Beatriz Sobrino

Research Field

Cohen's kappa

Specialty

Kappa

10.1016/j.spinee.2015.10.006

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Citations (57)

Design, synthesis and validation of a new Crimped Head-Piece for DNA-Encoded libraries generation

Bioorganic & Medicinal Chemistry (2024)

Ramón Rama-Garda María Dolores Martín-Ortega Anthony de Jesús Sánchez Julián Priego Jesús de Blas

Codification of DNA Encoded Libraries (DELs) is critical for successful ligand identification of molecules that bind a protein of interest (POI). There are different encoding strategies that permit, for instance, the customization of a DEL for testing single or dual pharmacophores (single strand DNA) or for producing and screening large diversity libraries of small molecules (double strand DNA). Both approaches challenges, either from the synthetic and encoding point of view, or from the selection methodology to be utilized for the screening. The Head-Piece contains the DNA sequence that is attached to a chemical compound, allowing the encoding of each molecule with a unique DNA tag. Designing the Head-Piece for a DNA-encoded library involves careful consideration of several key aspects including DNA barcode identity, sequence length and attachment chemistry. Here we describe a double stranded DNA versatile Head-Piece that can be used for the generation of single or dual pharmacophore libraries, but also shows other advanced DEL functionalities, stability and enlarged encoding capacity.

Chemical space

10.1016/j.bmc.2024.117596

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Citations (1)

Streptococcal vertebral osteomyelitis: multiple faces of the same disease

Clinical Microbiology and Infection (2013)

Óscar Murillo Àlex Roset Beatriz Sobrino Jaime Lora-Tamayo R. Verdaguer

Viridans streptococci

Vertebral Osteomyelitis

Etiology

Streptococcus anginosus

10.1111/1469-0691.12302

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Citations (58)

New technologies in the genetic approach to sudden cardiac death in the young

Forensic Science International (2010)

Marı́a Brión Inés Quintela Beatriz Sobrino María Torres Catarina Allegue

Sudden Death

Genome-wide Association Study

10.1016/j.forsciint.2010.07.015

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Citations (24)

Whole-Blood DNA Methylation Analysis Reveals Respiratory Environmental Traits Involved in COVID-19 Severity Following SARS-CoV-2 Infection

medRxiv (Cold Spring Harbor Laboratory) (2021)

Guillermo Barturen Elena Carnero‐Montoro Manuel Martínez‐Bueno Silvia Rojo‐Rello Beatriz Sobrino

Abstract SARS-CoV-2 causes a severe inflammatory syndrome (COVID-19) leading, in many cases, to bilateral pneumonia, severe dyspnea and in ∼5% of these, death. DNA methylation is known to play an important role in the regulation of the immune processes behind COVID-19 progression, however it has not been studied in depth, yet. In this study, we aim to evaluate the implication of DNA methylation in COVID-19 progression by means of a genome-wide DNA methylation analysis combined with DNA genotyping. The results reveal the existence of epigenomic regulation of functional pathways associated with COVID-19 progression and mediated by genetic loci. We found an environmental trait-related signature that discriminates mild from severe cases, and regulates IL-6 expression via the transcription factor CEBP. The analyses suggest that an interaction between environmental contribution, genetics and epigenetics might be playing a role in triggering the cytokine storm described in the most severe cases.

Epigenomics

Cytokine Storm

10.1101/2021.11.03.21260184

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Citations (1)

Assessment of an educational intervention in the management of non-critical inpatient glycemic control

Acta Diabetologica (2013)

Ricardo Gómez‐Huelgas María D. López-Carmona Sergio Jansen‐Chaparro Beatriz Sobrino María G. Cháves

Regimen

Bolus (digestion)

Basal (medicine)

10.1007/s00592-013-0520-8