Kazumasa Yamada

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Lack of Any Positive Effect of Intestinal Metaplasia on Induction of Gastric Tumors in Wistar Rats Treated with N‐Methyl‐N‐nitrosourea in Their Drinking Water

Japanese Journal of Cancer Research (1994)

Hiromitsu Watanabe Yukio Ando Kazumasa Yamada Taro Okamoto Akihiro Ito

The influence of intestinal metaplasia on gastric cancer induction was examined in five-week-old male Wistar:Crj rats. The animals were first treated with two 10 Gy doses of X-rays to the gastric region at a 3-day interval (total 20 Gy) and then, starting two months after the irradiation, received 100 ppm N-methyl-N-nitrosourea (MNU) in their drinking water for 15 weeks. Thereafter they were maintained for 37 weeks with or without a dietary 1% sodium chloride (NaCl) supplement. The incidences of gastric adenocarcinomas in the MNU or MNU plus NaCl groups were significantly higher than in animals receiving X-rays plus MNU with or without NaCl. Intestinal metaplasias and the numbers of alkaline phosphatase (ALP)-positive foci were significantly increased in the X-ray irradiation groups but the numbers of ALP-positive foci were not increased with or without 1% NaCl. An inverse relationship between incidences of gastric tumors and intestinal metaplasias was apparent. The present experiment thus showed that the presence of intestinal metaplasia does not exert a positive influence on induction of gastric neoplasia by MNU in the rat.

Intestinal metaplasia

Metaplasia

Gastric tumor

10.1111/j.1349-7006.1994.tb02965.x

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Citations (16)

P3.01-34 Short Hydration Regimen with a Modified Dose of Magnesium Supplementation for Lung Cancer Patients Receiving Cisplatin-Based Chemotherapy

Journal of Thoracic Oncology (2018)

Tetsunari Hase Makoto Miyazaki Kazuya Ichikawa Naoyuki Yogo Naoya Ozawa

Regimen

Nephrotoxicity

Chemotherapy regimen

10.1016/j.jtho.2018.08.1594

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Citations (0)

Influence of Postural Control and Cognitive Functions on Care-level

Rigakuryoho Kagaku (2018)

Kazumasa Yamada Takumi Otake Daisuke Kimura

〔目的〕身体バランス機能および認知機能が要介護度に与える影響について検討した．〔対象と方法〕通所リハビリテーションサービス利用者107名を要介護度で3群に分類した．身体バランス機能と認知機能を評価し，重回帰分析と群間比較を行った．〔結果〕要介護度は身体バランス機能と認知機能とも影響していた．身体バランス機能は要支援群と要介護軽度群，要支援群と要介護中等度群で，認知機能は要支援群と要介護中等度群，軽度要介護群と要介護中等度群で有意差を認めた．〔結語〕身体バランス機能と認知機能はともに要介護度に影響を与えており，介護の悪化は身体バランス機能が認知機能に先んじて低下することが示唆された．

10.1589/rika.33.421

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Citations (1)

Elevated Serum Growth Hormone Accelerates Gastric Tumorigenesis in F344 Rats after Treatment with N‐Methyl‐N‐nitrosourea in Their Drinking Water

Japanese Journal of Cancer Research (1995)

Hiromitsu Watanabe Nariaki Fujimoto Keiichi Kawamoto Yukio Ando Kazumasa Yamada

We examined the effects of growth hormone on tumorigenesis in F344 rats treated with N ‐methyl‐ N ‐nitrosourea (MNU). Four‐week‐old male F344 rats were exposed to 100 ppm MNU in their drinking water for 15 weeks. Thereafter Group II animals received 100 μCi/100 g body weight of 131 I (radiothyroidectomy, Tx) injected i.p. and Group III rats were implanted with pituitary tumors (MtT) secreting growth hormone while Group I received no further treatment after MNU. Non‐carcinogen control animals received MtT, Tx or no treatment. Animals were killed at 39 weeks after starting MNU administration. Gastric tumors were present in 13 of 31 (43%), 15 of 32 (47%) and 17 of 32 (53%) rats in Groups I to III, respectively. All tumors were of well‐differentiated type. Spinal cord tumors appeared in 15 of 31 (47%) in Group I, 10 of 32 (32%) in Group II and 10 of 32 (32%) in Group III, most being malignant schwannomas. Thymic lymphornas also appeared in 10 of 31 (32%), 5 of 32 (16%) and 6 of 32 (19%) animals in Groups I to III, respectively. There were no significant differences among the groups. However, tumors in Group III developed significantly earlier than in Groups I or II. This was mainly due to gastric tumors, and cumulative incidence curves for spinal cord tumors or thymic lymphomas were similar in all groups. The results indicate that gastric tumors induced by MNU in F344 male rats are influenced by elevated levels of growth hormone.

Nitrosourea

10.1111/j.1349-7006.1995.tb02445.x

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Citations (4)

Occurrence of hypertension and nephropathy in rats exposed to tritiated water (HTO) as infants (2^ report)

Journal of Radiation Research (1999)

Akihiro Ito Kazumasa Yamada Tamaki Nakatani Hong Yin Nariaki Fujimoto

Tritiated water

Source

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Citations (0)

Influence of Paternal ²⁵²Cf Neutron Exposure on Abnormal Sperm, Embryonal Lethality, and Liver Tumorigenesis in the F₁ Offspring of Mice

Japanese Journal of Cancer Research (1996)

Hiromitsu Watanabe Tadateru Takahashi Juing‐Yi LEE Megu Ohtaki Goutam Roy

Experiments were conducted to determine whether neutron‐induced genetic damage in parental germline cells can lead to the development of cancer in the offspring. Seven‐week‐old C3H male mice were irradiated with 252 Cf neutrons at a dose of 0, 50, 100, or 200 cGy. Two weeks or 3 months after irradiation, the male mice were mated with virgin 9‐week‐old C57BL females. Two weeks after irradiation, the irradiated male mice showed an increased incidence of sperm abnormalities, which led to embryo lethalities in a dose‐dependent manner when they were mated with unirradiated female mice. Furthermore, liver tumors in male offspring of male mice in the 50 cGy group were significantly increased in 19 of 44 (43.2%) animals, in clear contrast to the unirradiated group (1 of 31; 3.2%) ( P < 0.01). In the 100 cGy group, 6 of 39 (15%) mice had lesions. At 3 months after irradiation abnormal sperm and embryonal lethality were not significantly increased. The incidences of liver tumors in male offspring from the 50 cGy, 100 cGy and 200 cGy groups were 6 of 20 (30%), 5 of 22 (23%) and 1 of 19 (5%), respectively, which are not significantly increased compared with the control. It is concluded that increased hepatic tumor risk in the F 1 generation may be caused by genetic transmission of hepatoma‐associated trait(s) induced by 252 Cf neutron irradiation.

Ratón

10.1111/j.1349-7006.1996.tb00199.x

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Citations (15)

SEPTICEMIA IN PATIENTS WITH ACUTE LEUKEMIA AND RESULT OF ITS TREATMENT

Nihon Naika Gakkai Zasshi (1978)

Ryuzo Ohno Kohji Ezaki Yukio Kato Eiji Watanabe Yasuo Morishima

1969年より1977年までの9年間に名古屋大学第一内科および愛知県職員病院内科に入院した成人急性白血病患者179例に合併した48症例延54例の敗血症を対象とし,起炎菌の種類ならびに抗生物質療法の効果を中心に検討した.起炎菌はE. coli15例, Pseudomonas aeruginosa 12例, Pseudomonas sp. 2例, Klebsiella pneumoniae 6例, Serratia marcescens 5例, Aeromonas hydrophila 4例, Acinetobacter anitratus 3例等グラム陰性桿菌が計51例で全体の89.5%を占めた.グラム陽性菌はStaph. aureusの1例のみであり,嫌気性菌が2例,真菌が3例みられた.発症時の末梢血成熟好中球数は0であつたもの19例を含み,中央値で40/cmmであつた.これらの高度の顆粒球減少状態にある敗血症に対しcarbenicillin, sulbenicillin, cephalothin, cefazolin, gentamicin, dibekacin, amikacinを中心とする抗生物質の大量併用療法を試みた所,白血病治療開始前に発症した4例中全例,初回寛解導入期に発症した22例中18例,再発寛解導入期の5例中4例,強化療法期の1例中1例,計32例中27例(84.4%)が治療可能であつたのに比し,終末増悪期に発生した22例中治癒したのは6例のみで, 16例は死亡した. 54例中27例はショック状態におちいつたが,内15例は治癒可能であり,このような重篤な敗血症でも,抗生物質大量併用投与,白血球輸血等の積極的な治療により充分治癒可能であると考えられる.

Carbenicillin

Amikacin

Cefazolin

10.2169/naika.67.1384

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Accumulation of products of lipid peroxidation in spontaneous liver tumors of C3H/HeN mice

Oncology Reports (1996)

Kazumasa Yamada Hirohisa Watanabe Takehiko Gotoh Georgi. N. Kanin Akihiro Ito

Thiobarbituric acid

Lipid peroxide

10.3892/or.3.5.835

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Citations (1)

Effect of balance exercise in combination with whole-body vibration on muscle activity of the stepping limb during a forward fall in older women: A randomized controlled pilot study

Archives of Gerontology and Geriatrics (2014)

Akira Ochi Tomokazu Abe Kazumasa Yamada Satoko Ibuki Hiroshige Tateuchi

Whole body vibration

Balance Test

10.1016/j.archger.2014.11.011

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Citations (16)

High‐grade tumor‐specific immunity induced by L1210 leukemia variants obtained from the culture of L1210 cells fused with Lesch‐Nyhan fibroblasts

International Journal of Cancer (1983)

Kohei Kawashima E Nagura Eiji Watanabe K. Mizoguchi S Saga

Abstract A highly immunogenic variant of the murine L1210 leukemia cell (L1210/LN‐1) for generation of tumor immunity has been obtained from culture of L1210 cells originally fused with human Lesch‐Nyhan fibroblasts. In L1210/LN‐1 cells, no human chromosomes were identified and chromosomes Ml and No. I carried by the parent L1210 cells were missing. L1210/LN‐1 cells displayed an intermediate morphology between L1210 cells and Lesch‐Nyhan fibroblasts. Most of the CDF 1 mice that were inoculated with less than 2 × 10 6 L1210/LN‐1 cells survived over 60 days without evidence of tumor, whereas the original L1210 cells killed all the mice tested in about 2 weeks. When inoculated with more than 5 × 10 6 L1210/LN‐1 cells, CDF 1 mice developed tumor. The CDF 1 mice which rejeted 2 × 10 6 L1210/LN‐1 cells were protected very effectively against challenge of otherwise highly aggressive 1–5 × 10 5 L1210 leukemia cells; 40 out of 43 primed mice tested survived for 60 days or longer after the tumor challenge. Even the CDF 1 mice primed with irradiated or mitomycin‐treated L1210/LN‐1 cells survived against a challenge of 10 s L1210 leukemia cells. They were, however, not protected against P388 leukemia or Meth A sarcoma, indicating that the immunity was specific to L1210 leukemia. The immunity induced by L1210/LN‐1 cells was transplantable by immune spleen cells into syngeneic recipients. Thus, the L1210/LN‐1 cells we obtained seem to be very useful as an immunogen for generation of high‐grade tumor‐specific immunity against highly malignant L1210 leukemia.

L1210 cells

Neoplasm

10.1002/ijc.2910320419

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Citations (8)