Dominique Thierry

French Corrosion Institute

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A. Nazarov

French Corrosion Institute

Tomáš Prošek

University of Chemistry and Technology, Prague

Dan Persson

RISE Research Institutes of Sweden

N. LeBozec

French Corrosion Institute

Alain Chapel

Institut de Radioprotection et de Sûreté Nucléaire

Nicolas Larché

French Corrosion Institute

Stéphane Rioual

Université de Bretagne Occidentale

B. Lescop

Université de Bretagne Occidentale

Erwan Diler

French Corrosion Institute

Flavien Vucko

French Corrosion Institute

Cooperative Institutions

Centre National de la Recherche Scientifique

149

Inserm

108

Sorbonne Université

French Corrosion Institute

Université Paris Cité

Assistance Publique – Hôpitaux de Paris

Commissariat à l'Énergie Atomique et aux Énergies Alternatives

Institut de Radioprotection et de Sûreté Nucléaire

Hôpital Saint-Antoine

Institut Pasteur

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177

International Journal of Radiation Oncology*Biology*Physics (2006)

Morad Bensidhoum Stéphanie Gobin Alain Chapel Pascale Le Minter Gilles Waksman

10.1016/j.ijrobp.2006.07.209

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Influence of Carbon Dioxide on the Atmospheric Corrosion of Zinc-Aluminium and Zinc-Aluminium-Magnesium Coated Steel

Meeting abstracts/Meeting abstracts (Electrochemical Society. CD-ROM) (2018)

Nathalie Le Bozec Dominique Thierry Anne Le Gac Dan Persson

The superior corrosion resistance of hot dip galvanized steel (HDG) alloyed with addition of Al and Mg compared to conventional zinc coating has been shown in numerous atmospheric conditions including accelerated tests and natural exposures. Despite significant work in understanding the mechanisms of corrosion of Zn-Al-Mg coatings, there are still gaps of knowledge such as, on the exact interactions between the complex microstructure of theses coatings and their corrosion properties. A large European (RFCS) project namely MicroCorr has been initiated in 2015 with the aims of better understanding these aspects. On task was to examine the effect of surface pH and contaminations as well as relative humidity and temperature on the corrosion performance of well-defined microstructures of alloyed zinc coatings with Al and Mg. The present study focuses on the effect of carbon dioxide depletion on the atmospheric corrosion stability of Zn alloyed coatings compared to conventional HDG (Zn-0.2Al) and Galfan (Zn-5Al). Zn-Al-Mg and Zn-55Al coatings produced with various microstructures differing in the grain size were investigated in low and ambient concentration of CO 2 with two levels of chloride concentration. In addition to mass loss data, the surface pH was measured using wide range pH indicator in agar-agar gel. The corrosion products were analyzed by FTIR spectroscopy and X-Ray diffraction. The corrosion of HDG and zinc alloyed coatings with low content of Al and Mg was significantly enhanced in low CO 2 conditions particularly at high chloride concentration and whatever the microstructure. This was connected to a high surface pH in the absence of CO 2 . Surprisingly, similar weight losses were measured for Zn-55Al coatings whatever the level of CO 2 and no increase of surface pH was observed even in depleted CO 2 conditions. However, important localised corrosion was observed for this coating

Carbon steel

Conversion coating

10.1149/ma2018-02/12/628

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Long term bone marrow culture in metastatic neuroblastoma

European Journal of Cancer and Clinical Oncology (1989)

Dominique Thierry Pierre Validire Madeleine F. Hardy H Magdelénat Jean Michel Zucker

10.1016/0277-5379(89)90003-5

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Les Chrysoperla Steinmann de Roumanie (Neuroptera: Chrysopidae)⁽¹⁾

Annales de la Société entomologique de France (N S ) (1996)

M. Paulian M. Canard Dominique Thierry Roger Cloupeau

Chrysoperla carnea

10.1080/21686351.1996.12278870

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Citations (1)

Environmental Factors Affecting the Corrosion Resistance of Zinc Coated Steel Sheets For Automotive and Residential Applications

材料とプロセス : 日本鉄鋼協会講演論文集 = Current advances in materials and processes : report of the ISIJ meeting (2002)

Dominique Thierry

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In vivo gene targeting of IL-3 into immature hematopoietic cells through CD117 receptor mediated antibody gene delivery.

Genetic Vaccines and Therapy (2004)

Alain Chapel Olivier Déas Morad Bensidhoum Sabine François Moubarak Mouiseddine

Targeted gene transfection remains a crucial issue to permit the real development of genetic therapy. As such, in vivo targeted transfection of specific subsets of hematopoietic stem cells might help to sustain hematopoietic recovery from bone marrow aplasia by providing local production of growth factors.Balb/C mice were injected intravenously, with an anti-mouse c-kit (CD117) monoclonal antibody chemically coupled to a human IL-3 gene-containing plasmid DNA. Mice were sacrificed for tissue analyses at various days after injection of the conjugates.By ELISA, the production of human IL-3 was evidenced in the sera of animals 5 days after treatment. Cytofluorometric analysis after in vivo transfection of a reporter gene eGFP demonstrated transfection of CD117+/Sca1+ hematopoietic immature cells. By PCR analysis of genomic DNA and RNA using primer specific pIL3 sequences, presence and expression of the human IL-3-transgene were detected in the bone marrow up to 10 days in transfected mice but not in control animals.These data clearly indicate that antibody-mediated endocytosis gene transfer allows the expression of the IL-3 transgene into hematopoietic immature cells, in vivo. While availability of marketed recombinant growth factors is restricted, this targeting strategy should permit delivery of therapeutic genes to tissues of interest through systemic delivery. In particular, the ability to specifically target growth factor expression into repopulating hematopoietic stem cells may create new opportunities for the treatment of primary or radiation-induced marrow failures.

10.1186/1479-0556-2-16

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Interleukine-8 Acts as a Strong Peripheral Blood Granulocyte-Recruiting Agent Rather Than as a Hematopoietic Progenitor Cell-Mobilizing Factor

Journal of Hematotherapy & Stem Cell Research (1999)

J. Vetillard Michel Drouet Thi My Anh Neildez‐Nguyen J.C. Mestries Jacques R.R. Mathieu

Intravenous infusion of Interleukine-8 has been shown to lead to a rapid mobilization of hematopoietic cells in mice and rhesus monkeys. We report in this study that the IL-8-mediated mobilizing effect results in low levels of circulating CD34+ cells, whereas a rapid and strong recruitment of mature granulocytes occurs. This would be of great interest for harvesting large numbers of functional granulocytes to fight infection in immunodepressed patients. We performed a kinetic study of the mobilization in a nonhuman primate model (Papio ursinus), mobilized with a single or double infusion of IL-8 with a dose range of 30-50 microg/kg of body weight. Blood was sampled every 15 min after the IL-8 infusion, and IL-8 plasma levels, complete blood counts, differential WBCC, colony-forming unit assays, and CD34+ cell evaluation assays were performed. At the same time, leukapheresis was performed on the anesthetized animal to collect either hematopoietic stem and progenitor cells (HSPC) or peripheral blood granulocytes (PBG) according to different collection settings. IL-8 induced a rapid increase of PBG (7-12-fold the basal values). The HSPC leukapheresis concentrate showed poor ex vivo expansion abilities. IL-8-mobilized peripheral blood polymorphonuclear cells showed normal oxidative, chemotactic, phagocytic, and adherence abilities. We suggest that IL-8-induced neutrophilia could be used as an allogeneic source of granulocytes for transfusion in neutropenic patients or in granulocyte dysfunction.

Leukapheresis

Neutrophilia

Hematopoietic growth factor

10.1089/152581699320126

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Fatigue Behavior of Super Duplex Stainless Steel Exposed in Natural Seawater Under Cathodic Protection

Frontiers in Materials (2022)

Flavien Vucko Geoffrey Ringot Dominique Thierry Nicolas Larché

Under operating conditions, alternated loading and fatigue are encountered, controlling the durability and safety of components and structures made of super duplex stainless steel (SDSS). In particular, the use of a cathodic protection (CP) system to protect the structure against corrosion can induce hydrogen charging of the SDSS. Thus, the aim of this study was to investigate the sensitivity of some industrial products made of SDSS 2507 (UNS S32750), without artificial thermal aging, under test conditions as close as possible to real environments. In situ fatigue tests under alternated 4-point bending conditions were conducted in natural seawater with and without CP. The fatigue behavior was evaluated as a function of environmental parameters, such as temperature, and material parameters, particularly the austenite spacing and microstructure around orbital welds by Tungsten Inert Gas (TIG) welding and stress concentrations, through the presence of surface defects. The fatigue life obtained in air or in seawater at the open circuit potential (OCP) was rather similar. Fatigue life enhancement was systematically observed under CP particularly in the range of low applied load, despite evidence of brittle failure on the fracture surfaces of samples tested under CP. The data suggest immunity of the SDSS to hydrogen embrittlement under the present experimental conditions of fatigue testing.

Corrosion Fatigue

Artificial seawater

Galvanic anode

Embrittlement

10.3389/fmats.2022.826189

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Improving corrosion stability of ZnAlMg by alloying for protection of car bodies

Surface and Coatings Technology (2016)

Tomáš Prošek A. Nazarov Frank Goodwin Jan Šerák Dominique Thierry

Galvanic corrosion

Galvanic cell