4,4'-Methylene-bis(2-chloroaniline) (MOCA) is widely used as a curing agent in the plastics industry. The determination of the covalently bound reaction products to hemoglobin (Hb) has been investigated as a biomonitoring method for occupational exposure to this potential human carcinogen. Initial studies using the 14C-ring-labeled MOCA showed that 24 hr after a single IP dosage to rats (3.74 mumole/kg), 0.08% of the administered dose was adducted to the Hb, and base hydrolysis liberated 38% of the bound radioactivity. The only product released on hydrolysis was the parent diamine. A specific and sensitive assay procedure using capillary gas chromatography-mass spectrometry has been developed for determining the base-released MOCA adduct down to levels of 20 pmole/g Hb. This method has been used to establish a linear dose-response relationship in IP dosed rats between production of the adduct and dose of MOCA (3.74-44.94 mumole/kg). It is proposed to use analysis of the Hb adduct as a dosimeter for industrial workers exposed to MOCA.
Journal Article Reduction of nitromin to nitrogen mustard: unscheduled DNA synthesis in aerobic or anaerobic rat hepatocytes, JB1, BL8 and Walker carcinoma cell lines Get access Ian N. H. White, Ian N. H. White Search for other works by this author on: Oxford Academic PubMed Google Scholar Mohammad Suzanger, Mohammad Suzanger 1Present address: Department of Pharmaceutical Sciences, University of IsfahanIsfahan, Iran Search for other works by this author on: Oxford Academic PubMed Google Scholar A. Robin Mattocks, A. Robin Mattocks Search for other works by this author on: Oxford Academic PubMed Google Scholar Eric Bailey, Eric Bailey Search for other works by this author on: Oxford Academic PubMed Google Scholar Peter B. Farmer, Peter B. Farmer Search for other works by this author on: Oxford Academic PubMed Google Scholar Thomas A. Connors Thomas A. Connors Search for other works by this author on: Oxford Academic PubMed Google Scholar Carcinogenesis, Volume 10, Issue 11, November 1989, Pages 2113–2118, https://doi.org/10.1093/carcin/10.11.2113 Published: 01 November 1989 Article history Received: 25 May 1989 Revision received: 14 August 1989 Accepted: 16 August 1989 Published: 01 November 1989
The objective of the study was to examine and compare the hemodynamic impact of saddle vs non-saddle pulmonary embolism in a selected patient population. Brief Communication from Journal of Invasive Cardiology. Pulmonary embolism thrombosis Thrombectomy normotensive shock
CI-960 is a new fluoroquinolone with enhanced in vitro activity against gram-positive pathogens. The efficacy of the drug was compared with that of vancomycin by using the rabbit model of nafcillin- and ciprofloxacin-susceptible and -resistant Staphylococcus aureus endocarditis. Animals received intravenous therapy with CI-960, 20 mg/kg of body weight every 8 h, or vancomycin, 17.5 mg/kg every 6 h, for 4 days. In a comparison with the effects on untreated controls, both antimicrobial agents effectively cleared bacteremia and significantly reduced bacterial counts in vegetations and tissues of animals infected with any of the test strains. In some cases, the efficacy of CI-960 was superior to that of vancomycin. The therapeutic activity of CI-960 was reduced, but still very good, against ciprofloxacin-resistant strains. One rabbit infected with such a strain and treated with CI-960 was found to harbor a small number of vegetation-associated organisms resistant to the drug at fivefold its original MIC; this was associated with a microbiological, but not a clinical, failure of therapy. We conclude that CI-960 is as effective as vancomycin is in this model of a serious systemic S. aureus infection, including that caused by strains resistant to ciprofloxacin. Increases in CI-960 MICs may develop during therapy of infections caused by strains highly resistant to ciprofloxacin, but they appear unlikely to occur in ciprofloxacin-susceptible strains.
In a previous communication (Bailey, Murphy and West, 1961) we reported the urinary excretion of prednisolone and prednisone of a number of children who were not responding to prednisolone therapy.From the findings we concluded that some ill children absorb only a fraction of the dose of prednisolone given to them and we suggested that until a surer way of giving prednisolone was found it might be wise to give the more water- soluble steroid triamcinolone which they absorbed well.Recently, highly water-soluble prednisolone phosphate tablets have become available, so we have repeated some of the studies.Urine specimens have been provided as previously by Professor R. S. Illingworth and Dr. John Lorber of the University Department of Child Health.The results are reported because they suggest that the phosphate tablets will prove of considerable clinical value.Methods The tablets of prednisolone (5 mg.) were given whole in some cases and crushed in others.The phosphate tablets, containing 5 mg. of prednisolone, were given dissolved in water.Aliquots of the urine collections were extracted with ethyl acetate; the extracts were
K. Grob, J. R. Chapman, E. Bailey, P. B. Farmer, J. B. Campbell, D. E. Wells, A. A. Cowan, K. E. Hall, P. W. Brooks, R. J. Law, J. D. Baty and R. G. Willis, Anal. Proc., 1982, 19, 233 DOI: 10.1039/AP9821900233
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