Samir A. Ross

University of Mississippi

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Mahmoud A. ElSohly

University of Mississippi

Mohamed M. Radwan

University of Mississippi

Ikhlas A. Khan

University of Mississippi

Desmond Slade

MRIGlobal

Stephen J. Cutler

University of South Carolina

S. William Pelletier

Indiana University School of Medicine

Sabrin R. M. Ibrahim

Batterjee Medical College

Gamal A. Mohamed

King Faisal Specialist Hospital & Research Centre

S. Radhakrishnan

University of Mississippi

Frank R. Fronczek

Louisiana State University

Cooperative Institutions

University of Mississippi

212

Brigham and Women's Hospital

132

Thrombolysis in Myocardial Infarction Study Group

117

Assiut University

National Institutes of Health

University Hospital Brno

Al-Azhar University

Al-Farabi Kazakh National University

Harvard University

National Center for Advancing Translational Sciences

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Isolation and Biological Analysis of Aerial Parts of Salvia Aethiopis

Miriah B. White S. Radhakrishnan Charles L. Cantrell Samir A. Ross

Salvia

Isolation

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Citations (0)

Simultaneous Determination of 6-Shogaol and 6-Gingerol in Various Ginger (Zingiber officinale Roscoe) Extracts and Commercial Formulations Using a Green RP-HPTLC-Densitometry Method

Foods (2020)

Ahmed I. Foudah Faiyaz Shakeel Hasan S. Yusufoglu Samir A. Ross Prawez Alam

Various analytical methodologies have been reported for the determination of 6-shogaol (6-SHO) and 6-gingerol (6-GIN) in ginger extracts and commercial formulations. However, green analytical methods for the determination of 6-SHO and 6-GIN, either alone or in combination, have not yet been reported in literature. Hence, the present study was aimed to develop a rapid, simple, and cheaper green reversed phase high-performance thin-layer chromatography (RP-HPTLC) densitometry method for the simultaneous determination of 6-SHO and 6-GIN in the traditional and ultrasonication-assisted extracts of ginger rhizome, commercial ginger powder, commercial capsules, and commercial ginger teas. The simultaneous analysis of 6-SHO and 6-GIN was carried out via RP-18 silica gel 60 F254S HPTLC plates. The mixture of green solvents, i.e., ethanol:water (6.5:3.5 v/v) was utilized as a mobile phase for the simultaneous analysis of 6-SHO and 6-GIN. The analysis of 6-SHO and 6-GIN was performed at λmax = 200 nm for 6-SHO and 6-GIN. The densitograms of 6-SHO and 6-GIN from traditional and ultrasonication-assisted extracts of ginger rhizome, commercial ginger powder, commercial capsules, and commercial ginger teas were verified by obtaining their single band at Rf = 0.36 ± 0.01 for 6-SHO and Rf = 0.53 ± 0.01 for 6-GIN, compared to standard 6-SHO and 6-GIN. The green RP-HPTLC method was found to be linear, in the range of 100–700 ng/band with R2 = 0.9988 for 6-SHO and 50–600 ng/band with R2 = 0.9995 for 6-GIN. In addition, the method was recorded as “accurate, precise, robust and sensitive” for the simultaneous quantification of 6-SHO and 6-GIN in traditional and ultrasonication-assisted extracts of ginger rhizome, commercial ginger powder, commercial capsules, and commercial ginger teas. The amount of 6-SHO in traditional extracts of ginger rhizome, commercial ginger powder, commercial capsules, and commercial ginger teas was obtained as 12.1, 17.9, 10.5, and 9.6 mg/g of extract, respectively. However, the amount of 6-SHO in ultrasonication-assisted extracts of ginger rhizome, commercial ginger powder, commercial capsules, and commercial ginger teas were obtained as 14.6, 19.7, 11.6, and 10.7 mg/g of extract, respectively. The amount of 6-GIN in traditional extracts of ginger rhizome, commercial ginger powder, commercial capsules, and commercial ginger teas were found as 10.2, 15.1, 7.3, and 6.9 mg/g of extract, respectively. However, the amount of 6-GIN in ultrasonication-assisted extracts of ginger rhizome, commercial ginger powder, commercial capsules, and commercial ginger teas were obtained as 12.7, 17.8, 8.8, and 7.9 mg/g of extract, respectively. Overall, the results of this study indicated that the proposed analytical technique could be effectively used for the simultaneous quantification of 6-SHO and 6-GIN in a wide range of plant extracts and commercial formulations.

Zingiber officinale

Densitometry

Gingerol

Sonication

10.3390/foods9081136

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Citations (31)

Phytochemical and Biological Studies on Some Egyptian Seaweeds

Natural Product Communications (2012)

Khaled N. M. Elsayed Mohamed M. Radwan Sherif H. Hassan Mohamed S. Abdelhameed Ibraheem B. Ibraheem

Extracts of four species of seaweeds, Ulva lactuca L. (green), Liagora farinosa Lamouroux (red), Padina pavonia L. and Turbinaria ornata Turn (brown), were screened for their antimicrobial, and antimalarial activities, and binding affinity for human opioid receptors. Phytochemical analysis led to the isolation and identification of 10 constituents: fucosterol, stearic acid, palmitic acid, palmitoleic acid, oleic acid, myristic acid, p-hydroxybenzoic acid, beta-sitosterol, glycerol-1-olyl-3-palmotyl-2-galactoside, and glycerol-1,3-diolyl, The last two compounds displayed strong binding affinity to delta opioid receptors.

Phytochemical

Myristic acid

Stearic acid

Palmitoleic acid

10.1177/1934578x1200700927

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Citations (11)

CONSTITUENTS OF CANNABIS SATIVA L. XXVIII A REVIEW OF THE NATURAL CONSTITUENTS: 1980-1994

Zagazig Journal of Pharmaceutical Sciences/Zagazig Journal of Pharmaceutical Science (1995)

Samir A. Ross Mahmoud A. Eisohly

Over 11,000 scientific papers have been published on cannabis and its constituents. The purpose of the present review is to update the number of known natural constituents of the Cannabis plant to reach 483 compounds. Emphasis will be placed on those compounds actually isolated or identified from 1980 until 1994.

Cannabis sativa

10.21608/zjps.1995.169714

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Citations (58)

Effect of different fertilizers on the amino acid, fatty acid, and essential oil composition of Nigella sativa seeds.

Saudi Pharmaceutical Journal (2000)

Khalid A. El Sayed Samir A. Ross M. A. ElSohly Malik M. Khalafalla Osama B. Abdel‐Halim

Nigella sativa

Source

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Citations (16)

Echinopsacetylenes A and B, New Thiophenes from Echinops transiliensis

Organic Letters (2011)

Hiroshi Nakano Charles L. Cantrell Leonid K. Mamonov Weste L. A. Osbrink Samir A. Ross

Two new polyacetylene thiophenes, echinopsacetylenes A and B (1 and 2), were isolated from the roots of Echinops transiliensis. The structures of 1 and 2 were elucidated on the basis of spectroscopic analyses and chemical transformations. Echinopsacetylenes A (1) is the first natural product possessing an α-terthienyl moiety covalently linked with another thiophene moiety. Echinopsacetylenes B (2) is the first natural thiophene conjugated with a fatty acid moiety. Echinopsacetylene A (1) showed toxicity against the Formosoan subterranean termite (Coptotermes formosanus).

Moiety

Natural product

10.1021/ol202680a

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Citations (28)

CCDC 1538263: Experimental Crystal Structure Determination

The Cambridge Structural Database (2017)

Raquel Rodríguez-Guzmán Samir A. Ross Frank R. Fronczek

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.

Crystal (programming language)

10.5517/ccdc.csd.cc1nmpdc

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Citations (0)

A new xanthone from the roots of Centaurium spicatum

Phytochemistry Letters (2011)

Mohamed A. El‐Shanawany Gamal A. Mohamed Alaa M. Nafady Sabrin R. M. Ibrahim Mohamed M. Radwan

Xanthone

Antiprotozoal

10.1016/j.phytol.2010.12.008

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Citations (24)

CCDC 1538479: Experimental Crystal Structure Determination

The Cambridge Structural Database (2017)

Raquel Rodríguez-Guzmán Samir A. Ross Abeer Moawad Frank R. Fronczek

10.5517/ccdc.csd.cc1nmxck

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Chemical Constituents, Antimicrobial and Antimalarial Activities ofZanthoxylum monophyllum

Planta Medica (2011)

Raquel Rodríguez-Guzmán Laura Johansmann Fulks Mohamed M. Radwan Charles L. Burandt Samir A. Ross

From the leaves and bark of Zanthoxylum monophyllum, a new lignan, 3-methoxy-3′,4′-methylenedioxylignan-4,8,9,9′-tetraol (1), has been isolated along with 22 known compounds (2–23), fifteen of them reported for the first time from Z. monophyllum. Their chemical structures were elucidated using detailed spectroscopic studies and chemical analysis. All compounds were evaluated for antimicrobial and antiprotozoal activities. Alkaloids bis-[6-(5,6-dihydro-chelerythrinyl)] ether (2) and 6-ethoxy-chelerythrine (4) exhibited strong activity against Aspergillus fumigatus and methicillin-resistant Staphylococcus aureus (MRSA). Compound 4-methoxy-N-methyl-2-quinolone (9) exhibited significant activity against MRSA (IC50 value of 8.0 µM) while compound 5,8,4′-trihydroxy-3,7,3′-trimethoxyflavone (10) showed weak activity against Plasmodium falciparum.

Antiprotozoal

Chelerythrine

Quinolone

Zanthoxylum

10.1055/s-0030-1270782

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Citations (33)