Michael Daniels

Northwestern University

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Bette Korber

Los Alamos National Laboratory

Amy Whetsell

Pediatrics and Genetics

David D. Ho

Columbia University

Richard A. Koup

National Institute of Allergy and Infectious Diseases

Jörg Timm

Institute of Virology of the Slovak Academy of Sciences

Todd M. Allen

Ragon Institute of MGH, MIT and Harvard

Will Fischer

Los Alamos National Laboratory

Julian Schulze zur Wiesch

University Medical Center Hamburg-Eppendorf

Yunzhen Cao

Aaron Diamond AIDS Research Center

B.D. Walker

University of North Carolina at Chapel Hill

Cooperative Institutions

Massachusetts General Hospital

Harvard University

Ragon Institute of MGH, MIT and Harvard

Los Alamos National Laboratory

Howard Hughes Medical Institute

Northwestern University

Aaron Diamond AIDS Research Center

Düsseldorf University Hospital

Heinrich Heine University Düsseldorf

Santa Fe Institute

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Adaptive Evolution of Human Immunodeficiency Virus-Type 1 During the Natural Course of Infection

Science (1996)

Steven M. Wolinsky Bette Korber Avidan U. Neumann Michael Daniels Kevin Kunstman

The rate of progression to disease varies considerably among individuals infected with human immunodeficiency virus-type 1 (HIV-1). Analyses of semiannual blood samples obtained from six infected men showed that a rapid rate of CD4 T cell loss was associated with relative evolutionary stasis of the HIV-1 quasispecies virus population. More moderate rates of CD4 T cell loss correlated with genetic evolution within three of four subjects. Consistent with selection by the immune constraints of these subjects, amino acid changes were apparent within the appropriate epitopes of human leukocyte antigen class I-restricted cytotoxic T lymphocytes. Thus, the evolutionary dynamics exhibited by the HIV-1 quasispecies virus populations under natural selection are compatible with adaptive evolution.

Viral quasispecies

Viral evolution

10.1126/science.272.5261.537

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Citations (579)

P.191 HLA-associated sequence polymorphisms in HCV reveal the reproducibility of immune responses and constraints on viral evolution

Journal of Clinical Virology (2006)

Jörg Timm B. Li Tanmoy Bhattacharya Michael Daniels Laura L. Reyor

Docosapentaenoic acid

10.1016/s1386-6532(06)80371-9

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