Evelina G. Ferrer

Universidad Nacional de La Plata

Author Statistics

Papers

Citation

H-Index

i-10 index

Research Trends

Author Order

Document Type

Co-Authors

Patricia A.M. Williams

Universidad Nacional de La Plata

129

Oscar E. Piro

Universidad Nacional de La Plata

Luciana G. Naso

Universidad Nacional de La Plata

Enrique J. Baran

Universidad Nacional de La Plata

E.E. Castellano

Universidade de São Paulo

Luís Lezama

University of the Basque Country

Juan J. Martínez Medina

Hospital Luis Vernaza

Gustavo A. Echeverría

Universidad Nacional de La Plata

P.A.M. Williams

María S. Islas

Consejo Nacional de Investigaciones Científicas y Técnicas

Cooperative Institutions

Consejo Nacional de Investigaciones Científicas y Técnicas

Universidad Nacional de La Plata

Centro Científico Tecnológico - La Plata

Royal Society of Chemistry

Centre National pour la Recherche Scientifique et Technique (CNRST)

Instituto de Física La Plata

Centro de Investigación y Desarrollo en Criotecnología de Alimentos

University of the Basque Country

National University of Tucumán

Centro Científico Tecnológico - Tucumán

Author Statistics

Papers

Citation

H-Index

i-10 index

Research Field

Spectroscopic and thermal behaviour of complex compounds useful for magnesium supplementation

Acta farmacéutica bonaerense (1999)

Claudia C. Wagner Evelina G. Ferrer Enrique J. Baran

We present the synthesis of three Mg(I1) complexes potentially useful for magnesium supplementation in human and veterinary medicine: magnesium chloro-aspartate, Mg(C4H604N)C1.3Hz0; magnesium citrate, ~g(H20)6][MgC6H507(H20)]25Hz0, and magnesium orotate, [Mg(C5H304N2)2].8H20. These compounds were characterized by IR and Raman spectroscopy and their thermal behaviour was investigated by means of thermogravimetric measurements and differential tliermal analysis, working in oxygen atmosphere. RESUMEN. Comportamiento Espectroscopico y Termico de Compuestos Complejos Utiles para la Suplementacioii de Magiiesio. Se presenta la sintesis de tres complejos de Mg(I1) potencialniente utiles para la suplementacioii de este elemento en medicina Iiumaiia y veterinaria: cloro-aspartato de magnesio, Mg(C4H6O4N)Cl.3H2O; citrato de magiiesio, [Mg(H20)6][MgC6H507(H20)]2.5Hfl; y orotato de magnesio, [Mg(C5H304N2)2].8H20. Estos compuestos se caracterizaron a traves de sus espectros de IR y Raman y su comportamiento termico fue investigado por terinograviiiietria y analisis termico diferencial, trabajando en corriente de oxigeno.

Source

Cite

Citations (2)

Antioxidant and Anticancer Activities and Protein Interaction of the Oxidovanadium(IV) Naringin Complex

Inorganics (2022)

Gonzalo Restrepo-Guerrero Helen Goitia Luciana G. Naso Marilín Rey Pablo J. González

The complex of oxidovanadium(IV) with naringin (Narg) [VO(Narg)2] 8H2O (VONarg) was prepared according to the literature improving the synthetic procedure and physicochemical characterization. In addition, biological activities (cytotoxic, antioxidant, and BSA interaction) were determined. The metal coordinated through the 5-hydroxy and 4-carbonyl groups of rings A and C of naringin, respectively. The antioxidant activity of VONarg, determined in vitro, was higher than those of the flavonoid against superoxide and peroxyl reactive oxygen species (ROS) and DPPH radical. The cytotoxic properties were determined by a MTT assay on adenocarcinoma human alveolar basal epithelial cells (A549). VONarg exerted a 20% decrease in cancer cells viability at 24 h incubation, while naringin and oxidovanadium(IV) cation did not show cytotoxicity. Measurements with the normal HEK293 cell line showed that the inhibitory action of the complex is selective. VONarg generated intracellular reactive oxygen species (ROS), depletion of reduced glutathione and depolarization of mitochondrial membrane potential, typical for apoptotic pathway, producing cell death by oxidative stress mechanism. Moreover, naringin interacted with bovine serum albumin (BSA) through hydrophobic interactions in a spontaneous process, and VONarg showed greater affinity for the protein but can still be transported and delivered by it (Ka 104 L·mol−1 order).

Naringin

Bovine serum albumin

10.3390/inorganics10010013

Cite

Citations (8)

ESTUDIO DE FÁRMACOS MODIFICADOS POR COMPLEJACIÓN CON BIOMETALES. DETERMINACIÓN DE SUS PROPIEDADES BIOLÓGICAS

Investigación Joven (2020)

Agustin B. Actis Dato Patricia A.M. Williams Evelina G. Ferrer

Source

Cite

Citations (0)

Phosphatase Alkaline Inhibition and Antithyroid Activity of Acetylacetone Sulfonamide Derived Schiff Base. In Vitro and In Silico Studies

ChemistrySelect (2024)

Gisela M. Gaddi Janetsi Y. Caro‐Ramírez Yamila B. Antonena Carlos A. Franca Leandro Martínez Heredia

Abstract The sulfonamide‐derived compounds have demonstrated various pharmaceutical properties. However, the exploration of certain properties, such as phosphatase inhibition and anti‐thyroid activities, has been limited in the existing literature. The present study aimed to investigate these specific activities for the Schiff base (Z)‐4‐(4‐oxopent‐2‐en‐2‐ylamino)benzenesulfonamide. The compound underwent thorough physicochemical characterization, including FTIR, Raman, and UV‐Vis spectroscopy, along with theoretical DFT calculations. It exhibited inhibitory activity against intestinal alkaline phosphatase, showing an IC 50 value of 37.0±1.0 μM, with kinetic studies indicating a mixed mode of inhibition. Additional insights into the inhibition process were gained through fluorescence spectroscopy and molecular docking studies. The potential anti‐thyroid activity was explored through charge‐transfer studies with iodine, revealing a strong interaction ( K c =2.16±0.05×10 4 M −1 ), suggesting a role in reducing the iodination process of triiodothyronine (T3) and thyroxine (T4). Moreover, the compound showed strong, spontaneous, and reversible binding to albumin, indicating potential pharmaceutical relevance. ADME properties were also calculated, confirming favorable drug‐likeness. This study provides valuable insights into the multifaceted pharmaceutical properties of the investigated sulfonamide‐derived compound, encouraging further exploration of its therapeutic potential.

Acetylacetone

Sulfonamide

Sulfanilamide

10.1002/slct.202401342

Cite

Citations (0)

Comportamiento térmico de la Auranofina

Acta Farmacéutica Bonaerense (1999)

Enrique J. Baran Evelina G. Ferrer Gloria E. Tobón Zapata

Source

Cite

Citations (0)

Carbidopa and ZnCarbidopa Induce Reductive Stress in MDA‐MB‐231 Cells

ChemPlusChem (2024)

Agustin B. Actis Dato Luciana G. Naso Valeria R. Martínez Evelina G. Ferrer Patricia A.M. Williams

The redox imbalance, caused by depletion or generation of reactive oxygen species (ROS), is a key mechanism by which metal complexes exert anticancer effects. Carbidopa has shown the ability to inhibit the MDA-MB-231 cell line, a highly aggressive triple-negative human breast adenocarcinoma, by inducing reductive stress. The metal complex of carbidopa with zinc (ZnCarbi) was designed to modify carbidopa's structure and exhibited increased cytotoxicity against MDA-MB-231 cells. Interestingly, ZnCarbi selectively targets certain cancer cells, showing no impact on the viability of normal HEK293 (human embryonic kidney) cells or other cancer cell lines like A549 (human lung adenocarcinoma), LM3 (murine breast adenocarcinoma), or HCT116 (human colon cancer). Treatment with carbidopa and ZnCarbi induces reductive stress, decreases ROS levels, increases the GSH/GSSG ratio, and protects cells from H2O2-induced death. Both compounds also cause mitochondrial damage, leading to cell death, and exhibit antimetastatic effects by inhibiting cell migration and invasion of MDA-MB-231 cells. Interaction studies with bovine serum albumin showed moderate binding through hydrophobic association. Overall, ZnCarbi demonstrates enhanced anticancer properties compared to carbidopa alone, highlighting its potential as an anticancer and antimetastatic compound.

10.1002/cplu.202400596

Cite

Citations (0)

Vanadium Compounds as Biocatalyst Models

Biological Trace Element Research (2019)

Juliana E. Parente Patricia A.M. Williams Evelina G. Ferrer

Pyrogallol

Biocatalysis

Michaelis–Menten kinetics

10.1007/s12011-019-01874-5

Cite

Citations (1)

CCDC 693203: Experimental Crystal Structure Determination

The Cambridge Structural Database (2012)

Evelina G. Ferrer N. Baeza Luciana Naso E.E. Castellano Oscar E. Piro

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.

10.5517/ccr8bdq

Cite

Citations (0)

Insights into the mechanisms underlying the antitumor activity of an oxidovanadium(IV) compound with the antioxidant naringenin. Albumin binding studies

Journal of Inorganic Biochemistry (2015)

María S. Islas Luciana G. Naso Luís Lezama María Valcárcel Clarisa Salado

Bovine serum albumin

10.1016/j.jinorgbio.2015.04.011

Cite

Citations (42)

CCDC 718868: Experimental Crystal Structure Determination

The Cambridge Structural Database (2011)

P.A.M. Williams Luciana Naso Gustavo A. Echeverría Evelina G. Ferrer

10.5517/ccs4197

Cite

Citations (0)