C Brambilla

University of Siena

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Sergio Giralt

Memorial Sloan Kettering Cancer Center

Miguel‐Angel Perales

Memorial Sloan Kettering Cancer Center

E Brambilla

Universidade de Caxias do Sul

Monica Bocchia

University of Siena

Kate A. Markey

Fred Hutch Cancer Center

M Coulomb

Hôpital Albert Michallon

Antonio L. C. Gomes

Memorial Sloan Kettering Cancer Center

Jonathan U. Peled

Cornell University

Sean M. Devlin

Memorial Sloan Kettering Cancer Center

Anqi Dai

Memorial Sloan Kettering Cancer Center

Cooperative Institutions

Memorial Sloan Kettering Cancer Center

Centre Hospitalier Universitaire de Grenoble

Université Grenoble Alpes

Kettering University

Istituti di Ricovero e Cura a Carattere Scientifico

Inserm

Hôpital Albert Michallon

Cornell University

University of Siena

Azienda Ospedaliera Universitaria Senese

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Consensus statements from the Second International Lung Cancer Molecular Biomarkers Workshop: A European strategy for developing lung cancer molecular diagnostics in high risk populations

International Journal of Oncology (2002)

John K. Field C Brambilla N Caporaso Antoine Flahault Claudia I. Henschke

The Second Molecular Biomarkers Workshop was held at the Roy Castle International Centre for Lung Cancer Research in Liverpool, in June 2001 and it brought together experts in the clinical, epidemiological and molecular-pathology of lung cancer from Europe and the USA, to address issues surrounding the development of a European strategy for early lung cancer detection. The 2001 Workshop Breakout Groups concentrated on the current challenges in the early detection of lung cancer which need to be addressed in the light of the recent surge in interest in many countries for mounting new clinical trials to evaluate the utility of Spiral CT in early lung cancer detection. If population-based trials of CT screening are mounted it will also be a favorable clinical environment in which to evaluate efficiently recent advances in molecular screening and genotyping. The Workshop focused specifically on: a) clinical and molecular biomarkers, b) sputum as an early detection and diagnostic tool, c) validation of molecular markers prior to their use in early detection trials and d) ethical issues that have to be considered in early lung cancer detection trials. A distillation of the Workshop discussions is given in this article.

Molecular diagnostics

Molecular biomarkers

10.3892/ijo.21.2.369

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Citations (22)

Intensification Of Treosulfan and Fludarabine-Based Conditioning With 4 Gy TBI For Allogeneic Stem Cell Transplantation In Patients With Hematological Malignancies

Blood (2013)

Fabio Giglio C Brambilla Francesca Lorentino Simona Piemontese Lara Crucitti

Treosulfan

Regimen

Cumulative incidence

10.1182/blood.v122.21.2149.2149

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Citations (0)

[Right to left shunts in the adult].

PubMed (1994)

C Billon C Brambilla B Paramelle

Hepatopulmonary syndrome

Right-to-left shunt

Hypoxia

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Citations (1)

[Lymphomatoid granulomatosis. Preliminary study of a case with pulmonary and central nervous system involvement (author's transl)].

PubMed (1979)

B Pasquier P Couderc Dominique Pasquier A N'Golet Panh Mh

Lymphomatoid granulomatosis

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[Respiratory distress with rapidly favorable course].

PubMed (1994)

E Arbib C Brambilla

Course (navigation)

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[Transparietal needle biopsy of pulmonary lesions with an image intensification system. Apropos of 82 biopsies].

PubMed (1987)

F Blanc-Jouvan F Paillasson B. Aguilaniu Phillip D. Levy E Brambilla

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Unusual cystic presentation of pulmonary nodular amyloidosis associated with MALT-type lymphoma

European Respiratory Journal (2007)

Sylvie Lantuéjoul Nabila Moulaï S. Quétant P Y Brichon C Brambilla

The case reported herein consists of nodular pulmonary amyloidosis presenting with unusual cystic radiological features which reveal a pulmonary localisation of an extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma). The present case is the first to report a radiological presentation of nodular pulmonary amyloidosis in the absence of Sjögren's syndrome. Although transthoracic fine-needle biopsy was helpful for the diagnostic of amyloidosis, final diagnosis of associated MALT-type lymphoma required an open lung biopsy. This emphasises the importance of performing surgical investigations in pulmonary nodular amyloidosis in order to depict the presence of underlying lung tumours or lymphoproliferative disorders.

Mucosa-associated lymphoid tissue

10.1183/09031936.00136605

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Citations (55)

Valeur de la tomodensitométrie haute résolution dans l'histiocytose X pulmonaire. Corrélations radiocliniques et fonctionnelles.

Revue des Maladies Respiratoires (1992)

É. Kelkel C. Pison E Brambilla G. Ferreti M Coulomb

DLCO

High-resolution computed tomography

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Citations (2)

Combination chemotherapy with adriamycin (NSC-123127) in metastatic mammary carcinoma.

PubMed (1974)

C Brambilla De Lena M Gianni Bonadonna

Mammary carcinoma

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Citations (15)

Analysis of p53 antibody response in patients with squamous cell carcinoma of the head and neck.

PubMed (1996)

Jean‐Pierre Lavieille Richard Lubin Thierry Soussi É. Reyt C Brambilla

p53 alterations are the most common alteration found in human cancer. Protein p53 was studied in 102 patients with early lesions or advanced squamous cell carcinoma of the head and neck (SCCHN). Biopsies and sera samples were collected before the initiation of treatment. Protein p53 expression was evaluated by immunohistochemistry using Pab 1801, Pab 240, DO7 and CM1 antibodies on paraffin-embedded sections. Antibodies specific for p53 protein were analysed in the sera of these patients by an ELISA procedure. We demonstrated that p53 protein overexpression (> or = 20% positive cells) was an early event in the carcinogenesis of SSCHN and correlated to the progression of carcinogenesis. Overexpression of protein p53 was frequent (56.5%) in advanced tumors. No correlation was found with clinical stage or the differentiation status of the tumor, but we demonstrated differences in protein p53 expression according to the initial localisation of the tumor, with high expression in hypopharynx (67%) and oropharynx (65%) versus larynx (12%). The prevalence of p53 antibodies was high (44%) and was correlated with the rate of p53 overexpression (> or = 30% positive cells) in tumors (p < 0.0001 chi square test). These results suggest that the humoral response is an indicator of the presence of squamous cell carcinoma with immunogenic mutant p53 protein. Therefore the detection of anti-p53 antibodies could be used as a precocuous marker of p53 alteration and a prognostic marker, in order to screen for patients with a better prognosis.

Epidermoid carcinoma

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Citations (23)