Benedetta Storti

Fondazione IRCCS Istituto Neurologico Carlo Besta

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Carlo Ferrarese

Azienda Ospedaliera San Gerardo

Ildebrando Appollonio

University of Milano-Bicocca

Anna Bersano

Fondazione IRCCS Istituto Neurologico Carlo Besta

Lucio Tremolizzo

University of Milano-Bicocca

Nicola Rifino

Fondazione IRCCS Istituto Neurologico Carlo Besta

Isabella Canavero

Fondazione IRCCS Istituto Neurologico Carlo Besta

Isabella Canavero

Fondazione IRCCS Istituto Neurologico Carlo Besta

Fulvio Da Re

University of Milano-Bicocca

Vittoria Aprea

University of Milano-Bicocca

Jacopo C. DiFrancesco

Istituti di Ricovero e Cura a Carattere Scientifico

Cooperative Institutions

Fondazione IRCCS Istituto Neurologico Carlo Besta

University of Milano-Bicocca

Istituti di Ricovero e Cura a Carattere Scientifico

University of Milan

Azienda Ospedaliera San Gerardo

Ospedale Papa Giovanni XXIII

Ospedale Maggiore

Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico

University College London

University of Bergamo

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Delirium in your house: a survey during General Practitioner-programmed home visits

Aging Clinical and Experimental Research (2021)

Lucio Tremolizzo Lorena Bargossi Benedetta Storti Carlo Ferrarese Giuseppe Bellelli

Abstract Objectives To assess the prevalence of delirium (DEL) among older patients living at home and periodically visited by their General Practitioners (GPs). Design Observational study. Setting In Italy, programmed home visits by the GPs are regularly scheduled for their vulnerable and frail patients who are often on poly-drug regimens and suffering from dementia. Participants N = 102 patients among those receiving programmed home visits by n = 6 GP based in the Brianza area (Lombardy). Measurements Patients were screened for delirium with the Italian version of the 4AT, with a score ≥ 4 considered as a positive indicator for DEL. The Charlson Comorbidity Index (CCI), the Short Physical Performance Battery (SPPB), the presence of dementia, and benzodiazepine (BZD) use were recorded. Results DEL+ was detected in almost half of the recruited sample (44.1%), and it was clearly associated with increased comorbidity and decreased motor abilities. Pre-existing dementia was documented in most of DEL+ patients (71.1%), while this was the case for only a minority of DEL- (5.2%, p < 0.00001). Analogously, BZD use was over-represented in the DEL+ group with respect to the DEL− one (73.3% vs. 22.8%, p < 0.00001). Conclusions DEL prevalence as detected by GP during programmed home visits is surprisingly high, and related to motor impairment, comorbidities (among which dementia), and BZD use. DEL prompt recognition should be one of the goals of GP-programmed home visits, since this treatable and preventable condition is associated to an elevated burden of frailty and risk of death.

Charlson comorbidity index

10.1007/s40520-021-01806-1

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Electrophysiological features of acute inflammatory demyelinating polyneuropathy associated with SARS-CoV-2 infection

Neurophysiologie Clinique (2021)

Antonino Uncini Camillo Foresti Barbara Frigeni Benedetta Storti Maria Cristina Servalli

Critical illness polyneuropathy

10.1016/j.neucli.2021.02.001

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Citations (20)

Serum DBI and biomarkers of neuroinflammation in Alzheimer’s disease and delirium

Neurological Sciences (2020)

Elisa Conti Simona Andreoni Davide Tomaselli Benedetta Storti Francesco Brovelli

Alzheimer's disease (AD) patients often express significant behavioral symptoms: for this reason, accessible related biomarkers could be very useful. Neuroinflammation is a key pathogenic process in both AD and delirium (DEL), a clinical condition with behavioral symptoms resembling those of AD.A total of n = 30 AD patients were recruited together with n = 30 DEL patients and n = 15 healthy controls (CTRL). Serum diazepam binding inhibitor (DBI), IL-17, IL-6, and TNF-α were assessed by ELISA.DBI serum levels were increased in AD patients with respect to CTRL (+ 81%), while DEL values were 70% higher than AD. IL-17 was increased in DEL with respect to CTRL (+ 146%), while AD showed dispersed values and failed to reach significant differences. On the other hand, IL-6 showed a more robust increase in DEL with respect to the other two groups (+ 185% and + 205% vs. CTRL and AD, respectively), and TNF-α failed to show any change.DBI may be a very promising candidate for AD, perhaps marking psychomotor DEL-like symptoms, in view of developing future helping tool for practicing physicians. Furthermore, DBI rise in DEL offers novel cues for a better comprehension of the pathogenesis of this potentially fatal condition.

Pathogenesis

10.1007/s10072-020-04608-x

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The Octopus Trap of Takotsubo and Stroke: Genetics, Biomarkers and Clinical Management

Journal of Personalized Medicine (2022)

Isabella Canavero Nicola Rifino Maurizio Bussotti Tatiana Carrozzini Antonella Potenza

Takotsubo cardiomyopathy (TC) is a reversible cardiomyopathy mimicking an acute coronary syndrome, usually observed in response to acute stress situations. The association between acute ischemic stroke and TC is already known, since it has been previously reported that ischemic stroke can be both a consequence and a potential cause of TC. However, the precise pathophysiological mechanism linking the two conditions is still poorly understood. The aim of our review is to expand insights regarding the genetic susceptibility and available specific biomarkers of TC and to investigate the clinical profile and outcomes of patients with TC and stroke. Since evidence and trials on TC and stroke are currently lacking, this paper aims to fill a substantial gap in the literature about the relationship between these pathologies.

Stroke

Pathophysiology

10.3390/jpm12081244

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ALS Mimics due to Affection of the Cervical Spine: From Common Compressive Myelopathy to Rare CSF Epidural Collection

Case Reports in Neurology (2021)

Benedetta Storti Susanna Diamanti Lucio Tremolizzo Nilo Riva Christian Lunetta

Amyotrophic lateral sclerosis (ALS) is a clinically heterogeneous disease, with chameleon presentations and several mimics. Considering the poor prognosis of ALS, their precise and timely identification is pivotal. Affection of the cervical spine represents one potential source of ALS mimics that should never be missed, since it is potentially treatable. We hereby present 5 cases initially diagnosed as ALS but eventually found to have different kinds of cervical spine affection, from a common compressive myelopathy to a rare space-occupying cystic fluid collection.

Affection

Epidural space

Presentation (obstetrics)

10.1159/000512810

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Rare forms of cerebral amyloid angiopathy: pathogenesis, biological and clinical features of CAA-ri and iCAA

Frontiers in Neuroscience (2023)

Benedetta Storti Maria M. Gabriel Stefan Sennfält Isabella Canavero Nicola Rifino

Thanks to a more widespread knowledge of the disease, and improved diagnostic techniques, the clinical spectrum of cerebral amyloid angiopathy (CAA) is now broad. Sporadic CAA, hereditary CAA, CAA-related inflammation (CAA-ri) and iatrogenic CAA (iCAA) create a clinical and radiological continuum which is intriguing and only partially discovered. Despite being relatively rare, CAA-ri, an aggressive subtype of CAA with vascular inflammation, has gained growing attention also because of the therapeutic efficacy of anti-inflammatory and immunomodulating drugs. More recently, diagnostic criteria have been proposed for an unusual variant of CAA, probably related to an iatrogenic origin (iCAA), toward which there is mounting scientific interest. These atypical forms of CAA are still poorly known, and their recognition can be challenging and deserve to be pursued in specialized referral centres. The aim of this brief review is to focus current developments in the field of rare forms of CAA, its pathogenesis as well as clinical and biological features in order to increase awareness of these rare forms.

Angiopathy

Pathogenesis

10.3389/fnins.2023.1219025

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Citations (4)

Novel NOTCH3 mutation c.1564 T > A (p.Cys522Ser) presenting with early-onset Parkinsonism and white matter lesions

Clinical Parkinsonism & Related Disorders (2025)

Nicola Rifino Silvia Baratta Esteban Zacarias Isabella Canavero Benedetta Storti

CADASIL (Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy) is a hereditary small vessel disease caused by mutations in the NOTCH3 gene, characterized by recurrent strokes, cognitive decline, and psychiatric symptoms. This report presents a novel NOTCH3 c.1564 T > A (p.Cys522Ser) mutation associated with early-onset parkinsonism and significant white matter lesions. We describe a patient who presented with early-onset parkinsonism, characterized by bradykinesia and rigidity, alongside extensive white matter lesions observed through neuroimaging. Genetic testing revealed a novel c.1564 T > A (p.Cys522Ser) mutation in the NOTCH3 gene, contributing to the clinical diagnosis of CADASIL. This case underscores the phenotypic variability of CADASIL and the potential for atypical presentations, including parkinsonism. Early identification of genetic mutations can facilitate appropriate management and counseling for affected individuals and their families. Further research is warranted to explore the mechanisms underlying the association between NOTCH3 mutations and parkinsonism. Our findings contribute to the understanding of CADASIL, suggesting that clinicians should consider CADASIL in differential diagnoses of early-onset parkinsonism, especially in patients with concurrent white matter lesions.

White (mutation)

10.1016/j.prdoa.2025.100297

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Citations (0)

COVID‐19 provoking Guillain–Barré syndrome: The Bergamo case series

European Journal of Neurology (2020)

Camillo Foresti Maria Cristina Servalli Barbara Frigeni Nicola Rifino Benedetta Storti

The authors declare no financial or other conflicts of interest.

2019-20 coronavirus outbreak

10.1111/ene.14549

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Citations (15)

Iatrogenic cerebral amyloid angiopathy: An illustrative case of a newly introduced disease

European Journal of Neurology (2023)

Benedetta Storti Isabella Canavero Maria M. Gabriel Antonella Capozza Nicola Rifino

Iatrogenic cerebral amyloid angiopathy (iCAA) is a specific type of cerebral amyloid angiopathy which is becoming increasingly diagnosed. It has been hypothesized that iCAA might arise as a late consequence of past neurosurgical interventions involving dural patch grafts. Positron emission tomography (PET) scans with amyloid tracers and the assay of beta-amyloid levels in cerebrospinal fluid (CSF) are auxiliary criteria, however, definite diagnosis remains histopathologically determined.Case report.We present a 48-year-old patient who suffered multiple lobar cerebral haemorrhages from the age of 47. The patient had undergone surgery for remolval of hemangioblastoma with lyophilized dural graft at the age of 11, in 1987. Brain MRI, amiloid PET and CSF analysis led to a diagnosis of probable iCAA.It is necessary to increase the awareness of iCAA, in order to avoid overlooking the potential causal involvement of surgical procedures which took place far back in time. Moreover, the diagnostic relevance of amyloid PET and beta-amyloid levels in CSF must be emphasised.

Amyloid (mycology)

Angiopathy

10.1111/ene.15997

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Citations (7)

Unilateral axillary nerve palsy following birthing bar use

International Journal of Gynecology & Obstetrics (2020)

Lucio Tremolizzo Benedetta Storti Carlo Ferrarese Ildebrando Appollonio

Kneeling

Bar (unit)

Neuritis

10.1002/ijgo.13308

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Citations (2)