Xin‐Sheng Yao

Shenyang Pharmaceutical University

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Hao Gao

Jinan University

123

Yi Dai

Jinan University

Naili Wang

Chinese Academy of Medical Sciences & Peking Union Medical College

Guo‐Dong Chen

Jinan University

Yang Yu

Laboratoire de Chémo-biologie synthétique et thérapeutique

Dan Hu

Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University

Jinshan Tang

Jinan University

Zhihong Yao

Jinan University

Man‐Sau Wong

Hong Kong Polytechnic University

Feng Qiu

Tianjin University of Traditional Chinese Medicine

Cooperative Institutions

Jinan University

391

Chinese Academy of Sciences

264

Shenyang Pharmaceutical University

218

Chinese Academy of Medical Sciences & Peking Union Medical College

136

Sun Yat-sen University

122

University of Chinese Academy of Sciences

106

Peking University

Zhejiang University

Shanghai Jiao Tong University

Sichuan University

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Brasilamides A–D: Sesquiterpenoids from the Plant Endophytic Fungus Paraconiothyrium brasiliense

European Journal of Organic Chemistry (2010)

Ling Liu Hao Gao Xu‐Lin Chen Xiaoyue Cai Leilei Yang

Abstract New tricyclic sesquiterpenoids brasilamides A–D ( 1 – 4 ) and the known pinthunamide ( 5 ) have been isolated from cultures of the plant endophytic fungus Paraconiothyrium brasiliense Verkley. Their structures were elucidated primarily by NMR spectroscopy, and the structure of 1 was further confirmed by X‐ray crystallography. The absolute configuration of the C‐5 tertiary alcohol in 2 was assigned by analogy to 1 and confirmed by observing the circular dichroism of in situ generated [Rh 2 (OCOCF 3 ) 4 ] complex. Compounds 2 – 4 showed modest inhibitory effects on HIV‐1 replication in C8166 cells. Compounds 1 and 2 possess an unprecedented4‐oxatricyclo‐[3.3.1.0 2,7 ]nonane skeleton.

Absolute Configuration

Nonane

10.1002/ejoc.201000284

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Citations (52)

Metabolites profile of Gualou Xiebai Baijiu decoction (a classical traditional Chinese medicine prescription) in rats by ultra-performance liquid chromatography coupled with quadrupole time-of-flight tandem mass spectrometry

Journal of Chromatography B (2018)

Pei Lin Zifei Qin Zhihong Yao Li Wang Weiyang Zhang

Decoction

Metabolic pathway

Primary metabolite

Hydroxylation

10.1016/j.jchromb.2018.04.001

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Citations (42)

Correction: Hong, K. et al. Actinomycetes for Marine Drug Discovery Isolated from Mangrove Soils and Plants in China. Mar. Drugs 2009, 7, 24–44

Marine Drugs (2009)

Kui Hong Anhui Gao Qingyi Xie Hao Gao Zhuang Ling

We found an error in our paper published in Marine Drugs [1]. [...]

10.3390/md7040495

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Citations (6)

金振口服液HPLC-UVD-ELSD特征指纹图谱及13个成分同时定量的整体质量控制研究

中草药 (2020)

王团结李海波 Haibo Li Tuanjie Wang Yang Qun Liu Ling-xian

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Goji berry-derived phenylpropionyl phenylethylamine derivatives protect against ethanol-induced hepatic damage

Deleted Journal (2024)

Zheng-Qun Zhou Zhaodi Che Jiancong Mai Rui Zhang Zhihui Luo

Goji berry is a famous edible and medicinal substance around the world. In this research, 15 phenylpropionyl phenylethylamine derivatives (1−15), including one new compound (1), were separated and identified from goji berry. All isolates were elucidated via extensive NMR spectral analyses and chemical techniques. Six known isolates were first obtained from Lycium genus. Six isolates were effectively split into double chromatographic peaks accompanied by the basically identical areas, indicating they belong to racemates. The ORAC experiment indicated that all isolates displayed a capacity of scavenging free radicals, and most of them exhibited higher ORAC values than EGCG. In ethanol/palmitic acid (PA)-established in vitro hepatocyte injury model, four phenylpropionyl phenylethylamine derivatives (1, 2, 9, and 15) significantly alleviated hepatocyte injury, among which compound 1 exerted the strongest protective activity. Notably, the hepatoprotective effect of compound 1 was further confirmed in ethanol-established liver damage mouse model, reflected by the reduction of lipid accumulation and the attenuation of pathological alteration. Combined with the in vitro results, the in vivo observations suggested that compound 1 suppressed cell apoptosis and the outburst of inflammation. Our findings provided first-hand evidence proving that goji berry-derived phenylpropionyl phenylethylamine derivatives hold a potential in treating alcoholic liver disease.

10.26599/fshw.2024.9250074

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Total Synthesis of Bulbophylol-B

Journal of Natural Products (2008)

Jinshun Lin Weige Zhang Nan Jiang Zeyu Niu Kai Bao

The first total synthesis of bulbophylol-B (1) has been achieved with the longest linear sequence of 12 steps and an overall yield of 17.9% via a new and practical approach to construct the dihydrodibenz[b,f]oxepin skeleton employing Wittig, selective reduction, and intramolecular Ullmann reactions as key steps.

Wittig reaction

Ullmann reaction

Sequence (biology)

10.1021/np800226n

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Citations (35)

Isolation,identification and activity determination on the anti-hypoxic components of Hypericum japonicum Thunb.

Xin‐Sheng Yao

Objective To study the anti-hypoxic components of the Herba Hyperici japonici(the whole plant of Hypericum japonicum Thunb.).Methods Compounds were isolated through various chromatography techniques.They were elucidated on the basis of physico-chemical properties and spectral methods and their anti-hypoxic activity were evaluated by PC12 cells.Results Five compounds were isolated from the Hypericum japonicum Thunb.and confirmed as 3-O-methylquercetin(1),protocatechuic acid(2),dihydronaphthol(3),dihydroquercetin(4),chlorogenic acid(5).Conclusions Among them,compounds 25 are isolated from the plant for the first time.All the compounds have some anti-hypoxic activities,wherein compound 2 exhibits very strong anti-hypoxic activity.

Protocatechuic acid

Chlorogenic Acid

Hypericum

Isolation

scopoletin

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Citations (1)

HPLC Fingerprint of Xianling Gubao Capsule,a TCM Prescription

Xin‐Sheng Yao

OBJECTIVE To establish the HPLC fingerprint of Xianling Gubao capsule(XLGB),a traditional Chinese medicine prescription in market coupled with similarity assay for the quality control of its products.METHODS The separation was developed on a C18 column(4.6 mm×250 mm,5 μm) by gradient elution with acetonitrile-water(both containing 0.1%(V/V) formic acid) as the mobile phase,flow rate at 0.80 mL·min-1,detection wavelength at 270 nm and column temperature at 35 ℃.An HPLC fingerprint of XLGB was set up and the quality of 28 batches of XLGB was evaluated by similarity assay.Furthermore,the main characteristic peaks in HPLC fingerprint of XLGB were identified by comparing the retention time with those of chemical reference substances and were assigned preliminarily to the individual herbs.RESULTS The established HPLC fingerprint of XLGB was specific,precise,reproducible and stable.The similarity of 28 batches of XLGB was about 0.952 to 0.995.Twenty-seven main characteristic peaks from six herbs of XLGB were chemically identified,which occupied 70% peak area of all the main peaks.CONCLUSION The established HPLC fingerprint with chemically identified main characteristic peaks represented the profile of XLGB and can be used for quality evaluation of its products.The above work can provide the experimental basis to improve overall quality control of XLGB.

Gradient elution

Capsule

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New furostanol saponins from the bulbs of Allium macrostemon Bunge and their cytotoxic activity.

PubMed (2007)

Haifeng Chen Guanghui Wang Naili Wang Mengsu Yang Zhao Wang

Four new furostanol saponins, named as macrostemonoside O, macrostemonoside P, macrostemonoside Q and macrostemonoside R, along with five known compounds, were isolated from the dried bulbs of Allium macrostemon Bunge. The structures of these new compounds were established by the spectral data elucidation (IR, ESIMS, 1D and 2D NMR) as 26-O-beta-D-glucopyranosyl-22-hydroxyl-5beta-furost-25 (27)-ene-3beta, 26-diol-3-O-beta-D-glucopyranosyl (1-->2)-beta-D-galactopyranoside (macrostemonoside O), (25R)-26-O-beta-D-glucopyranosyl-22-hydroxyl-5beta-furost-1beta, 3beta, 26-triol-3- O-beta-D-glucopyranosyl (1-->2)-beta-D-galactopyranoside (macrostemonoside P), (25R)-26-O-beta-D-glucopyranosyl-22-hydroxy-5beta-furost-1alpha, 2beta, 3beta, 26-tetraol-3-O-beta-D-glucopyranosyl (1-->2)-beta-D-galactopyranoside (macrostemonoside Q) and (25R)-26-O-beta-D-glucopyranosyl-22-hydroxyl-5beta-furost-2alpha, 3beta, 26-triol-3-O-beta-D-glucopyranosyl (1-->2) [beta-D-glucopyranosyl (1-->3)]-beta-D-glucopyranosyl (1-->4)-beta-D-galactopyranoside (macrostemonoside R), respectively. Their cytotoxic activities on several cancer cell lines including solid tumor (HepG2, MCF-7, NCI-H460 and SF-268) and drug resistant tumor (R-HepG2) were investigated and five compounds showed diverse cytotoxity to these cancer cell lines which suggest that they might be used as potential leading compounds to cure cancer diseases.

Cancer cell lines

BETA (programming language)

Liliaceae

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Citations (25)

A New Minor Saponin from the Leaves ofPanax ginseng

Planta Medica (1990)

Shaolin Zhang Tadahiro Takeda Tinru Zhu Yingjie Chen Xin‐Sheng Yao

Seventeen compounds were isolated from the leaves of PANAX GINSENG C. A. Meyer. Among them, a new minor saponin was established as 3beta,6alpha,12beta-trihydroxy-dammar-20(22), 24-diene-6- O-alpha- L-rhamno-pyranosyl-(1-->2)-beta- D-glucopyranoside ( 2). Fourteen compounds were identified as 20( R)-protopanaxadiol ( 1), 20( R)-protopanaxatriol, ginsenoside-Rh (3), 20( R)-ginsenoside-Rh (2), 20( S)-ginsenoside-Rh (2), ginsenoside-Rh (1), -Rg (3), -Rg (2), -Rg (1), -Re, -Rd, -Rc, -Rb (2), -Rb (1); the others are still under investigation.

Araliaceae

Protopanaxadiol

10.1055/s-2006-960963

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Citations (27)