Seyed Soheil Saeedi Saravi

University Hospital of Zurich

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Mohammad Shokrzadeh

Mazandaran University of Medical Sciences

Jürg H. Beer

Kantonsspital Baden

Ahmad Reza Dehpour

Tehran University of Medical Sciences

Giovanni G. Camici

University of Zurich

Thomas F. Lüscher

Royal Brompton & Harefield NHS Foundation Trust

Luca Liberale

University of Genoa

Nicole R. Bonetti

University Hospital of Zurich

Benoı̂t Pugin

ETH Zurich

Florentin Constancias

ETH Zurich

Lisa Pasterk

University of Zurich

Cooperative Institutions

University of Zurich

Tehran University of Medical Sciences

Mazandaran University of Medical Sciences

University Hospital of Zurich

Kantonsspital Baden

Harvard University

University Hospital of Basel

Shahid Beheshti University of Medical Sciences

University of Basel

Brigham and Women's Hospital

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Acute kidney injury associated with COVID-19: a prognostic factor for pulmonary embolism or co-incidence?

European Heart Journal (2020)

Seyed Soheil Saeedi Saravi Massimo Barbagallo Martin F. Reiner Hans Ruedi Schmid Jonas Rutishauser

An 81-year-old gentleman presented with fever (39.1 C), cough, dysuria, and urinary tract infection, which warranted antibiotic therapy.Medical history included insulin-dependent type 2 diabetes mellitus, arterial hypertension, and third-degree atrioventricular block with an implanted pacemaker.The patient was intubated and required mechanical ventilation for severe respiratory failure (Horowitz index of 64.2 mmHg) 6 days after hospitalization.SARS-CoV-2 polymerase chain reaction (PCR) test on nasopharyngeal swabs was positive and chest computed tomography (CT) illustrated bilateral ground-glass opacities (Panel A).Laboratory tests showed a remarkable increase in the inflammatory cytokine interleukin-6 (270.6 pg/mL) and C-reactive protein (CRP; 222.7 mg/L).In the second week, he developed acute kidney injury (AKI) [creatinine, 296 lmol/L; blood urea nitrogen (BUN), 14.6 lmol/L, and estimated glomerular filtration rate (eGFR) 16 mL/ min/1.73m 2 ], and consequently continuous haemodialysis was initiated.Fifteen days later, D-dimer levels were strikingly elevated (15 293 lg/L), and CT pulmonary angiography revealed segmental pulmonary embolism (PE) in the right upper lobe (Panel B) without signs of right ventricular failure (Supplementary material online, Video 1).ECG showed new onset of atrial fibrillation (Panel C).Anticoagulation with unfractionated heparin was implemented.The patient remained in the intensive care unit until recovery of pulmonary function, but dialysis continued for 24 days to be prepared for discharge.Although causes of PE and AKI are multifactorial, common mechanisms such as the proinflammatory cytokine storm, endothelial injury, hypercoagulability, and direct infection of both endothelial and epithelial cells in the kidney may underlie a prognostic and predictive role for AKI for PE in patients with severe COVID-19.

2019-20 coronavirus outbreak

Pulmonary Injury

10.1093/eurheartj/ehaa637

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Citations (1)

Copper and selenium levels in women with second-trimester induced abortion in Mazandaran, 2009: A case control study

Pharmaceutical and Biomedical Research (2015)

Zoleikha Atarod Nima Emadi Seyed Soheil Saeedi Saravi Mona Modanloo Mohammad Shokrzadeh

Copper and selenium levels in women with second-trimester induced abortion in Mazandaran, 2009: A case control study

10.18869/acadpub.pbr.1.1.44

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Citations (2)

Role of Pesticides in Human Life in the Modern Age: A Review

InTech eBooks (2011)

Seyed Soheil Saeedi Saravi Mohammad Shokrzadeh

Food production capacity is faced with an ever-growing number of challenges, including a world population expected to grow to nearly 10 billion by 2050 and a falling ratio of arable land to population. Based on evidences, in 1900 there were 1.6 billion people on the planet; in 1992 this had risen to 5.25 billion and by the year 2050 it will reach 10 billion. World population is increasing by 97 million per year. This explosive increase in world population is mostly in developing countries and this is where the need for food is greatest and starvation threatens human life; as, FAO1 estimates that 500 million are already undernourished (Anon, 1990a). Civilization has been combating weeds, insects, diseases and other pests throughout history and there are many examples of how these pests have had a major impact on humans. One of the worst examples is the Black Plaque of Europe in the fourteenth century when millions died from a bacterial disease spread by fleas from rats (Hock et al., 1991). Another example is the infamous Irish potato famine of the nineteenth century in which millions died and many more were forced to emigrate. A fungus also destroyed the entire German potato crop in the early twentieth century resulting in 700,000 deaths from starvation (Anon, 1992b). Thus, food plays a vital and strategic role in growing global population. But, food production is encounter to different limits. For example, there is a limit to new areas to cultivate; therefore we must increase agricultural production from the areas available. However, the specialization of production units has led to the image that agriculture is a modern miracle of food production (Stoytcheva, 2011). In our global society there is a place for people to grow and consume organic food, but if all our farmers decided against using farm chemicals, we would soon find ourselves in a grave situation. Without the use of farm chemicals, the production and quality of food would be severely jeopardized with estimates that food supplies would immediately fall to 30 to 40% due to the ravages of pests (Anon, 1990b; Anon, 1992a). While there are mountains of food in Europe and the US, this represents only 45 days food supply for the world. Only part of the problem is distribution and the ability to pay for purchases.

Famine

Arable land

World population

10.5772/18827

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Cytotoxicity of Sambucus ebulus on cancer cell lines and protective effects of vitamins C and E against its cytotoxicity on normal cell lines

AFRICAN JOURNAL OF BIOTECHNOLOGY (2013)

Seyed Soheil Saeedi Saravi Mohammad Shokrzadeh Farshad H. Shirazi

Isolation and identification of potent anti-tumor compounds from medicinal plants, has motivated researchers to screen plant species for anti-tumor effects. Regarding the traditional utilization of Sambucus ebulus , Iranian native botany and its active ingredients (e.g. ebulitin and ebulin 1), cytotoxicity of ethyl acetate extract from S. ebulus (SEE) on HepG2 and CT26 cancer cell lines was investigated. Also, protective effects of vitamins C and E against SEE-induced cytotoxicity on normal cell lines were studied. Cytotoxicity of SEE on cancer (HepG2 and CT26) and normal (CHO and rat fibroblast) cell lines was evaluated by MTT assay. IC 50 of SEE on the cell lines was assessed. Furthermore, IC 50 of SEE on normal cell lines with exposure to vitamins C, E and C+E was studied. SEE possessed lower IC50 in cancer cell lines compared with normal cell lines. It manifested high cytotoxicity that can act as anticancer compound. Also, cytotoxicity of SEE on normal cell lines in presence of vitamins C+E, E and C decreased. The results demonstrate that SEE is an effective cytotoxic agent on liver and colon cancer cells and suggest that vitamins C and E may protect normal cells, when SEE were used in cancer therapy in future. Keywords : Sambucus ebulus , cytotoxicity, IC 50 , MTT assay, cell line, vitamins C and E. African Journal of Biotechnology Vol. 12(21), pp. 3360-3365

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Synergistic effect of rapamycin and metformin against germ cell apoptosis and oxidative stress after testicular torsion/detorsion-induced ischemia/reperfusion in rats

Biomedicine & Pharmacotherapy (2018)

Morteza Ghasemnejad‐Berenji Mahmoud Ghazi‐Khansari Sarvin Pashapour Abbas Jafari Iraj Yazdani

Malondialdehyde

Glutathione reductase

Terminal deoxynucleotidyl transferase

10.1016/j.biopha.2018.06.012

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Citations (32)

Nitric Oxide Synthase - Simple Enzyme-Complex Roles

InTech eBooks (2017)

Seyed Soheil Saeedi Saravi

Nitric Oxide Synthase - Simple Enzyme-Complex Roles provides information on nitric oxide synthase, a biomolecule of key importance for the different biological systems, including central and peripheral nervous, cardiovascular, and reproductive systems. With recent links to the role of nitric oxide in the reactions that can impact cell signaling, and discoveries surrounding the complex role of nitric oxide synthase that have increased research attention across the fields of cell and molecular biology, physiology, pharmacology, toxicology, neuroscience, cardiology, urology, and endocrinology, this book tries to provide a comprehensive overview of biology/pathobiology of nitric oxide synthases and a perspective from possible therapeutic indication of the enzyme inhibitors.

NOS1

10.5772/63170

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Survey and determination of Anzali wetland trophic state through geographic information systems (GIS)

Toxicological & Environmental Chemistry Reviews (2008)

Abbas Akbarzadeh Hasan-Ali Laghai Seyed Masoud Monavari Shaban Ali Nezami Mohammad Shokrzadeh

The trophic state of the Anzali wetland was determined by nutrient analysis, indicating an alarming hypertrophic state. The Anzali wetland is environmentally and economically one of the most important ecosystems that is located in north-west Iran. This wetland was registered as a Ramsar site in September 1975, but due to many problems, particularly eutrophication created by excessive amounts of nutrients, it was registered in the Montreux record. This study was conducted for a year on 21 stations in three zones including receiving rivers, surface water and exiting rivers. Geographic information systems were used to better understand the prevailing situation. Analysis was conducted according to international standards and classification of OECD for freshwaters. The indicators used were levels of total nitrogen (TN) and total phosphorous (TP), and the trophic state index (TSI). Data showed an increase of excess nutrients from domestic and agricultural sources, leading to human, cultural eutrophication processes rather than natural eutrophication.

Trophic state index

10.1080/02772240701850681

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Heavy metals (Zn, Pb, Cd and Cr) in fish, water and sediments sampled form Southern Caspian Sea, Iran

Toxicology and Industrial Health (2010)

Saleh Tabari Seyed Soheil Saeedi Saravi Gholamali A Bandany Atena Dehghan Mohammad Shokrzadeh

Environmental pollution is a worldwide problem, heavy metals belonging to the most important pollutants. The progress of industries has led to increased emission of pollutants into ecosystems. Southern Caspian Sea coast is one of the most important aquasystems at the eastern south of Caspian Sea, which receives effluents discharges from heavily industrialized and highly populated settlements. Metals tend to accumulate in water and move up through the food chain. So, studies to ascertain the level of heavy metals in environment and determine potentially hazardous levels for human are necessary. In this investigation, concentration of four heavy metals (zinc [Zn], chromium (Cr), cadmium, [Cd] and lead [Pb]) in three species of most-consumed fishes, water and sediments have been determined. Samples were collected from 10 stations along the Southern coast of Caspian Sea, in spring 2008. Heavy metal concentrations were measured by graphite furnace atomic absorption spectrometry. Then, the data were analyzed by means of one-way analysis of variance (ANOVA) statistical analysis. The results showed that the highest concentration of heavy metals in water and fish and sediment samples were related to Pb and Zn. The minimal and maximal concentrations of these metals in fishes, water and sediments were 53.67-2360.67 and 50.36-2497.25 for Pb and Zn, respectively. However, the observed heavy metals concentrations in fish, water and sediments were below the recommended limits. The investigation showed elevating levels of heavy metals in environment. Thus, a serious notification to industrial and manmade pollution, which can lead to ecosystem and food chain contamination, is necessary.

Bioconcentration

Marine ecosystem

10.1177/0748233710377777

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Citations (82)

Meet the Editorial Board Member

Anti-Cancer Agents in Medicinal Chemistry (2022)

Seyed Soheil Saeedi Saravi

Editorial board

10.2174/187152062207220303151533

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