative Institutions

Institute of Experimental Cardiology

National Medical Research Center of Cardiology

Institute of Cardiology

Ministry of Health of the Russian Federation

Russian Academy of Sciences

University of Southern California

Kumamoto University

Lomonosov Moscow State University

Cornell University

Medical Technologies (Czechia)

Author Statistics

Papers

Citation

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[The risk assessment for a fatal outcome in patients with stable angina based on the data from a long-term prospective observation (a comparison of the 5-year survival prognosis with the data at the 6th to 12th years of the observation)].

PubMed (1993)

Ю Н Беленков В. П. Лупанов A I Rubanovich I D Novikov G A Lediashova

A rule has been developed to predict coronary death in 377 patients with coronary heart disease and stable angina due to coronary stenotic atherosclerosis. Gravimetric values of various clinical signs, resting ECG changes, and bicycle ergometric testing have been obtained by a computer. A decisive rule has been also derived. According to the values of prognostic indices I1 and I2, groups of low, moderate, and high risks for fatal outcomes for 5 years have been identified and the patient's survival during a subsequent follow-up of 6 to 12 years has been assessed. The developed scheme of prognosis permits its use in practice.

Stable angina

Coronary disease

Unstable angina

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[Functional status of the hypertrophic left-ventricular myocardium in patients with hypertension].

PubMed (1989)

А П Юренев А П Савченко P B Dubov A. N. Samko S L Abramov

27 patients with IIB stage of essential hypertension (EH) and left ventricular hyperthropy (LVH), 14 of them with IHD, were studied. In all of them coronaro- and ventriculography was performed. In 14 cases atherosclerotic alterations of coronary arteries were present. Nobody had abnormal pump function or contractility of myocardium. End-systolic, end-diastolic and stroke volume indexes in EH patients with pronounced coronary atherosclerosis were significantly increased. The examined patients demonstrated significant alteration of the left ventricular myocardium relaxation function. The conclusion is drawn that on a certain stage LVH is of compensatory character and plays an important role in supporting adequate myocardial pump function.

Contractility

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[Results of a 5-year follow-up study and prognosis in patients with cardiac insufficiency].

PubMed (1989)

V A Krol Tatiana Nasonova N L Buianova I D Novikov А П Юренев

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[A painless decrease in the ST segment during the 24-hour ECG monitoring of hypertensive patients].

PubMed (1991)

E B Koniaeva Alexander Kosenko P B Dubov А П Юренев

The daily Holter ECG monitoring and echocardiography were conducted in 61 men aged on the average 50.5...1.2 years with a diagnosis of stage II essential hypertension. 55.7% of the patients manifested episodes of painless depression of the ST segment. Such parameters as the patients' age, duration and intensity of arterial hypertension, the painful syndrome pattern did not afford revealing persons at high risk for instability of the ST segment of the ECG. Only initial disorders of the repolarization phase of the ECG at rest, so-called ECG with the signs of left ventricle hypertrophy with "strain" were in this respect of prognostic importance. 2/3 of the patients with the left ventricle mass exceeding 200 g manifested episodes of "silent" depression of the ST segment, with those episodes being encountered more frequently in left ventricle hypertrophy with an asymmetry index greater than or equal to 1.5.

Depression

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Use of nebivolol in patients with mild and moderate hypertensive disease

Terapevticheskii arkhiv (2003)

Л В Жигунова Л В Жигунова Ye L Lakhova Elena Leonidovna Lakhova Alexei P. Yurenev

Aim. To evaluate the effectiveness and safety of the beta-adrenoblocker nebivolol in patients with mild and moderate essential hypertension. Material and methods. The trial enrolled 20 patients. 11 of them had mild and 9 moderate arterial hypertension (mean age 47.1 ± 9.52years, hypertension history 6.98 ± 2.75years). 2-5 days after discontinuation of hypotensive drugs the examination was made including blood count, ECG, echocardiography, 24-h AP monitoring. It was repeated on days 56-60 of nebivolol therapy. Arterial pressure and heart rate were measured at the start of the treatment and 1, 3, 5 and 8 weeks later. Results. Nebivolol treatment significantly reduced systolic arterial pressure in 30% and diastolic arterial pressure in 50% patients, heart rate decreased on the treatment day 7-10. On the treatment day 56-60 systolic and diastolic pressure lowered significantly in 53.3% and 66.7% patients, respectively. The analysis of changes in echocardiographic evidence found no significant shifts in volume and linear parameters. Nebivolol was well tolerated by 85% patients. Side effects included head ache, cardialgia, dizziness, weakness and nausea. Conclusion. Nebivolol (nebilet) is an effective hypotensive drug with mild side effects. Further studies on nebivolol effects on myocardial mass are needed.

Nebivolol

Discontinuation

Essential hypertension

Bisoprolol

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[Lesions of target organs in arterial hypertension].

PubMed (1986)

I K Shkhvatsabaia А П Юренев O Kozdoba

A total of 530 patients with a variety of hypertensive conditions, including 476 patients with labile and stable essential hypertension, 40 with hypertensive chronic diffuse glomerulonephritis and hypertensive chronic pyelonephritis, and 14 with vasorenal hypertension, were investigated. Structure and function of target organs (the heart and the kidneys) were assessed by means of echocardiography (530) and intravital morphologic studies of renal biopsy specimens (89). A heterogeneous nature of hypertrophic developments associated with essential hypertension was demonstrated, with adequate, inadequate, disproportionate and excessive hypertrophy identified, while no correlation could be found between the kind of hypertension and the degree and nature of hypertrophy. Renal morphologic changes were also shown to be heterogeneous in labile and stable arterial hypertension, and early involvement of the renal mechanism presenting as structural changes was found to be possible.

Essential hypertension

Compensatory hypertrophy

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Citations (4)

[Isometric loading in healthy persons under the control of hemodynamic parameters according to echocardiographic data].

PubMed (1975)

А П Юренев Louis E. Teichholz C Smithen

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[The effectiveness of psychorelaxation therapy in patients with hypertension].

PubMed (1988)

T A Aĭvazian В П Зайцев Boris B. Salenko А П Юренев I F Patrusheva

A study of 117 patients with labile essential hypertension before as well as 6 weeks and 12 months after psychorelaxation treatment (PRT), making use of autogenous training, biological feedback or respiratory relaxation training techniques (the main group), and the control patients, exposed to no psychological effects and those on the so-called psychological placebo, demonstrated a significantly greater fall of systolic and diastolic arterial blood pressure, total peripheral resistance and hypertensive response to emotional stress, as well as better psychological adaptation, quality of life and working capacity in the main-group patients, as compared to the controls, by the end of the study.

Placebo group

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Citations (2)

[Treatment of patients with arterial hypertension in Moscow].

PubMed (2001)

А П Юренев I F Patrusheva М. Д. Смирнова L M Kunnova

To analyze treatment for arterial hypertension in Moscow.1056 case histories of hypertensive patients referred to Moscow city cardiological hospital in 1999 were analysed. The analysis covered the following issues: frequency of use of antihypertensive drugs depending on the disease stage; adequacy of the doses; changes in the treatment due to the presence of hypertrophy of the left ventricular myocardium, cardiac failure, vascular complications, diabetes mellitus.Treatment of hypertension was not adequate in many patients. Often, inadequate decisions were made on the drugs doses, course regimens, monotherapy.Insufficiently effective treatment of arterial hypertension can result in aggravation of the disease and frequent complications.

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["Silent" myocardial ischemia and the activity of the sympathetic-adrenal system in hypertension patients].

PubMed (1991)

А П Юренев V De Quattro В Н Титов V P Guliaev А И Кузьмин

The aim of the study was to assess the sympathoadrenal activity at the time of silent ischemia event in hypertensive patients. In 15 hospitalized hypertensive patients having silent ischemia event during Holter ECG monitoring while walking, blood samples for catecholamines were taken at the time of silent ischemia event, pointed with alarm by the real time ECG "Q Med" monitor (USA). Control blood samples were taken under the same conditions without ST-segment depression. Plasma noradrenaline (NA) during silent ischemia was significantly higher than the control level without ischemia (458 +/- 71 ng/l vs 717 +/- 95 ng/l) (p less than 0.01). The changes in plasma NA correlated with left ventricular mass assessed by echocardiography (r = 0.70, p less than 0.01). The role of sympathoadrenal hyperactivity in the genesis of silent myocardial ischemia in patients with essential hypertension is discussed.

Sympathoadrenal system

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Citations (1)