Peter Graw

Universitäre Psychiatrische Kliniken Basel

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Co-Authors

Anna Wirz‐Justice

University of Basel

Kurt Kräuchi

University of Basel

Christian Cajochen

University of Basel

Markus Gastpar

University of Duisburg-Essen

D Ladewig

Universitäre Psychiatrische Kliniken Basel

W. Pühringer

Universitäre Psychiatrische Kliniken Basel

Daniel P. Brunner

Klinik Hirslanden

Verena Lacoste

Universitäre Psychiatrische Kliniken Basel

Georg Leonhardt

University Hospital Carl Gustav Carus

G Hole

University of Sussex

Cooperative Institutions

Universitäre Psychiatrische Kliniken Basel

University of Basel

University of Zurich

University Psychiatric Hospital

University Hospital of Basel

University of Vienna

Klinik und Poliklinik für Psychiatrie und Psychotherapie

Vienna General Hospital

Universitäre Psychiatrische Dienste Bern

University Hospital of Zurich

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‘Natural’ light treatment of seasonal affective disorder

Journal of Affective Disorders (1996)

Anna Wirz‐Justice Peter Graw Kurt Kräuchi Asita Sarrafzadeh Judie English

Light therapy

10.1016/0165-0327(95)00081-x

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Citations (170)

Diurnal variation of symptoms in seasonal affective disorder

Psychiatry Research (1991)

Peter Graw Kurt Kräuchi Anna Wirz‐Justice W Pöldinger

Diurnal temperature variation

Variation (astronomy)

Melancholic depression

10.1016/0165-1781(91)90110-b

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Citations (24)

Circadian and wake-dependent modulation of fastest and slowest reaction times during the psychomotor vigilance task

Physiology & Behavior (2004)

Peter Graw Kurt Kräuchi Vera Knoblauch Anna Wirz‐Justice Christian Cajochen

Psychomotor vigilance task

Vigilance (psychology)

Nap

Crossover study

10.1016/j.physbeh.2003.12.004

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Citations (201)

Correspondence

Journal of Affective Disorders (1999)

Anna Wirz‐Justice Peter Graw H Röösli Gaétan Glauser Jörg Fleischhauer

10.1016/s0165-0327(98)00128-1

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Citations (14)

Verschiedene Schritte einer Konstruktvalidierung des Basler Drogen- und Alkoholfragebogens (BDA)

Pharmacopsychiatry (1984)

Peter Graw D Ladewig V. Hobi

In a first study we deveoped a test (BDA) for measuring the degree of dependence on alcohol, medicaments and drugs in alcoholics as well as drug addicts. The present study analysed this test according to the principles of construct validity.The aim was to create a test with those items that optimally fulfil some of the following criteria. This was achieved with 22 out of the original 59 items of the test.

10.1055/s-2007-1017414

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Citations (8)

Dose relationships of morning bright white light in seasonal affective disorders (SAD)

Experientia (1987)

Anna Wirz‐Justice A. Schmid Peter Graw Kurt Kräuchi P Kielholz

White (mutation)

Crossover study

Depression

10.1007/bf02143590

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Citations (59)

Seasonality in affective disorders in Switzerland

Acta Psychiatrica Scandinavica (2003)

Anna Wirz‐Justice Peter Graw Kurt Kräuchi H. R. Wacker

Objective: To estimate the prevalence of seasonal affective disorder (SAD) and its subsyndromal form (S‐SAD) in Switzerland (47°N). Method: A representative sample from all three language areas of Switzerland ( n = 980) were given a structured telephone interview using the extended Seasonal Pattern Assessment Questionnaire (SPAQ+). A smaller, but also representative sample in the city of Basel filled in the SPAQ+ form as well as undergoing a structured diagnostic interview. Results: In this Swiss sample, 2.2% of the population presented with symptom severity of SAD, 8.9% with S‐SAD. In Basel, a much higher prevalence of SAD was found. Seasonal problems occurred more often in patients with the Diagnostic and Statistical Manual (DSM)‐III diagnosis of major affective disorders than in those with pure anxiety disorders or no psychiatric diagnosis. Conclusion: These estimates for SAD in Switzerland are similar to those found in the Zürich Study, using other methods, and for populations in the UK, with the limitations inherent in retrospective questionnaire studies.

Telephone interview

Sample (material)

Generalized anxiety

10.1034/j.1600-0447.108.s418.18.x

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Citations (37)

Intravenous L-5-Hydroxytryptophan in Normal Subjects: An Interdisciplinary Precursor Loading Study: Part III: Neuroendocrinological and biochemical Changes

Pharmacopsychiatry (1976)

Anna Wirz‐Justice W. Pühringer Verena Lacoste Peter Graw Markus Gastpar

In a precursor study with i.v. 1-5HTP (Ro 3-5940) after peripheral decarboxylase inhibition with benserazide (Ro 4-4602) in healthy human subjects the following biochemical changes were found: 1. Prolactin release was stimulated by benserazide alone, and further stimulated by 1-5HTP (more in women than in men). 2. Basal growth hormone secretion was not affected by benserazide, but was significantly stimulated by 1-5HTP, often to extremely high values. The time course of growth hormone release followed that of mood elevation in 8/11 subjects (and was even correlated in 3), providing data for speculation as to the interrelationships between affective state and neuroendocrinological function. 3. Cortisol levels were higher than normal throughout the experiment, but followed the diurnal decline. A late stimulation of cortisol release after 1-5HTP was observed. 4. The lack of increased platelet serotonin after 1-5HTP indicated efficacious peripheral decarboxylase inhibition by benserazide. 5. Benserazide treatment inhibited platelet MAO activity in certain subjects. Short-term increases in MAO activity after 1-5HTP were observed. 6. 1-5HTP displaced albumin-bound tryptophan by 20%.

Benserazide

Decarboxylase inhibitor

Basal (medicine)

10.1055/s-0028-1094502

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Citations (24)

[Simultaneous improvement of mood and release of growth hormone by L-5-hydroxytryptophan (Ro 3-5940) in normal subjects (author's transl)].

PubMed (1978)

Anna Wirz‐Justice H. Feer W. Pühringer Peter Graw Lacoste

Infusion of a new soluble ester of L-5-hydroxytryptophan produced euphoria in 34/35 experiments in healthy subjects. Parallel measurements of growth hormone and mood changes showed a similar rise and fall of these two parameters in 8/11 subjects. These results indicate that central stimulatory serotoninergic mechanisms (in addition to the well-known dopaminergic and alpha-adrenergic stimulation) play a role in the control of growth hormone release.

Euphoriant

5-Hydroxytryptophan

Source

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Citations (1)

Sleep deprivation response in seasonal affective disorder during a 40-h constant routine

Journal of Affective Disorders (1998)

Peter Graw

Depression

Light therapy

Clinical Global Impression

10.1016/s0165-0327(97)00142-0

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Citations (36)