Irina Malikova

Centre National de la Recherche Scientifique

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Jean Pelletier

Hôpital de la Timone

Jean‐Philippe Ranjeva

Aix-Marseille Université

Bertrand Audoin

Hôpital de la Timone

Patrick J. Cozzone

Agency for Science, Technology and Research

Françoise Reuter

Centre National de la Recherche Scientifique

Sylviane Confort‐Gouny

Centre de Résonance Magnétique Biologique et Médicale

Audrey Rico

Centre National de la Recherche Scientifique

Wafaa Zaaraoui

Centre de Résonance Magnétique Biologique et Médicale

Elisabeth Soulier

Centre de Résonance Magnétique Biologique et Médicale

Patrick Viout

Centre National de la Recherche Scientifique

Cooperative Institutions

Centre National de la Recherche Scientifique

Inserm

Hôpital de la Timone

Aix-Marseille Université

Centre de Résonance Magnétique Biologique et Médicale

Assistance Publique Hôpitaux de Marseille

Assistance Publique – Hôpitaux de Paris

Sorbonne Université

Université Claude Bernard Lyon 1

Observatoire Français de la Sclérose en Plaques

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The onset location of multiple sclerosis predicts the location of subsequent relapses

Journal of Neurology Neurosurgery & Psychiatry (2008)

Ellen M. Mowry Suha Deen Irina Malikova Jean Pelletier Peter Bacchetti

Demyelinating events in relapsing-remitting multiple sclerosis (RRMS) can involve several locations in the central nervous system. We sought to determine if initial clinical demyelinating event (IDE) location predicts subsequent clinical relapse locations in early RRMS.We identified all RRMS patients from two large MS clinics who were seen within 1 year of disease onset. Logistic regression was performed with the outcome defined as the second or third exacerbation location and the predictor defined as IDE+/-second event location.195 patients with at least two clinical exacerbations were identified. There was an increased odds of a patient's second relapse occurring in the spinal cord if the IDE was in the spinal cord (odds ratio (OR) = 3.79, 95% CI 2.06 to 7.00, p<0.001). There was more than a sixfold increase in the odds of a patient's second relapse occurring in the optic nerve if the IDE was in the optic nerve (OR = 6.18, 95% CI 2.90 to 13.18, p<0.001). These associations remained similar after adjusting for treatment and patient characteristics. If the IDE and second event were both in the same location (spinal cord, optic nerve or brainstem/cerebellum), the third event was likely to remain in that location.Patients with RRMS have relatively localised clinical relapses. It remains to be determined if genetic or biological processes are responsible for this pattern.

10.1136/jnnp.2008.157305

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Citations (48)

Treatment of progressive forms of multiple sclerosis by cyclophosphamide: a cohort study of 490 patients

Journal of the Neurological Sciences (2003)

Hélène Zephir de Sèze Alain Duhamel Marc Debouverie Patrick Hautecœur

10.1016/j.jns.2003.11.004

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Citations (71)

Intact subliminal processing and delayed conscious access in multiple sclerosis

Neuropsychologia (2007)

Françoise Reuter Antoine Del Cul Bertrand Audoin Irina Malikova Lionel Naccache

Subliminal stimuli

Backward masking

Visual masking

Visual processing

Priming (agriculture)

10.1016/j.neuropsychologia.2007.04.010

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Citations (27)

Voxelwise analysis of conventional magnetic resonance imaging to predict future disability in early relapsing–remitting multiple sclerosis

Multiple Sclerosis Journal (2012)

D. Wybrecht Françoise Reuter Wafaa Zaaraoui Anthony Faivre Lydie Crespy

Background: The ability of conventional magnetic resonance imaging (MRI) to predict subsequent physical disability and cognitive deterioration after a clinically isolated syndrome (CIS) is weak. Objectives: We aimed to investigate whether conventional MRI changes over 1 year could predict cognitive and physical disability 5 years later in CIS. We performed analyses using a global approach (T 2 lesion load, number of T 2 lesions), but also a topographic approach. Methods: This study included 38 patients with a CIS. At inclusion, 10 out of 38 patients fulfilled the 2010 revised McDonald’s criteria for the diagnosis of multiple sclerosis. Expanded Disability Status Scale (EDSS) evaluation was performed at baseline, year 1 and year 5, and cognitive evaluation at baseline and year 5. T 2 -weighted MRI was performed at baseline and year 1. We used voxelwise analysis to analyse the predictive value of lesions location for subsequent disability. Results: Using the global approach, no correlation was found between MRI and clinical data. The occurrence or growth of new lesions in the brainstem was correlated with EDSS changes over the 5 years of follow-up. The occurrence or growth of new lesions in cerebellum, thalami, corpus callosum and frontal lobes over 1 year was correlated with cognitive impairment at 5 years. Conclusion: The assessment of lesion location at the first stage of multiple sclerosis may be of value to predict future clinical disability.

Clinically isolated syndrome

10.1177/1352458512442991

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Citations (12)

Английский язык (контрольные задания) : пособие

БГУИР eBooks (2013)

Т. Г. Шелягова С. И. Лягушевич И. И. Илюкевич Irina Malikova А. М. Лазаренко

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Les troubles cognitifs au stade le plus précoce de la sclérose en plaques : réalité et devenir

Revue Neurologique (2010)

Françoise Reuter Wafaa Zaaraoui Audrey Rico Irina Malikova Jean‐Philippe Ranjeva

10.1016/s0035-3787(10)70021-7

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Electrophysiological correlates of access to consciousness in early multiple sclerosis patients.

NeuroImage (2009)

Françoise Reuter Catherine Liégeois‐Chauvel Patrick Marquis Antoine Del Cul Irina Malikova

10.1016/s1053-8119(09)70032-1

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Utilisation de la mitoxantrone dans les formes malignes inaugurales de sclérose en plaques. Étude observationnelle de 30cas. Évaluations cliniques et IRM à un an

Revue Neurologique (2008)

Sophie Ory Marc Debouverie Emmanuelle Le Page Jean Pelletier Irina Malikova

Mitoxantrone

10.1016/j.neurol.2008.04.008

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Citations (8)

Les troubles cognitifs

Revue Neurologique (2009)

Françoise Reuter Bertrand Audoin Audrey Rico Irina Malikova Jean‐Philippe Ranjeva

Verbal fluency test

Cognitive test

Cognitive Decline

10.1016/s0035-3787(09)72122-8

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Citations (6)

Alteration of CD1 expression in multiple sclerosis

Clinical & Experimental Immunology (2012)

Sébastien Bine Alain Haziot Irina Malikova Jean Pelletier Dominique Charron

Studies of multiple sclerosis (MS) have concentrated mainly on antigen presentation of peptides derived from the myelin sheath, while the implication of lipid antigen has been less explored in this pathology. As the extracellular environment regulates expression of the lipid antigen-presenting molecule CD1, we have examined whether sera from patients alters CD1 surface expression in monocyte-derived dendritic cells. We have shown that: (i) CD1 group 1 proteins were highly expressed in the presence of MS sera; (ii) sera from MS patients differentially regulated CD1 group 1 versus CD1 group 2 molecular expression; and (iii) CD1 was expressed strongly in monocytes from MS patients under immunosuppressive treatment. Overall, these results reveal that CD1 expression is modified in MS and provide novel information on the regulation of lipid antigen presentation in myeloid cells.

CD1

Monocyte

10.1111/j.1365-2249.2012.04586.x

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Citations (2)