Objective: To determine the effect on renal function of postoperative low-dose dopamine in volume-replete patients after elective, major vascular abdominal surgery. Design: Randomized, double-blind...
Merikangas KR, Dierker LC, Szatmari P. Psychopathology among offspring of parents with substance abuse and/or anxiety disorders: a high-risk study. J Child Psychol Psychiat1998 Jul; 39 : 711 –20 [OpenUrl][1][CrossRef][2][PubMed][3][Web of Science][4] Question Are parental substance abuse and anxiety disorders risk factors for psychopathology in offspring? Cohort study. New Haven, Connecticut, USA. 192 children (mean age 12 y, 51% boys) of 123 white parents (mean age 39 y). There were 77 children of 52 parents with substance abuse disorders, 58 children of 36 parents with anxiety disorders, and 57 children of 35 parents with no history of psychiatric disorders (control group parents). Parents were recruited from alcohol, drug, anxiety, and general treatment settings or by a random procedure. Exclusion criteria were organic mental impairment, schizoaffective disorder, or schizophrenia. Both parents of each child were independently interviewed for … [1]: {openurl}?query=rft.jtitle%253DJournal%2Bof%2Bchild%2Bpsychology%2Band%2Bpsychiatry%252C%2Band%2Ballied%2Bdisciplines%26rft.stitle%253DJ%2BChild%2BPsychol%2BPsychiatry%26rft.aulast%253DMerikangas%26rft.auinit1%253DK.%2BR.%26rft.volume%253D39%26rft.issue%253D5%26rft.spage%253D711%26rft.epage%253D720%26rft.atitle%253DPsychopathology%2Bamong%2Boffspring%2Bof%2Bparents%2Bwith%2Bsubstance%2Babuse%2Band%252For%2Banxiety%2Bdisorders%253A%2Ba%2Bhigh-risk%2Bstudy.%26rft_id%253Dinfo%253Adoi%252F10.1017%252FS0021963098002522%26rft_id%253Dinfo%253Apmid%252F9690934%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx [2]: /lookup/external-ref?access_num=10.1017/S0021963098002522&link_type=DOI [3]: /lookup/external-ref?access_num=9690934&link_type=MED&atom=%2Febnurs%2F2%2F2%2F53.atom [4]: /lookup/external-ref?access_num=000074885500011&link_type=ISI
Objective To report two cases of fatal brown snake envenomation in adults despite the use of appropriate antivenom. Clinical features Two men, aged 42 and 39, one with a history of hypertension, suffered fatal brown snake envenomation in Queensland. One believed he had been stung by a wasp. Both developed cardiorespiratory failure within one hour of the bite, followed by coagulopathy and pulmonary oedema. One patient developed fulminant multiorgan failure. Intervention Both patients died despite the administration of large doses of appropriate antivenom and full supportive care. Conclusion Brown snake bites remain extremely dangerous despite the availability of specific antivenom. In severe cases associated with myocardial depression and gross coagulopathy, death may occur rapidly despite the use of conventional doses of antivenom. In such patients the antivenom requirement may be much greater than is currently recommended.
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