R. F. Fedortseva

Research Field

Breakpoint

10.1134/s1990519x08040135

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Citations (2)

[Cytogenetic study of acute leukemia and the influence of 6-mercaptopurine on the chromosomes of the blood cells].

PubMed (1976)

V P Dygin Iu L Goroshchenko R. F. Fedortseva S E Mamaeva

Mercaptopurine

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Ядерные аномалии соматических клеток как универсальные индикаторы воздействия ионизирующего излучения

Садашивам Анбумани Александра Андреевна Ливанова R. F. Fedortseva

Results and Discussion. The specific effect of ionizing radiation, observed in somatic cells of different organisms, is double-strand DNA breaks with the subsequent formation of chromosomal aberrations of unstable type. These aberrations are followed be the appearance of several types of nuclear anomalies in the interphase of the cell cycle. Among such anomalies, micronuclei, «tailed» nuclei, nucleoplasmic bridges, and also dumbbell-formed nuclei are distinguished. In the review, these types of karyopathology and the underlying molecular mechanisms are described in detail, and literature data describing these anomalies in different organisms are given. The detection of nuclear anomalies in somatic cells not only of humans, but also of plants and animals, allows us to conclude that these changes in the structure of the nucleus are universal markers of ionizing radiation effect. Conclusion. The use of a set of these types of karyopathology as radio-specific biomarkers seems promising for the creation of a universal protocol of a biodosimetric test for a comprehensive assessment of the state of natural ecosystems and human health in conditions of radiation contamination.

Interphase

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[Nuclei with protrusions--"tailed" nuclei--and radiation cytogenetic markers in a lymphocyte culture after x-ray irradiation].

PubMed (2000)

А. М. Никифоров R. F. Fedortseva E K Monosova N M Iartseva V. I. Kravtsov

Frequency of the appearance of binuclear cells with nuclei having outgrowth into the cytoplasmic space and arise after first mitosis in human lymphocyte culture is linear-square dependent on the X-irradiation at doses from 0.0 to 4.0 Gy. Positive correlation between frequency of cells with "tailed" nuclei and frequency of metaphases of first mitosis having dicentrics and rings was established. Apparently, formation such "tailed" nuclei is connected with dicentrics and rings.

Mitotic index

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Citations (4)

Peculiar cellular mechanisms of effects of the low-dose ionizing radiation

R. F. Fedortseva R.P. Stepanov P.V. Antonov А. М. Никифоров I.B. Bychkovskaya

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Unusual long-lasting effects induced by low doses of radiation: electron microscopy studies of endothelium of rat myocardium capillaries

International Journal of Low Radiation (2006)

R. F. Fedortseva R.P. Stepanov Irina B. Bychkovskaya

An attempt is made to substantiate experimentally the pathophysiological mechanism of disturbance in relatively radio-resistant tissues (myocardial capillary endothelium of rats) after X-ray irradiation at low doses comparable with doses to liquidators of the Chernobyl accident. It has been found that the X-ray radiation at a dose of 0.5 Gy induces long-lasting potential alterations in rat myocardial capillary endothelial cells, in the form of an increase in the yield of cells with different signs of cytoplasmic damage. The observed effect does not depend on the dose, ranging from 0.5 to 4.5 Gy, and appears during the most of an animal's life. Dynamic observations have shown the absence of reparative changes in the damaged cells. It is suggested that the detected changes might play a significant role in the development of non-stochastic, low-dose radiation effects (including post-accident situations).

Pathophysiology

10.1504/ijlr.2006.010005

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Citations (2)

Study of DNA integrity in somatic cells and spermatozoa by single-cell gel electrophoresis with silver-nitrate staining

Cell and Tissue Biology (2008)

С. Н. Прошин G. V. Stepanov V. Yu. Kravtsov G. P. Kosyakova I. A. Paranyan

Microelectrophoresis

Silver stain

Silver nitrate

10.1134/s1990519x08010136

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