Objective To investigate the prevalence of depression and its risk factors in community elderly people at high risk of ischemic stroke.Methods Four hundred and sixty-nine elderly people with their age≥60years sampled from 4communities in Hexi District of Tianjin were divided into depression group(n=146)and non-depression group(n=323).Their depression was assessed according to the Hamilton's Depression Scale(edition 17).Results Of the 469 elderly people at high risk of ischemic stroke,146(31.1%)suffered from depression.The incidence of depression was significantly higher in females,singles,those with a history of depression and heart disease,those who had insufficient physical exercises,physical labourers,and those with a family history of ischemic stroke of depression group than in those of non-depression group(P0.05).Logistic regression analysis revealed that females,singles,history of heart disease and family history of ischemic stroke were the independent risk factors for depression in community elderly people at high risk of ischemic stroke(OR=2.542,95%CI:1.373-4.707,P=0.003;OR=4.272,95%CI:1.706-10.696,P=0.002;OR=2.734,95%CI:1.728-4.325,P=0.000;OR=1.583,95%CI:1.013-2.474,P=0.044).Conclusion Mild depression is more commonly observed in community elderly people at high risk of ischemic stroke.It should be diagnosed and treated as early as possible.