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10.1001/archotol.132.8.850-b

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Announcement

Digestion (1983)

Allen W. Mangel John R. Stavorski Robert G. Pendleton Jean Pirotte Dia El Allaf

10.1159/000198997

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Author Index, Vol. 28, 1983

Digestion (1983)

Allen W. Mangel John R. Stavorski Robert G. Pendleton Jean Pirotte D. El Allaf

10.1159/000198998

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Letters to the Editor

Digestion (1983)

Allen W. Mangel John R. Stavorski Robert G. Pendleton Jean Pirotte D. El Allaf

Sir, In their report on a patient with dihydral azine hepatitis, Pariente et al. [1] quoted 3 cases from the literature, claiming to present a 'review o f the literature'.They have failed, however, to mention at least 22 further cases reported by German authors.We have seen 2 patients [2], probably too recently to be noted by Pariente et al., but Roschlau et al. [3] and Roschlau [4] observed and published 20 cases o f dihydralazine hepatotoxicity.The purpose o f our letter is to draw the attention o f an international readership to these further reports which indicate a rather frequent com plication of dihydralazine therapy.

10.1159/000198996

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Ursodeoxycholic Acid for the Dissolution of Radiolucent Gall Bladder Stones

Digestion (1983)

P. Neligan M C Bateson D B Trash P E Ross I.A.D. Bouchier

In a prospective dosage response study of 84 patients with radiolucent gall bladder stones treated with ursodeoxycholic acid (UDCA), a dose of 500 mg daily was as effective as 1,000 mg daily. Complete dissolution of stones was achieved in 9 of 31 patients (29%) treated for at least 6 months with the lower dose, and in 7 of 33 patients (21%) on the higher dose. 4 patients in each group continue on treatment having shown partial gall-stone dissolution. When the two dosage groups were considered together, small stones dissolved more readily than larger ones and, after allowance for stone size, success rates were equal in obese and non-obese patients. Treatment with UDCA was well tolerated and significant adverse effects were not encountered.

Radiodensity

Ursodeoxycholic acid

10.1159/000198992

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