Tamàs Fülöp

Université de Sherbrooke

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Co-Authors

Anis Larbi

Singapore Immunology Network

141

Abdelouahed Khalil

Université de Sherbrooke

Jacek M. Witkowski

Gdańsk Medical University

Graham Pawelec

University of Tübingen

Gilles Dupuis

Université de Sherbrooke

Alan A. Cohen

Columbia University

Carl Fortin

University of Michigan–Ann Arbor

Aurélie Le Page

Université de Sherbrooke

Christian Bocti

Université de Sherbrooke

ÉF

Éric Frost

Université de Sherbrooke

Cooperative Institutions

Université de Sherbrooke

221

Inserm

130

Centre National de la Recherche Scientifique

Centre Hospitalier Universitaire de Sherbrooke

University of Cambridge

University of Bristol

University College London

National University of Singapore

University of Toronto

Health and Social Services Centre University Institute of Geriatrics of Sherbrooke

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On the Immunological Theory of Aging

Interdisciplinary topics in gerontology and geriatrics (2014)

Tamàs Fülöp Jacek M. Witkowski Graham Pawelec Alan A. Cohen Anis Larbi

Aging is a complex phenomenon the cause of which is not fully understood, despite the plethora of theories proposed to explain it. As we age, changes in essentially all physiological functions, including immunity, are apparent. Immune responses decrease with aging, contributing to the increased incidence of different chronic diseases with an inflammatory component (sometimes referred to as 'inflamm-aging'). It is clear from many studies that human longevity may be influenced by these changes in the immune system, but how they proceed is not clearly determined. In this chapter, we will review the age-related changes in the immune response and assess the validity of the immune theory of aging (i.e. that these changes in immune response are the primary cause of aging). Many data in humans support the notion that age-associated immune dysfunction may at least in part explain the aging process. Explanatory power may be enhanced by combination with other theories such as the free radical theory. More longitudinal studies are needed to corroborate the immune theory of aging.

Immunosenescence

Explanatory power

10.1159/000358904

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Citations (152)

Age-Related Alterations in PON1

Springer eBooks (2007)

I. Serés Tamás Fülöp G. Paragh Abdelouahed Khalil

Paraoxonase

Aryldialkylphosphatase

High-density lipoprotein

Low-density lipoprotein

10.1007/978-1-4020-6561-3_13

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Citations (2)

The Fuzzy Border between the Functional and Dysfunctional Effects of Beta-Amyloid: A Synaptocentric View of Neuron–Glia Entanglement

Biomedicines (2023)

Francesca Fagiani Tamás Fülöp Stefano Govoni Cristina Lanni

Recent observations from clinical trials using monoclonal antibodies against Aβ seem to suggest that Aβ-targeting is modestly effective and not sufficiently based on an effective challenge of the role of Aβ from physiological to pathological. After an accelerated approval procedure for aducanumab, and more recently lecanemab, their efficacy and safety remain to be fully defined despite previous attempts with various monoclonal antibodies, and both academic institutions and pharmaceutical companies are actively searching for novel treatments. Aβ needs to be clarified further in a more complicated context, taking into account both its accumulation and its biological functions during the course of the disease. In this review, we discuss the border between activities affecting early, potentially reversible dysfunctions of the synapse and events trespassing the threshold of inflammatory, self-sustaining glial activation, leading to irreversible damage. We detail a clear understanding of the biological mechanisms underlying the derangement from function to dysfunction and the switch of the of Aβ role from physiological to pathological. A picture is emerging where the optimal therapeutic strategy against AD should involve a number of allied molecular processes, displaying efficacy not only in reducing the well-known AD pathogenesis players, such as Aβ or neuroinflammation, but also in preventing their adverse effects.

Dysfunctional family

Amyloid (mycology)

Amyloid beta

10.3390/biomedicines11020484

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Citations (0)

Discovering Secondary Protein Structures via Local Euler Curvature

bioRxiv (Cold Spring Harbor Laboratory) (2023)

Rodrigo A. Moreira Róisín Braddell Fernando A. N. Santos Tamás Fülöp Mathieu Desroches

Protein structure analysis and classification, which is fundamental for predicting protein function, still poses formidable challenges in the fields of molecular biology, mathematics, physics and computer science. In the present work we exploit recent advances in computational topology to define a new intrinsic unsupervised topological fingerprint for proteins. These fingerprints, computed via Local Euler Curvature (LECs), identify secondary protein structures, such as Helices and Sheets, by capturing their distinctive topological signatures. Using an extensive protein residue database, the proposed computational framework not only distinguishes between structural classes via unsupervised clustering but also achieves remarkable accuracy in classifying proteins structures through supervised machine learning classifier. We also show that the internal structure of LEC space embeds the information about the secondary structure of proteins. Beyond its immediate implications for the advancement of critical application areas such as drug design and biotechnology, our approach opens a fascinating avenue towards characterizing the multiscale structures of diverse biopolymers based solely on their geometric and topological attributes.

Euler characteristic

Topological data analysis

10.1101/2023.11.27.568841

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Technetium-99m sestamibi scintigraphy for the assessment of lower extremity ischaemia in peripheral arterial disease

European Journal of Nuclear Medicine (1994)

László Bajnok B Kozlovszky József Varga J Antalffy Sándor Olvasztó

Hyperaemia

Technetium (99mTc) sestamibi

Dipyridamole

Technetium-99m

10.1007/bf02426697

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Citations (26)

Cytokine receptor signalling and aging

Mechanisms of Ageing and Development (2006)

Tamás Fülöp Anis Larbi Nadine Douziech I. Levesque Audrey Varin

Immunosenescence

Signalling

Immune receptor

10.1016/j.mad.2006.01.025

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Citations (101)

Transmembrane Signaling Changes with Aging^a

Annals of the New York Academy of Sciences (1992)

Tamàs Fülöp György Barabás Zsolt Varga J. Csongor Markus Hauck

Altered immune response and transmembrane signaling with aging has previously been demonstrated. The aim of the present study was to characterize PMNLs and lymphocyte G proteins and to determine whether their relative amounts are altered with aging. First we studied the effects of FMLP on PMNLs IP3 formation. It was found that in any group of elderly the PMNLs IP3 formation was significantly decreased compared to that of young subjects. In FMLP receptor binding affinity no measurable difference exists in either low- or high-affinity FMLP receptors. The autoradiogram of 32P-ADP-ribosylated proteins by CT in lymphocytes of young individuals showed a major polypeptide of 40 kDa, and two much less prevalent components of 52 and 45 kDa. In contrast, in lymphocytes of elderly subjects the major polypeptide was 45 kDa, and the two others were very weakly labeled. In PMNLs, CT labeled the 45-kDa band quite strongly, mainly in the elderly, and the 52- and 40-kDa bands were very weakly labeled, mainly in young subjects. When PT was used, no age-related pattern changes could be demonstrated, while differences could be observed between the two types of cells.

10.1111/j.1749-6632.1992.tb27449.x

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Citations (27)

Aging and malignant hemopathies

Haematologica (2015)

Dominique Bron Lionel Adès Tamás Fülöp Valentin Goede

improve the classification of the disease and will lead to therapeutic biomarkers.In fact, there is a clinical need to extend our current limited therapeutic portfolio by the detection of innovative therapeutic targets. 20 In the interest of our patients, we hope that these efforts will extend our therapeutic armamentarium in the near future and will offer truly personalized approaches.

Plenary session

10.3324/haematol.2014.117721

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Citations (8)

Aging, frailty and age-related diseases

Biogerontology (2010)

Tamàs Fülöp Anis Larbi Jacek M. Witkowski Janet E. McElhaney Mark Loeb

Stressor

Vulnerability

Cognitive Decline

Frailty syndrome

10.1007/s10522-010-9287-2