Guiquan Zhang

South China Agricultural University

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Co-Authors

Haitao Zhu

South China Agricultural University

Ruizhen Zeng

South China Agricultural University

Guifu Liu

South China Agricultural University

Shaokui Wang

South China Agricultural University

Xin Luan

Shanghai University of Traditional Chinese Medicine

Xuelin Fu

South China Agricultural University

Zemin Zhang

South China Agricultural University

Ziqiang Liu

South China Agricultural University

Suhong Bu

South China Agricultural University

Weifeng Yang

South China Agricultural University

Cooperative Institutions

South China Agricultural University

186

Chinese Academy of Sciences

114

Rice Research Institute

Ministry of Agriculture and Rural Affairs

State Key Laboratory For Conservation and Utilization of Subtropical Agro-Bioresources

Guangdong Academy of Agricultural Sciences

South China University of Technology

University of Chinese Academy of Sciences

Key Laboratory of Guangdong Province

Chinese Academy of Agricultural Sciences

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A quantitative assessment of the efficacy of an environmental enrichment programme for giant pandas

Animal Behaviour (2001)

Ronald R. Swaisgood Angela M. White Xiaoping Zhou Hemin Zhang Guiquan Zhang

Ailuropoda melanoleuca

Environmental Enrichment

PANDAS

Neophobia

10.1006/anbe.2000.1610

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Citations (120)

A Near-Infrared II Luminogen with a Photothermal Effect toward Tumor Drug Resistance Reversal

ACS Applied Materials & Interfaces (2024)

Kaihong Du Guiquan Zhang Dong He Zheng Chen Shanyang He

Multidrug resistance of tumor cells has greatly limited the chemotherapy effect. The development of reliable strategies to deal with tumor multidrug resistance is highly desirable for tumor therapy. In this work, a near-infrared II (NIR II) luminogen was rationally designed and prepared, which could act as a photothermal reagent to reverse the drug resistance of tumor cells by reducing the related protein expression, achieving a high inhibition efficiency with the synergistic effect of chemotherapeutic drugs. By the selection of a strong electron-withdrawing unit, the emission peak of the luminogen could reach 973 nm. Moreover, this luminogen shows outstanding photothermal conversion ability and improved thermal stability compared to ICG. Notably, after the photothermal treatment of drug-resistant tumor cells by the NIR II luminogen, the antitumor efficiency of chemotherapeutic drugs, including paclitaxel, cis-platinum, and doxorubicin, was significantly enhanced. The mechanism exploration revealed that drug resistance-related proteins were remarkably reduced, making the cells more sensitive toward drugs. Thus, this strategy demonstrated a promising and reliable approach to reverse the drug resistance of tumor cells for efficient tumor inhibition in the clinic.

10.1021/acsami.4c14811

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Karyotypes of four {\sl Cymbidium sinense} cultivars in Guangdong

Redai yaredai zhiwu xuebao (2005)

Lü Fubing Genfa Zhu Biqing Wang Guiquan Zhang

The karyotypes of four Cymbidium sinense cultivars were studied. Somatic chromosome numbers of cultivars 'Qijianheimo'and 'Qijianbaimo'are 2n=40 (diploid), the karyotype formulas being 2n=2x=40=30m+10sm and 2n=2x=40=2M+36m+2st, respectively. However, the chromosome number of cultivars 'Jinzui' and 'Yinbian' are 2n=41 and are aneuploid. The chromosome structures of all the four cultivars mainly consist of metacentric chromosomes. According to Stebbins'classification of karyotypic asymmetry, the karyotype of cv. 'Yinbian' is of 1B type, and that the other three of 2B type.

Chromosome number

Cymbidium

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A Kind of Method Which Makes Use of Blast Nurseries to Test the Resistance of SSSL and the Preliminary Analysis of the Test Result

Journal of Huizhou University (2007)

Guiquan Zhang

The research built up a kind of method which made use of the blast nurseries to test the resistance of SSSLs which the substi- tuted segment coverd the whole rice genome.Fist step,197 SSSLS had the obvious resistent differrence with Huajingxian,74 were chosen.This SSSL will be used for the rice breeding and the research of blast resistent gene.

Fist

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Substitution mapping of the major quantitative trait loci controlling stigma exsertion rate from Oryza glumaepatula

Research Square (Research Square) (2020)

Quanya Tan Tuo Zou Mingmin Zheng Yuerong Ni Xin Luan

Abstract Background: Stigma exsertion rate (SER) is a key determinant for outcrossing ability of male sterility lines (MSLs) in hybrid rice seed production. Outcrossing ability in cultivated rice varieties has diminished during the process of domestication, while wild Oryza species keep strong outcrossing ability. Here, we detected the quantitative trait loci (QTLs) controlling SER using a set of single-segment substitution lines (SSSLs) derived from O. glumaepatula , a wild Oryza species. Results: Seven QTLs for SER, qSER-1a , qSER-1b , qSER-3a , qSER-3b , qSER-5 , qSER-9 and qSER-10 , were located on 5 chromosomes. qSER-1a and qSER-1b were located on chromosome 1. qSER-3a and qSER-3b were mapped on chromosome 3, and qSER-3b was further located at an interval of 931.0kb by secondary substitution mapping. qSER-5 , qSER-9 and qSER-10 were identified on chromosomes 5, 9 and 10, respectively, and qSER-9 was delimited to a region of 608.2kb by secondary substitution mapping. The additive effects of the 7 QTLs ranged from 10.6% to 14.8%, and the additive contribution variances explained by each of the QTLs were from 36.3% to 50.6%, which were higher than those of most loci for SER reported previously. Conclusions: qSER-1a and qSER-1b were novel loci for SER on chromosome 1. All of the 7 QTLs had major effects on SER. The major QTLs of SER will help to develop MSLs with strong outcrossing ability.

Outcrossing

10.21203/rs.3.rs-21523/v1

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Citations (3)

Analysis of coefficient of parentage among major commercial inbred indica rice cultivars in South China.

Journal of the South China Agricultural University (2012)

Chuanguang Liu Xinqiao Zhou Dagang Chen Zhou HanQin Feng DaoJi

Coefficient of parentage among crop cultivars is one of major methods for evaluating genetic relationship and genetic diversity among crop cultivars.Coefficient of parentage was analyzed among the inbred indica rice cultivars which were released in different eras in South China.The result showed that the genetic diversity among the cultivars released in the past 50 years changed as a W shape.Three summits happened in pre-1957,1970-1979,and 2000-2008,and two lowest happened in 1957-1969 and 1980-1989.The result of cultivars clustering analysis based on coefficient of parentage indicated the genetic relationships among the inbred indica rice cultivars and the characteristics of the cultivars evolution in South China.It was coincident with the characteristic of the cultivars improvement based on a few core parents in different eras.These indicated that the genetic diversity in the inbred indica rice cultivars changed as coefficient of parentage among inbred indica cultivars in South China and the genetic diversity had not increased or fall continuously in the past 50 years,but fluctuated in a limited range.

Inbred strain

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Research Development of Preparation Technology for Nano-CeO_2

Cailiao daobao (2009)

Guiquan Zhang Yankun Cheng

Particle (ecology)

Liquid phase

Deposition

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Lab-in-Cell: A Covalent Photosensitizer Reverses Hypoxia and Evokes Ferroptosis and Pyroptosis for Enhanced Anti-Tumor Immunity.

PubMed (2025)

Bingnan Wang Guiquan Zhang Zheng Chen Hanchen Shen Chunyang Li

Photodynamic immunotherapy presents a non-invasive strategy characterized by spatiotemporal control and minimal side effects to induce immunogenic cell death (ICD). This approach significantly enhances the release of tumor-associated antigens and damage-associated molecular patterns, thereby improving cancer immunotherapy outcomes. However, hypoxia and antioxidant defenses at tumor sites considerably diminish the efficacy of photodynamic immunotherapy. In this work, a covalent warhead, alkyneamide, is introduced into an AIE photosensitizer to develop a novel covalent photosensitizer, MBTP-PA, which targets redox systems and facilitates ferroptosis- and pyroptosis-mediated photodynamic immunotherapy by thiol-yne click reactions. The covalent photosensitizer interacts with intracellular thiol compounds such as cysteine and glutathione, disrupting the intracellular antioxidant system and alleviating hypoxia. This results in enhanced photodynamic therapy (PDT) efficacy compared to the non-covalent photosensitizer MBTP-A. Furthermore, in conjunction with PDT, this reaction therapy can activate ICD through ferroptosis and pyroptosis, thereby enhancing anti-tumor immunity. Notably, in vivo injection of MBTP-PA nanoparticles at the tumor site led to the elimination of primary tumors, inhibiting distal tumors and exhibiting minimal side effects. Therefore, this work not only integrates the thiol-yne click reactions into cellular systems, significantly enhancing the efficacy of photodynamic immunotherapy but also paves the way for developing novel photosensitizers.

Pyroptosis

Hypoxia

10.1002/adma.202415673

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Genetic characterization of the chromosome single-segment substitution lines of O. glumaepatula and O. barthii and identification of QTLs for yield-related traits

Molecular Breeding (2019)

Hanwei Zhao Lingling Sun Tianyi Xiong Zhangqiang Wang Yu Liao

10.1007/s11032-019-0960-0

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Citations (27)

Additive Effects and Epistasis Effects of QTL for Plant Height and Its Components Using Single Segment Substitution Lines (SSSLs) in Rice