There are plenty of rural tourism resources in Shanxi province and it is possible to exploit them.The tourism e-commerce is becoming more and more important in the forms of current tourism development.There is a natural adaptation between e-commerce and tourism.So it is necessary to promote the rural tourism through constructing and applying the rural tourism e-commerce.During the process,if the integrating development of agricultural production transaction could be joined in,it will be an approach which is innovational and plausible,and it will play an important role in process of the transforming development of Shanxi province.
Epidemic methicillin-resistant Staphylococcus aureus (MRSA) imposes an increasing impact on public health. Due to multi-antibiotics resistance in MRSA strains, there is an urgent need to develop novel therapeutics such as effective monoclonal antibodies (mAbs) against MRSA infections. Staphylococcus aureus surface protein A (SasA), a large surface-located protein (~240 kDa), is one of MSCRAMMs (microbial surface components recognizing adhesive matrix molecules) and a potential target for immunotherapeutic approaches against S. aureus infections. In the present study, we analyzed the sequence of SasA with bioinformatics tools and generated a protective monoclonal antibody (2H7) targeting the conserved domain of SasA. 2H7 was shown to recognize wild-type S. aureus and promote opsonophagocytic killing of S. aureus. In both sepsis and peritoneal infection models, prophylactic administration of 2H7 improved the survival of BALB/c mice challenged by S. aureus strain USA300 and ST239 (prevalent MRSA clones in North America and Asian countries, respectively) and enhanced bacterial clearance in kidneys. Additionally, 2H7 prophylaxis prevented the formation of intraperitoneal abscess in a murine model of peritoneal infection and therapeutic administration of 2H7 showed protective efficacy in a murine sepsis model. Our results presented here provide supporting evidences that an anti-SasA mAb might be a potential component in an antibody-based immunotherapeutic treatment of MRSA infections.
Objective To explore the trend of prevalence of B category infectious diseases in Meizhou city and provide the scientific basis for the control and prevention of infectious diseases.Methods Descriptive epidemiology was used to analyze the data of B category infectious diseases in Meizhou city during 2003-2007.Results During 2003-2007,16 types of 42 821 cases of B category infectious diseases were reported.The average annual incidence rate was 187.45 /100 000.The deadly diseases had 6 types and 163 death cases,with the average annual mortality rate of 0.71 /100 000.Respiratory diseases accounted for 58.65 of total cases and the average annual incidence rate was 109.94 /100 000,and was ranking the first position of various infectious diseases.Blood and sex transmission diseases accounted for 36.56 of the total cases,with the average annual incidence rate of 68.54 /100 000,and was ranking the second position of various infectious diseases.The infectious disease with the highest average annual incidence rate was tuberculosis,and the second was viral hepatitis.Rabies was the highest death toll of infectious diseases,accounted for 63.80 of total deaths.HIV infection rate showed an upward trend.Conclusion The infectious disease control and prevention strategies should focus on tuberculosis,viral hepatitis,rabies and HIV /AIDS.
In developing countries, trauma patients and neonates are vulnerable to Staphylococcus aureus (S. aureus) and Clostridium tetani infections. It has been suggested that a combined vaccine against the two infections may be a reliable and cost‑effective strategy. Previous studies have indicated that the S. aureus surface protein A (SasA) and the C fragment of tetanus neurotoxin (TeNT‑Hc) may be suitable candidates for a vaccine against S. aureus and tetanus infections, respectively. In the present study, mice were immunized with a combined vaccine containing SasA and TeNT‑Hc, which induced a robust immune response to both antigens, and mutual interference between SasA and TeNT‑Hc was not observed. In the S.aureus challenge model, the combined vaccine fully protected BALB/c mice against lethal intraperitoneal challenges with 3x109 colony‑forming units of a methicillin‑resistant S. aureus USA300 strain. In the TeNT challenge model, the combined vaccine conferred complete protection against a lethal dose of (2x103) xLD50 tetanus toxin. These results implied that SasA and TeNT‑Hc promising components for a combined vaccine against S. aureus and tetanus infections.
Staphylococcus aureus is the most common cause of hospital-acquired bacteremia. Due to emergence of antibiotic-resistant strains, these infections present a serious public health threat. In this study, to develop a broadly protective vaccine, we tested whether immune responses induced by several proteins associated with S. aureus toxicity could protect mice from lethal challenge with human clinical S. aureus isolate USA300. We found that the surface protein A (SasA) of S. aureus could protect mice from lethal challenge of the bacteria.
Objective To explore the epidemiological characteristics of rabies in Meizhou city and provide the scientific basis for the control and prevention of rabies.Method The data of epidemic situation and personal survey from 2001 to 2006 in Meizhou was epidemiologically analyzed.Result There were 127 cases of rabies in Meizhou between 2001 and 2006.The annual incidence was 0.43/100000,with a mortality of 100%.There was no obvious peak season.The infected male to female ratio was 1.76:1.57.48% of the infected people were farmers.Conclusion The rabies epidemic situation is grave in Meizhou city.The occurrence was mainly in Wuhua county.A high density of dogs,low immunization rate,inappropriate treatment and limited health knowledge of the general public were the major cause of the outbreak of rabies.Strengthening of managing the dogs,increasing the vaccination rate of the dogs and the health education in general public are the focus of our work in the future.
Objective To analyze the HIV/AIDS epidemiological characteristics in Meizhou city and set up the control measures of HIV/AIDS. Methods Surveillance and control measures of HIV/AIDS in Meizhou city were from 1992 to 2005. Results The first case of HIV infection was reported in 1992. A total number of 29 cases of HIV infections were reported from 1992 to 2005 and 17 cases died . HIV infections mainly occurred in male (79.13%), mainly 20-49 years old male (75.86%). The main transmission route was sexual transmission, accounting for 62.07%. Blood-born transmission was 13.79%. The transmission from mother to infant was 3.45%. Conclusion It is a critical moment to control and prevent HIV/AIDS in Meizhou city. The strategies should focus on HIV surveillance, control and prevention measures, and the implementation of health education of the public.
The process of preparation for the p-tert-butylcatechol is studied,while methyl(t-butylether) is used as alkylation agent.The effect of process parameters on reaction result is researched.The optimum condition of the reaction is obtained by orthogonal experiment,when reaction temperature is 110 ℃,reaction time is 2.5 h,the molar ratio of catechol to MTBE and H_2SO_4 is 1∶1.5∶1.225,the yield of the TBC is above 72.26%.
Objective To analyze the epidemiological characteristics of suddenly emerging public health events in Meizhou City to provide scientific basis for their prevention and control.Methods Data of suddenly emerging public health events from 2002 to 2007 were collected and analyzed by descriptive epidemiological method.Results There were 44 emerging public health events with 2?267 cases and 10 deaths in Meizhou City during 2002 to 2007, 20 of them caused by infectious diseases and 24 by food poisoning. The peak of events mainly was in March to June of each year and most occurred in schools (47.73%).Conclusion Situation of emerging public health events in Meizhou City was not so optimistic.More attention should be paid to prevention and control for infectious diseases and food poisoning, especially in key groups such as students, farmers, and so on.
Objective To investigate the epidemiological characteristics of Norwalk-like virus gastroenteritis in Meizhou city and provide the scientific basis for Norwalk-like virus gastroenteritis control and prevention.Method Descriptive epidemiological method was used to analyze the Norwalk-like virus gastroenteritis reported from 2004 to 2006.Result 382 cases were reported from the schools.All outbreaks were occurred in winter and spring.Nausea,vomiting,abdominal pain,diarrhea and fever were the main symptoms.Norwalk-like virus antigen was detected in some stool samples during the outbreak.Conclusion Norwalk-like virus gastroenteritis mainly occurred in school.Providing clean water for drinking and preventing food contamination are the prevention and control measures for norwalk-like virus gastroenteritis.
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