Du Xiang

Fudan University

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Wei Chen

National University of Singapore

Cheng Han

Shenzhen University

Yue Zheng

Sun Yat-sen University

Goki Eda

National University of Singapore

Zehua Hu

Zhongkai University of Agriculture and Engineering

Bo Lei

National University of Singapore

Jing Wu

Institute of Materials Research and Engineering

Li Wang

Nanchang University

Yi Cao

Soochow University

Yanan Wang

University of Nebraska–Lincoln

Cooperative Institutions

Fudan University

149

Fudan University Shanghai Cancer Center

National University of Singapore

Shanghai Medical College of Fudan University

Sun Yat-sen University

Chinese Academy of Sciences

Zhongshan Hospital

Shanghai Jiao Tong University

The First Affiliated Hospital, Sun Yat-sen University

Chinese Academy of Medical Sciences & Peking Union Medical College

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Significantly enhanced optoelectronic performance of tungsten diselenide phototransistor via surface functionalization

Nano Research (2017)

Bo Lei Zehua Hu Du Xiang Junyong Wang Goki Eda

Tungsten diselenide

Surface Modification

Photocurrent

Ambipolar diffusion

Photodiode

Diselenide

10.1007/s12274-016-1386-1

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Citations (36)

[Secondary vaginal adenocarcinoma: a clinicopathologic study of 55 cases].

PubMed (1994)

Xiaoyan Zhou Du Xiang

A retrospective clinicopathologic study of 55 cases with secondary vaginal adenocarcinoma occurring in 26 years is presented. The results showed that they represent 2.6% of all gynecological adenocarcinomas. The symptoms included irregular vaginal bleeding after menopause. 92.5% of apical lesions were metastasized from the upper genital tract, and 90.0% of the posterior lesions were from the gastrointestinal tract. Pathologically the secondary vaginal adenocarcinoma showed extensive solid areas and aggressive growth pattern. About two thirds were recurrences or metastases in vagina after removal of primary lesions, 80.8% occurred within first 3 years. The mean 3-year and 5-year survival rate was 30.8% and 18% respectively. It is emphasized that vaginal examination with cytologic screening in risk periods is necessary.

Genital tract

Vaginal bleeding

Female circumcision

Sex organ

Vaginal disease

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Citations (1)

Classification and Tie2 mutations in spinal and soft tissue vascular anomalies

Gene (2015)

Mei Zhou Renbing Jiang Gang Zhao Lisha Wang Hua Wang

Angiopoietin receptor

Nonsense mutation

Vascular malformation

10.1016/j.gene.2015.06.048

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Citations (8)

[Expression of Six1 and Six4 in esophageal squamous cell carcinoma and their correlation with clinical prognosis].

PubMed (2013)

Wei Qiao Wei Yu Kuai Le Zhao Xiao Fu Zheng Zhu

Six1 and Six4 are expressed in several tumors, and associated with tumor progress and poor prognosis. The aim of this study was to investigate the expression of Six1 and Six4 in esophageal squamous cell carcinoma (ESCC), and to evaluate their correlation with the clinicopathological factors and prognosis.Tissue microarray technology and immunohistochemical method (EnVision) were used to detect the expression of Six1 and Six4 in the tumor tissues and corresponding adjacent normal epithelium of esophagus from 292 ESCC patients.Among the 292 ESCC patients, the positive rates of Six1 and Six4 protein expression in tumor tissues were 72.9% (213/292) and 56.2% (164/292), respectively, significantly higher than the expression rate of 33.2% (97/292) and 32.5% (95/292) in adjacent normal epithelium of esophagus (P < 0.05). Chi square test showed that the expression of Six1 protein was related to tumor size, depth of tumor invasion and patient survival status; higher Six4 protein expression level was related to poor differentiation and increased depth of invasion. Single factor Log-rank analysis revealed that gender, TNM stage, Six1 protein expression level were related to the overall survival of ESCC patients (P < 0.05), while the five-year survival rate was significantly higher in the Six1-negative group than the Six1-positive group [51.9% (41/79) vs. 43.7% (93/213)]. Multi-factor Cox proportional risk model analysis showed that TNM stage and positive expression of Six1 were independent prognostic factors for ESCC patients (P < 0.05).Six1 and Six4 are highly expressed in ESCC. Their expression levels are closely related to the progress and prognosis of ESCC. Over-expression of Six1 is related to poor prognosis in ESCC patients. Thus, Six1 could be used as an important prognostic indicator for ESCC patients.

Tissue microarray

10.3760/cma.j.issn.0529-5807.2013.07.004

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Citations (9)

Extending in-sensor computing from static images to dynamic motions

Nature Electronics (2023)

Du Xiang Tao Liu

10.1038/s41928-023-01070-3

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Citations (1)

[Study on the germline mutation of MSH6 gene in Chinese hereditary nonpolyposis colorectal cancer pedigrees using PCR based sequencing].

PubMed (2007)

Shi Yan Yan Xiao Zhou San Jun Cai Bao Hua Yu Tai Ming Zhang

To detect the germline mutation of mismatch repair gene (MSH6) in hereditary nonpolyposis colorectal cancer (HNPCC) kindreds fulfilling different clinical criteria.The germline mutations of MSH6 gene were detected by PCR based DNA sequencing in 39 unrelated HNPCC probands fulfilling different clinical criteria in which MSH2 and MLH1 mutations were excluded. The exons with missense mutations were analyzed using PCR sequencing in the germline genomic DNA of 137 healthy persons. The expression of MSH6 protein was detected by Envision immunohistochemistry staining in the tumor tissues of the mutational probands.Six germline mutations of MSH6 gene were detected in 39 probands of Chinese HNPCC kindreds, and the mutations distributed in the exon 4, 6, 9 and 10. Four out of six mutations were missense mutation, one was nonsense mutation and the remaining one was insertion mutation in splice site. The results of sequecing for the exons with above four missense mutations in 137 healthy persons' genomic DNA showed that 5 of 137 persons had the missense mutation of c.3488 A to T at codon 1163 of the 6th exon. The mutational rate was approximately 3.65% (5/137), so the mutation could be a single nucleotide polymorphism (SNP). The remaining missense mutations were not found in any germline genomic DNA of 137 healthy persons. Positive expression of MSH6 protein had been identified in the tumor of the SNP proband while the tumors had negative MSH6 protein expression in the rest probands of germline mutation MSH6 gene. The types of mutations and their potential significance were determined by comparing the following databases: http://www.ncbi.nlm.nih.gov/, http://www.ensembl.org/homo-sapies, and http://www.insight-group.org. Five out of the six mutations had not been reported previously and they were new pathological mutations, the rest one was a new SNP.Germline mutations of MSH6 gene may play an important role in Chinese HNPCC kindreds fulfilling different clinical criteria. It is necessary to analyze the germline mutations of MSH6 gene using sequencing to identify HNPCC families in the probands in which MSH2 and MLH1 mutation were excluded.

Nonsense mutation

MSH6

Proband

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Citations (0)

[Analysis of c-kit gene mutations in gastrointestinal stromal tumors].

PubMed (2004)

Ying Hou Meng Sun Yun shan Tan Yong Wei Xiao Lu

To define the frequency and spectrum of c-kit gene mutations in gastrointestinal stromal tumors (GIST).Fifty two cases of GIST and 28 cases of other tumors were examined for mutations in exon 11, 9 and 13 of c-kit gene using PCR amplification and DNA sequencing.Fourteen out of 25 malignant GIST (56%), while 2 of 27 benign and borderline GIST (7.4%) revealed mutations in exon 11 of c-kit gene (P < 0.01). Most of the mutations consisted of in-frame deletion or replication from 3 to 48 bp in heterozygous and homozygous fashions, but none of the mutations disrupted the downstream reading frame of the gene. Point mutation and deletion concentrated at 550 - 570 codons but replication clustered within 570 - 585 codons. The mutation pattern in recurrence tissues was the same as the primary ones. Normal tissues adjacent to GIST with or without c-kit gene mutations showed wild type c-kit gene sequence. No mutation was found in exon 9 and 13. Neither c-kit gene expression nor gene mutations was found in 3 leiomyomas, 8 leiomyosarcomas, 2 schwannomas, 2 intra-abdomenal fibromitoses and 8 adenocarcinomas.The mutations in exon 11 of c-kit gene might partially represent one of the molecular mechanisms of GIST. It can be used as a marker for distinguishing benignancy and malignancy of GIST. The mutations did not involve the reading frame. Except for long frame deletion, most mutations also did not affect protein expression. Mutation of c-kit gene in GIST provides a new genotypic marker to distinguish GIST from authentic leiomyomas, leiomyosarcomas, schwannomas and etc.

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Out‐of‐Plane Homojunction Enabled High Performance SnS₂ Lateral Phototransistor

Advanced Optical Materials (2020)

Jing Gao Hang Yang Hongying Mao Tao Liu Yue Zheng

Abstract 2D materials have been extensively applied in electronic and optoelectronic devices due to their unique and extraordinary electrical and optical properties. Among them, tin disulfide (SnS 2 ) has attracted enormous research interests due to its low‐cost, earth‐abundant, environment friendly properties as well as superior performance in photodetectors. Here, an outstanding in‐plane SnS 2 phototransistor with an out‐of‐plane built‐in electric field enabled by molybdenum oxide (MoO 3 ) surface functionalization is demonstrated. The photocarriers are generated and effectively separated by the vertical electric field, leading to a high photoresponsivity of 2.3 × 10 3 A⋅W −1 , photoconductive gain of >10 5 , external quantum efficiency exceeding 8%. It also demonstrates a low noise power density, revealing an ultrasensitive photodetection with specific detectivity up to 3.2 × 10 12 Jones. The formation of the out‐of‐plane built‐in electric field is validated by the output electrical transport measurement of SnS 2 vertical transistor, and further corroborated by in situ ultraviolet photoelectron spectroscopy and X‐ray photoelectron spectroscopy characterizations. The findings promise surface functionalization as an effective approach to induce an internal electric field in 2D multilayer SnS 2 towards its application in high performance photodetection.

Photodetection

Photodiode

Photoconductivity

Ultraviolet photoelectron spectroscopy

Quantum Efficiency

Homojunction

Surface Modification

10.1002/adom.201901971

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Citations (31)

Anomalous Broadband Spectrum Photodetection in 2D Rhenium Disulfide Transistor

Advanced Optical Materials (2019)

Du Xiang Tao Liu Junyong Wang Peng Wang Lin Wang

Abstract 2D transition metal dichalcogenide (TMD)‐based phototransistors generally work under photoconductive, photovoltaic, or photogating mode, in which photocarriers are generated from band‐to‐band excitation. Nevertheless, due to the relatively large bandgap, most TMD phototransistors working under these modes are restricted in visible spectrum. Here, photodetection in 2D multilayer rhenium disulfide (ReS 2 ) transistor via bolometric mode, which relies on light heating induced conductance change instead of band‐to‐band photoexcitation is reported, making it possible for sub‐bandgap photon detection. The bolometric effect induced photoresponse is first revealed by an anomalous sign switching of photocurrent from positive to negative while increasing gate voltage under visible light, which is further validated by the temperature dependent electrical transport measurements. The phototransistor exhibits remarkable photoresponse under infrared regime, beyond the optical bandgap absorption edge of the ReS 2 flake. Additionally, it demonstrates a low noise equivalent power, less than 5 × 10 −2 pW Hz −1/2 , which is very promising for ultra‐weak light detection. Moreover, the response time is below 3 ms, nearly 3–4 orders of magnitude faster than previously reported ReS 2 photodetectors. The findings promise bolometric effect as an effective photodetection mode to extend the response spectrum of large bandgap TMDs for novel and high‐performance broadband photodetectors.

Photodetection

Photocurrent

Photoconductivity

Photoexcitation

Visible spectrum

10.1002/adom.201901115

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Citations (48)

Strongly Modulated Ambipolar Characteristics of Few-layer Black Phosphorus in Oxygen

arXiv (Cornell University) (2016)

Cheng Han Zehua Hu Jialin Zhang Fang Hu Du Xiang

Two-dimensional black phosphorus has been configured as field-effect transistors, showing an intrinsic symmetric ambipolar transport characteristic. Here, we demonstrate the strongly modulated ambipolar characteristics of few-layer black phosphorus in oxygen. Pure oxygen exposure can dramatically decrease the electron mobility of black phosphorus without degrading the hole transport. The transport characteristics can be nearly recovered upon annealing in Argon. This reveals that oxygen molecules are physisorbed on black phosphorus. In contrast, oxygen exposure upon light illumination exhibits a significant attenuation for both electron and hole transport, originating from the photoactivated oxidation of black phosphorus, which is corroborated by in situ X-ray photoelectron spectroscopy characterization. Our findings clarify the predominant role of oxygen in modulating ambipolar characteristics of black phosphorus, thereby providing deeper insight to the design of black phosphorus based complementary electronics.

Ambipolar diffusion

Black Phosphorus

Electron Mobility

10.48550/arxiv.1603.02799

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Citations (5)