Luda Yan

Guangzhou University

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Wenbin Fu

Guangzhou University of Chinese Medicine

Baile Ning

Guangzhou University of Chinese Medicine

Qiaoyun Yu

Guangzhou University of Chinese Medicine

Rundong Tang

Guangzhou University of Chinese Medicine

Yidan Qiu

South China Normal University

Yuchen Liu

Shenzhen Second People's Hospital

Junquan Liang

Guangzhou University of Chinese Medicine

Delong Zhang

North University of China

Peng Zhou

Institute of Process Engineering

Sheng-Yong Su

Guangxi University of Chinese Medicine

Cooperative Institutions

Guangzhou University of Chinese Medicine

Guangzhou University

Shenzhen Bao'an District People's Hospital

Shanghai Jiao Tong University

Sichuan University

Huazhong University of Science and Technology

South China Normal University

Sun Yat-sen University

Chinese Academy of Medical Sciences & Peking Union Medical College

Chinese Academy of Sciences

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Effects of Horticultural Therapy Combined with Intradermal Needle Therapy on Generalised Anxiety, Cortical Excitability and HPA-related Hormones in an Isolated Population during the COVID-19 Pandemic: Protocol for a Randomised Controlled Clinical Trial

Research Square (Research Square) (2023)

Jiaxin Zhu Dongmei Cai Jiayi Yan Jiamin Chen Luda Yan

Abstract Introduction: Coronavirus disease 2019 (COVID-19) is a novel, highly infectious disease that is a severe danger to human life and has spawned a worldwide public health emergency. Most countries have implemented measures of isolation to prevent the spread of COVID-19, but related studies have shown that isolation increases the risk of anxiety, thereby affecting an individual’s physical and mental health. Simple and effective therapies for anxiety among quarantined populations need to be further explored. Horticultural activities can divert people's attention and alleviate negative emotions. Acupuncture is a conventional alternative therapy that has demonstrated efficacy in mood stabilization. The current study aimed to explore the clinical efficacy of combined Chinese and Western medicine therapies in alleviating anxiety among quarantined individuals during a pandemic. Methods In this prospective, randomised controlled trial (RCT), 150 patients with generalised anxiety disorder will be recruited from the Seventh Clinical College affiliated to Guangzhou University of Chinese Medicine. Eligible subjects will be randomly divided into the horticultural group (n = 50), intradermal acupuncture group (n = 50) and combined treatment group (n = 50). The horticulture group will engage in horticultural activity after basic treatment; the intradermal needle group will undergo intradermal needling after basic treatment; and the combined group will engage in horticultural activity and undergo intradermal needling after basic treatment. The treatments will be provided once a week for 8 weeks. The main outcome will be scores on the Hamilton Anxiety Scale (HAMA); secondary outcomes will include scores on the Self-Assessment Scale for Anxiety (SAS) and Pittsburgh Sleep Quality Index Scale (PSQI), serum indexes, and cortical excitability. All scales will be evaluated at baseline, at 2, 4, 6, and 8 weeks of treatment, and at follow-up; serological indicators and cortical excitability will be assessed at baseline and during week eight of treatment. Discussion The result of the experiment will help to clarify the therapeutic effects of horticultural therapy combined with intradermal needling on anxiety among isolated individuals and to elucidate the therapeutic mechanisms of this combined treatment among patients with anxiety. The purpose of this research is to eventually incorporate this combination approach into a treatment programme for anxiety, thereby significantly reducing the burden of mood disorders in the general population during public health emergencies. Trial registration: ClinicalTrials.gov ChiCTR2200066321. Registered on December 1, 2022

Dry Needling

Pandemic

Isolation

10.21203/rs.3.rs-3725748/v1

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[Evaluation of the reporting quality of randomized controlled trials of acupuncture for depression based on CONSORT statement, STRICTA criteria and SHARE checklist].

PubMed (2024)

Zhongxian Li Haiyan Xu Luda Yan Yi Luo Liang Zhang

To evaluate the reporting quality of randomized controlled trials (RCTs) of acupuncture for depression.

Depression

Statement (logic)

10.13703/j.0255-2930.20240110-k0003

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Efficacy of the Integrative Acupuncture and Moxibustion Treatment in Patients With Major Depressive Disorder: The Study Protocol for a Multicenter, Single-Blinded, Randomized Trial in China

Frontiers in Medicine (2022)

Yuan Zhang Yamin Liu Baile Ning Luda Yan Lihua Wu

Antidepressants are the front-line treatments for major depressive disorder (MDD), but remain unsatisfactory in outcome. An increasing number of patients are interested in acupuncture and moxibustion treatment as complementary therapies. This study aims to evaluate the efficacy and safety of integrative acupuncture and moxibustion (iAM) treatment in patients with MDD.This multicenter, single-blind, 2 × 2 factorial randomized trial will enroll 592 patients with MDD of moderate severity from nine hospitals. All patients will be randomized, in a ratio of 2:2:2:1, through a computerized central randomization system, into four groups (the combined, iAM-only, sertraline-only, and placebo groups). Participants will undergo a 12-week intervention with either 50 mg of sertraline or a placebo once a day and active/sham iAM treatment three times per week. The primary outcome is depression severity, assessed using the Hamilton Depression Scale-17. The secondary outcomes include self-rated depression severity, anxiety, and sleep quality. The primary and secondary outcomes will be measured at weeks 0, 4, 8, 12, and the 8th week posttreatment. Safety will be evaluated through liver and kidney function tests conducted before and after treatment and through monitoring of daily adverse events. An intent-to-treat principle will be followed for the outcome analyses.This trial will provide sufficient evidence to ascertain whether iAM is effective and safe for treating MDD and provides a suitable combination strategy for treating MDD.[www.chictr.org.cn], identifier [ChiCTR2100042841].

Sertraline

Depression

Moxibustion

10.3389/fmed.2022.761419

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Gray matter and cognitive alteration related to chronic obstructive pulmonary disease patients: combining ALE meta-analysis and MACM analysis

Brain Imaging and Behavior (2024)

Junquan Liang Qiaoyun Yu Limei Chen Zhongxian Li Yuchen Liu

Chronic obstructive pulmonary disease (COPD) is frequently comorbid with cognitive impairment, but it has not been paid enough attention, and its neuroanatomical characteristics have not been fully identified. Voxel-based morphometric (VBM) studies comparing gray matter (GM) abnormalities in COPD patients with healthy controls (HCs) were searched using 8 electronic databases from the inception to March 2023. Stereotactic data were extracted and tested for convergence and differences using the activation likelihood estimation (ALE) method. Moreover, based on the ALE results, a structural meta-analytic connectivity modeling (MACM) was conducted to explore the co-atrophy pattern in patients with COPD. Last, behavioral analysis was performed to assess the functional roles of the regions affected by COPD. In total, 11 studies on COPD with 949 participants were included. Voxel-based meta-analysis revealed significant GM abnormalities in the right postcentral gyrus (including inferior parietal lobule), left precentral gyrus, and left cingulate gyrus (including paracentral lobule) in patients with COPD compared with HCs. Further MACM analysis revealed a deeper co-atrophy pattern between the brain regions with abnormal GM structure and the insula in COPD patients. Behavioral analysis showed that the abnormal GM structure in the left cingulate gyrus (including paracentral lobule) was strongly associated with cognitive function, especially executive function. COPD comorbid with cognitive impairment has a specific neurostructural basis of GM structural abnormalities, which may also involve a deeper co-atrophy pattern between the insula. These findings enhance our understanding of the underlying neuropathogenesis and suggest potential imaging markers for cognitive impairment in COPD patients. PROSPERO registration number: CRD42022298722.

10.1007/s11682-024-00946-y

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Acupuncture for generalized anxiety disorder: a study protocol for a randomized controlled trial

Brazilian Journal of Medical and Biological Research (2024)

Xiayun Zhou Guo-Ao Shi Rui-Ming Chen Lingsan Hu Z Li

During the COVID-19 outbreak, there was a sharp increase in generalized anxiety disorder (GAD). Acupuncture therapy has the advantages of accurate clinical efficacy, safety and reliability, few adverse reactions, and no dependence, and is gradually becoming one of the emerging therapies for treating GAD. We present a study protocol for a randomized clinical trial with the aim of exploring the mechanism of brain plasticity in patients with GAD and evaluate the effectiveness and reliability of acupuncture treatment. Transcranial magnetic stimulation (TMS) will be used to assess cortical excitability in GAD patients and healthy people. Sixty-six GAD patients meeting the inclusion criteria will be randomly divided into two groups: TA group, (treatment with acupuncture and basic western medicine treatment) and SA group (sham acupuncture and basic western medicine treatment). Twenty healthy people will be recruited as the control group (HC). The parameters that will be evaluated are amplitude of motor evoked potentials (MEPs), cortical resting period (CSP), resting motor threshold (RMT), and Hamilton Anxiety Scale (HAMA) score. Secondary results will include blood analysis of γ-aminobutyric acid (GABA), glutamate (Glu), glutamine (Gln), serotonin (5-HT), and brain-derived nerve growth factor (BDNF). Outcomes will be assessed at baseline and after the intervention (week 8). This study protocol is the first clinical trial designed to detect differences in cerebral cortical excitability between healthy subjects and patients with GAD, and the comparison of clinical efficacy and reliability before and after acupuncture intervention is also one of the main contents of the protocol. We hope to find a suitable non-pharmacological alternative treatment for patients with GAD.

10.1590/1414-431x2024e13389

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The Role of Acupuncture in Hormonal Shock-Induced Cognitive-Related Symptoms in Perimenopausal Depression: A Randomized Clinical Controlled Trial

Frontiers in Psychiatry (2022)

Jun-He Zhou Delong Zhang Baile Ning Xiaojuan Xue Lin Zhao

Introduction: Perimenopausal depression is predominantly caused by hormone shock, but the underlying physical and psychological factors are still unclear. Objectives: To explore the constituent components of perimenopausal depression by dynamically depicting its influencing factors and interactive pathways from the perspective of embodied cognition. Methods: This is a randomized clinical controlled trial. In this study, electroacupuncture was compared with escitalopram. A total of 242 participants with mild to moderate perimenopausal depression were enrolled from 6 hospitals in China. Each participant had a 12-week intervention and a 12-week follow-up period. The primary outcome of this study is the Hamilton Depression Rating Scale (HAMD-17), and the secondary outcome is the menopause-specific quality of life scale (MENQOL), serum Follicle-stimulating hormone (FSH), luteinizing hormone (LH), and estrogen (E 2 ) levels. Results: The structural equation model suggested that hormone levels were not directly associated with HAMD-17 ( P = 0.852), while MENQOL was statistically correlated with HAMD-17 as an intermediary variable ( P < 0.001). Electroacupuncture gradually showed positive impacts on MENQOL and HAMD-17 during the follow-up period ( P < 0.05). Cognitive impairment is the dominant dimension of perimenopausal depression. Conclusions: Hormonal shock may affect clinical symptoms and poor quality of life to induce cognitive impairment leading perimenopausal depression, and this impact on cognition is embodied. Electroacupuncture has positive effect on perimenopausal depression and quality of life.

Depression

10.3389/fpsyt.2021.772523

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Citations (3)

Gray Matter and Cognitive Alteration Related to Chronic Obstructive Pulmonary Disease Patients: Combining ALE Meta-analysis and MACM Analysis

Research Square (Research Square) (2023)

Junquan Liang Qiaoyun Yu Limei Chen Zhongxian Li Yuchen Liu

Abstract Background: Chronic obstructive pulmonary disease (COPD) is frequently comorbid with cognitive impairment, but it has not been paid enough attention, and its neuroanatomical characteristics have not been fully identified. Methods: Voxel-based morphometric (VBM) studies comparing gray matter (GM) abnormalities in COPD patients with healthy controls (HCs) were searched using 8 electronic databases from the inception to March 2023. Stereotactic data were extracted and tested for convergence and differences using the activation likelihood estimation (ALE) method. Moreover, based on the ALE results, a structural meta-analytic connectivity modeling (MACM) was conducted to explore the co-atrophy pattern in patients with COPD. Last, behavioral analysis was performed to assess the functional roles of the regions affected by COPD. Results: In total, 11 studies on COPD with 949 participants were included. Voxel-based meta-analysis revealed significant GM abnormalities in the right postcentral gyrus (including inferior parietal lobule), left precentral gyrus, and left cingulate gyrus (including paracentral lobule) in patients with COPD compared with HCs. Further MACM analysis revealed a deeper co-atrophy pattern between the brain regions with abnormal GM structure and the insula in COPD patients. Behavioral analysis showed that the abnormal GM structure in the left cingulate gyrus (including paracentral lobule) was strongly associated with cognitive function, especially executive function. Conclusions: COPD comorbid with cognitive impairment has a specific neurostructural basis of GM structural abnormalities, which may also involve a deeper co-atrophy pattern between the insula. These findings enhance our understanding of the underlying neuropathogenesis and suggest potential imaging markers for cognitive impairment in COPD patients. PROSPERO registration number: CRD42022298722.

Inferior parietal lobule

Precentral gyrus

Voxel-based morphometry

Postcentral gyrus

Middle frontal gyrus

10.21203/rs.3.rs-3708858/v1

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Fire acupuncture for plaque psoriasis case series

Medicine (2024)

Rui-Ming Chen Guo-Ao Shi Yong-Qin Xiong Zhongxian Li Xiang Ji

To investigate the clinical efficacy of fire acupuncture (FA) on plaque psoriasis (PP), exploring its suitable syndrome types, in order to achieve better therapeutic effects, accelerate the possibility of psoriasis skin lesion recovery, and provide assistance for clinical treatment.

10.1097/md.0000000000037848

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Gray matter abnormalities in patients with major depressive disorder and social anxiety disorder: a voxel-based meta-analysis

Brain Imaging and Behavior (2023)

Junquan Liang Qiaoyun Yu Yuchen Liu Yidan Qiu Rundong Tang

Abstract Background Major depressive and social anxiety disorders have a high comorbidity rate and similar cognitive patterns. However, their unique and shared neuroanatomical characteristics have not been fully identified. Methods Voxel-based morphometric studies comparing gray matter volume between patients with major depressive disorder/social anxiety disorder and healthy controls were searched using 4 electronic databases from the inception to March 2022. Stereotactic data were extracted and subsequently tested for convergence and differences using activation likelihood estimation. In addition, based on the result of the meta-analysis, behavioral analysis was performed to assess the functional roles of the regions affected by major depressive disorder and/or social anxiety disorder. Results In total, 34 studies on major depressive disorder with 2873 participants, and 10 studies on social anxiety disorder with 1004 subjects were included. Gray matter volume conjunction analysis showed that the right parahippocampal gyrus region, especially the amygdala, was smaller in patients compared to healthy controls. The contrast analysis of major depressive disorder and social anxiety disorder revealed lower gray matter volume in the right lentiform nucleus and medial frontal gyrus in social anxiety disorder and lower gray matter volume in the left parahippocampal gyrus in major depressive disorder. Behavioral analysis showed that regions with lower gray matter volume in social anxiety disorder are strongly associated with negative emotional processes. Conclusions The shared and unique patterns of gray matter volume abnormalities in patients with major depressive and social anxiety disorder may be linked to the underlying neuropathogenesis of these mental illnesses and provide potential biomarkers. PROSPERO registration number: CRD42021277546.

Voxel-based morphometry

Parahippocampal gyrus

10.1007/s11682-023-00797-z

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Intradermal Thumbtack Needle Alleviates Depressive Symptoms and Resets Executive Control System Function in Young Patients With Subthreshold Depression: A Study Protocol of a Randomized, Controlled, and Single-Blind Trial {1}

Research Square (Research Square) (2021)

Shenyi Huang Baile Ning Luda Yan Jiating Lin Wenbin Fu

Abstract Background: Subthreshold depression is the prodromal stage of a depressive episode, which is characterized by depressive symptoms but fails to meet the diagnostic criteria for depression. At present, there is no recognized therapy for subthreshold depression worldwide. Studies have also shown that acupoint stimulation can significantly decrease depressive symptoms by modulating different executive control systems, such as reward circuits and motivational circuits. In this proposed study, our objective is to evaluate the efficacy of intradermal thumbtack needle therapy, a continuous and effective acupoint stimulation therapy, on subthreshold depression and generate hypotheses on the mechanism by which this therapy resets executive control system function in young patients with subthreshold depression. Method: In this randomized controlled trial, all eligible participants are diagnosed with subthreshold depression. Participants are randomly assigned to two groups at a ratio of 1:1 and receive either intradermal thumbtack needle or sham intradermal thumbtack needle therapy. The primary outcome is self-reported depression severity on the 9-item Patient Health Questionnaire (PHQ-9) from baseline to 6 weeks. The secondary outcomes include the Short Form Survey (SF-12) and the Generalized Anxiety Disorder Assessment (GAD-7) complementarity. Two psychological paradigms, the Attention Network Test (ANT) and the Psychomotor Vigilance Task (PVT), and functional magnetic resonance imaging (fMRI) will be used to evaluate the mechanism. These two psychological paradigms will explain the mechanism from the perspective of executive control in psychology, and fMRI will reflect the change in functional reset of the executive control system from an imaging point of view. The results are obtained at the start of treatment andthe end of treatment. The entire duration of the study will be approximately 12 months. Discussion: This study is designed to evaluate the efficacy of intradermal thumbtack needle on StD patients. Additionally, mechanisms by which this therapy resets executive control system function will be studied Trial registration: NCT04319562. [ClinicalTrials.gov] [registered before start of inclusion; 24 March 2020] {2a and 2b}

Subthreshold conduction

Depression

10.21203/rs.3.rs-76108/v1

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