Xiaochun Teng

Second Hospital of Anhui Medical University

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i-10 index

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Weiping Teng

China Medical University

Zhongyan Shan

First Hospital of China Medical University

Chenling Fan

China Medical University

Xiaoguang Shi

China Medical University

Di Teng

China Medical University

Xiaohui Yu

China Medical University

Yushu Li

First Hospital of China Medical University

Yongze Li

Institute of Biophysics

Jinyuan Mao

First Hospital of China Medical University

Yanyan Chen

Xinjiang Medical University

Cooperative Institutions

China Medical University

110

First Hospital of China Medical University

Shanghai Jiao Tong University

Chinese Academy of Medical Sciences & Peking Union Medical College

Huazhong University of Science and Technology

Sun Yat-sen University

Chinese Academy of Sciences

Fudan University

Central South University

Peking University

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An Age-Specific Serum Thyrotropin Reference Range for the Diagnosis of Thyroid Diseases in Older Adults: A Cross-Sectional Survey in China

Thyroid (2018)

Xiaodan Zhai Le Zhang Lulu Chen Xiaolan Lian Chao Liu

Background: The fact that serum thyrotropin (TSH) levels increase with age may influence the diagnosis of thyroid diseases in older adults. This study aimed to establish an age-specific serum TSH reference range, examine the prevalence of thyroid diseases in older adults ≥65 years, and analyze the risk factors. Methods: A cross-sectional study of adult populations in 10 cities in China was conducted from 2010 to 2011. A total of 15,008 subjects were randomly selected and completed the present study. Urinary iodine concentration, serum TSH, thyroid peroxidase antibody (TPOAb), and thyroglobulin antibody (TgAb) titers were measured. Thyroid ultrasonography and questionnaires were completed by all the subjects. When the TSH level was abnormal, free thyroxine and/or free triiodothyronine levels were measured. Results: When the reference range of the general population was used, the prevalence rates of overt hypothyroidism (Ohypo) and subclinical hypothyroidism (Shypo) in older adults ≥65 years were significantly higher than those in younger adults <65 years (2.09% vs. 0.80% and 19.87% vs. 16.23%, respectively; p < 0.001). Positive TPOAb and positive TgAb were associated with the prevalence of Shypo in older adults. An age-specific serum TSH reference range was formulated according to guidelines set forth by the National Academy of Clinical Biochemistry. Both the median and upper limit values of serum TSH in older adults were higher than those in younger adults (2.58 [0.75-8.86] mIU/L vs. 2.38 [0.76-6.57] mIU/L; p < 0.001). Using the age-specific serum TSH reference range, the prevalence of Shypo in older adults was 3.3%, which was significantly lower than the prevalence based on the reference range of the general population (3.3% vs. 19.87%). The prevalence rates of Ohypo, overt hyperthyroidism (Ohyper), and subclinical hyperthyroidism (Shyper) did not change much (Ohypo: 1.6% vs. 2.09%; Ohyper: 0.7% vs. 0.52%; and Shyper: 3.8% vs. 0.73%). Positive TPOAb, but not positive TgAb, was also associated with the prevalence of Shypo as diagnosed with the age-specific serum TSH reference range. Conclusion: The serum TSH level increases with age, which may represent a normal compensatory phenomenon in older adults ≥65 years. To prevent misdiagnosis and mistreatment, the use of an age-specific serum TSH reference range is recommended in older adults for the diagnosis of thyroid diseases.

Reference range

Thyroid peroxidase

Subclinical infection

Cross-sectional study

Thyroglobulin

10.1089/thy.2017.0715

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Citations (55)

Supplementary Material for: Spatial transcriptomics of aging rat ovaries reveals unexplored cell subpopulations with reduced antioxidative defence

Figshare (2023)

Jian Shen Liu Y Xiaochun Teng Jin Liu Liang Feng

Introduction: Ovarian aging is characterized by a gradual decline in quantity and quality of oocytes, and lower chance of fertility. Better understanding the genetic modulation during ovarian aging can further address available treatment options for aging-related ovarian diseases and fertility preservation. Methods: A novel technique spatial transcriptomics (ST) was used to investigate the spatial transcriptome features of rat ovaries. Transcriptomes from ST spots in the young and aged ovaries were clustered using differentially expressed genes. These data were analyzed to determine the spatial organization of age-induced heterogeneity and potential mechanisms underlying ovarian aging. Results: In this study, ST technology was applied to profile the comprehensive spatial imaging in young and aged rat ovary. Fifteen ovarian cell clusters with distinct gene-expression signatures were identified. The gene expression dynamics of granulosa cell clusters revealed three sub-types with sequential developmental stages. Aged ovary showed a significant decrease in the number of granulosa cells from antral follicle. Besides, a remarkable rearrangement of interstitial gland cells was detected in aging ovary. Further analysis of aging-associated transcriptional changes revealed that the disturbance of oxidative pathway was a crucial factor in ovarian aging. Conclusions: This study firstly described an aging-related spatial transcriptome changes in ovary, and identified the potential targets for prevention of ovarian aging. These data may provide the basis for further investigations of the diagnosis and treatment of aging-related ovarian disorders.

10.6084/m9.figshare.24151494

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Chronic iodine excess does not increase the incidence of hyperthyroidism: a prospective community-based epidemiological survey in China

European Journal of Endocrinology (2007)

Fan Yang Zhongyan Shan Xiaochun Teng Yushu Li Haixia Guan

An increasing incidence of hyperthyroidism has been observed when iodine supplementation has been introduced to an iodine-deficient population. Moreover, the influence of chronic more than adequate or excessive iodine intake on the epidemiological features of hyperthyroidism has not been widely and thoroughly described. To investigate the influences of different iodine intake levels on the incidence of hyperthyroidism, we conducted a prospective community-based survey in three communities with mild-deficient, more than adequate (previously mild deficient iodine intake), and excessive iodine intake.In three rural Chinese communities, a total of 3761 unselected inhabitants aged above 13 years participated in the original investigation and 3018 of them received identical examinations after 5 years. Thyroid function, levels of thyroid peroxidase antibody (TPOAb), thyroglobulin antibody and urinary iodine excretion were measured and thyroid ultrasound examination was also performed.In three communities, median urinary iodine excretion was 88, 214, and 634 microg/l (P<0.05) respectively. The cumulative incidence of hyperthyroidism was 1.4, 0.9, and 0.8% (P>0.05) respectively. Autoimmune hyperthyroidism was predominant in thyroid hyperfunction in all the three cohorts. Either positive TPOAb (>50 U/ml) or goiter in original healthy participants was associated with the occurrence of unsuspected hyperthyroidism in 5 years (logistic regression, OR=4.2 (95% CI 1.7-8.8) for positive TPOAb, OR=3.1 (95% CI 1.4-6.8) for goiter).Iodine supplementation may not induce an increase in hyperthyroidism in a previously mildly iodine-deficient population. Chronic iodine excess does not apparently increase the risk of autoimmune hyperthyroidism, suggesting that excessive iodine intake may not be an environmental factor involved in the occurrence of autoimmune hyperthyroidism.

Thyroid peroxidase

Thyroglobulin

10.1530/eje-06-0651

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The Characteristics of Iodine Nutrition Status in China After 20 Years of Universal Salt Iodization: An Epidemiology Study Covering 31 Provinces

Thyroid (2021)

Tingting Liu Yongze Li Di Teng Xiaoguang Shi Li Yan

Background: Despite the implementation of the universal salt iodization (USI) program for correction of iodine deficiency in China for ∼20 years, the actual iodine nutrition status of Chinese residents and the prevalence of iodine deficiency and iodine excess are issues that need to be addressed. This nationally representative cross-sectional study was conducted across all 31 provinces of mainland China to gather extensive data on iodine nutrition status and the influential factors. Methods: This study included 78,470 participants, aged 18 years or older, who were interviewed and asked to answer a questionnaire. Urine iodine concentration (UIC) was measured by the inductively coupled plasma mass spectrometry method, and goiter was examined by thyroid ultrasonography. In addition, sixty 9-11 years old school children in each province were randomly selected to evaluate the UIC and thyroid ultrasonography. The iodine nutrition status was determined according to the World Health Organization guidelines. Results: The iodized salt coverage was 95.37%. The median urine iodine (MUI) was 177.89 μg/L (interquartile range [IQR], 117.89-263.90 μg/L) and goiter prevalence was 1.17% (confidence interval [95% CI 0.95-1.43]) in the adult population. The MUI was 199.75 μg/L (IQR, 128.41-303.37 μg/L) in school-age children, and goiter prevalence was 3.50% [95% CI, 2.93-4.13]. The percentage of individuals with UIC <50 μg/L was 3.43%, <20%. Analysis indicated that sex, age, geographic factors, body mass index, and smoking habits influence the iodine nutrition level. Conclusion: The mandatory USI program has successfully eliminated iodine deficiency disorders, and the findings indicate that the iodine nutrition level in the general population is within the safe range.

Iodised salt

Interquartile range

Cross-sectional study

10.1089/thy.2021.0301

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Citations (19)

自己免疫性多内分泌分泌物の研究進展【JST・京大機械翻訳】

Zhongguo Shiyong Neike Zazhi (2016)

Xiaochun Teng Shan Zhongyan

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Annexin A1 mimetic peptide Ac2 26 alleviates renal inflammatory injury in diabetic mouse model by suppressing p38MAPK/NF κB

Tropical Journal of Pharmaceutical Research (2022)

Kangyi Zhang Xiaochun Teng

Purpose: To investigate the protective role of mimetic peptide Ac2-26 of annexin A1 (ANXA1) in regulating p38MAPK/NF-κB for renal inflammatory injury in a diabetic mouse model. Methods: The mice were divided into three groups (control, model and Ac2-26; n = 8). Control was untreated, normal mice, while Ac2-26 was treated with mimetic peptide Ac2-26 after induction of type I diabetes with streptozotocin (60 mg/kg). The model group was not further treated after induction of diabetes. The fasting blood glucose (FBG), blood lipid, and renal function were evaluated. Serum inflammatory factors in renal tissue were also assessed. Results: Compared with the model group, there was a significant decrease in the levels of FBG, blood lipids (TG, TC, LDL and ox-LDL), KI, 24 h urinary protein, Cr and BUN, and significant increase in body weight in AC2-26 group (p < 0.001). There was a marked decrease in TNF-α, IL-6, IL-1β, and IL-18 levels, as well as levels of mRNA and protein expressions of p38MAPK, NF-κBP6 and ANXA1 in AC2-26 group when compared with the model group (p < 0.001). Conclusion: ANXA1 is the target gene of p38MAPK, and mimetic peptide Ac2-26 alleviates renal inflammation by suppressing p38MAPK/NF-κB pathway, thus improving renal function in diabetic mice models. This finding suggests a probable approach to developing an effective treatment for renal inflammation in diabetic renal injury.

Annexin A1

Proinflammatory cytokine

Rat model

Renal Injury

10.4314/tjpr.v21i8.9

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Analysis of Influence Factors of Thyroid Volume in Healthy Adults

Zhongguo Yike Daxue xuebao (2003)

Xiaochun Teng

Objective: Our aim was to analyze influence factors of thyroid volum (TV) in healthy adults. Methods: Questionnaire, thyroid function, thyroid autoantibody assay and thyroid B-ultrasound scan were performed in population in 3 areas with different iodine intake. After screening the healthy adults, we investigated the relationship of TV and age, sex, body height, body weight, iodine intake, serum thyroid-stimulating hormone (TSH) level. Results: Adult TV had no relationship with age, sex, menopause, smoking or drinking. With the decrease of iodine intake, TV increased. TV had positive correlation with body height, body weight and body surface area(P0.01), and negative correlation with serum TSH level(P0.01). The TV in men was higher than that in women(P0.05). But the ratio of TV to body weight between sexes showed no obvious difference. Conclusion: In adults whose median urinary iodine (MUI) are between 100 to 600 μg/L, TV increases with the increasing of body height, body weight, especially body surface area, decreases with the increasing of iodine intake and serum TSH level, and has no relationship with age, sex, menopause, smoking and drinking.

Anti-thyroid autoantibodies

Body surface area

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Resistance to thyroid hormone beta coexisting with papillary thyroid carcinoma—two case reports of a thyroid hormone receptor beta gene mutation and a literature review

Frontiers in Genetics (2022)

Yingxin Fang Tingting Liu Huimin Hou Zhihong Wang Zhongyan Shan

Resistance to thyroid hormone beta (RTHβ) is an autosomal dominant hereditary disorder that is difficult to diagnose because of its rarity and variable clinical features, which are caused by mutations in the thyroid hormone receptor beta (THRB) gene. Recent studies have indicated a close association between THRB mutations and human cancers, but the mechanistic role of THRB mutations in carcinogenesis is unknown. Herein, we report two cases of RTHβ coexisting with papillary thyroid carcinoma (PTC) and their follow-up results. Two female patients presented with elevated serum thyroid hormone levels and nonsuppressed thyrotropin (TSH). Genetic analysis showed that each patient had a THRB gene mutation (p.P453T and p. R320H). Based on the results of ultrasound-guided fine-needle aspiration biopsy, the thyroid nodules were suspected to be PTC. Intraoperative pathology confirmed that the two patients had PTC with multifocal carcinoma of both lobes. One patient underwent total thyroidectomy and central lymph node dissection, and the other underwent total thyroidectomy alone. Following surgery, large doses of levothyroxine were administered to suppress TSH levels and prevent recurrent or persistent disease. However, it is difficult to continually suppress TSH levels below the upper limit of the normal range. To date, the two patients have experienced no recurrence of PTC on ultrasound.

Levothyroxine

Thyroid hormone receptor

10.3389/fgene.2022.1014323

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Citations (0)

Effects of an Increased Iodine Intake on Thyroid Diseases

Elsevier eBooks (2009)

Weiping Teng Zhongyan Shan Xiaochun Teng

10.1016/b978-0-12-374135-6.00125-4

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Citations (3)

Smoking Is Positively Associated with Antithyroperoxidase Antibodies and Antithyroglobulin Antibodies in Populations with Mildly Deficient Iodine Intake