Eugene Braunwald

Brigham and Women's Hospital

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Co-Authors

Andrew G. Morrow

Edward Via College of Osteopathic Medicine

John Ross

Washington University in St. Louis

Dean T. Mason

University of California, Davis

Edmund H. Sonnenblick

National Heart Lung and Blood Institute

Marc S. Sabatine

Thrombolysis in Myocardial Infarction Study Group

Sabina A. Murphy

Brigham and Women's Hospital

Elliott M. Antman

Brigham and Women's Hospital

David A. Morrow

Brigham and Women's Hospital

Adrian F. Hernandez

Clinical Research Institute

Charles A. Chidsey

University of Colorado Boulder

Cooperative Institutions

Advisory Board Company (United States)

514

Palo Alto Institute

498

Harvard University

280

Brigham and Women's Hospital

258

Johns Hopkins University

177

University of Washington

176

Washington University in St. Louis

154

National Heart Lung and Blood Institute

132

St. Louis County Missouri

124

National Institutes of Health

117

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Effects of Reserpine and Guanethidine on Venous Reflexes

Circulation Research (1962)

Thomas E. Gaffney Willow Bryant Eugene Braunwald

The effects of reserpine and guanethidine on reflex venoconstriction were studied in a group of open-chest anesthetized dogs by the major vessel occlusion technique described by Bartelstone. Guanethidine (10 mg./Kg. intravenously) blocked reflex venous constriction following carotid occlusion and central vagal stimulation within, five minutes after injection in five dogs. Reserpine (0.5 mg./Kg. intravenously) required 50 to 110 minutes to abolish these venopressor reflexes in five animals. Pretreatment with either reserpine (0.5 mg./Kg. intraperitoneally on two consecutive days in four dogs) or guanethidine (10 mg./Kg. intravenously on two days in four dogs) also abolished reflex venoconstriction. These results indicate that reserpine and guanethidine are capable of blocking reflex venoconstriction, and it is suggested that this action may contribute to their effects in the treatment of hypertension.

Guanethidine

Reserpine

Constriction

10.1161/01.res.11.5.889

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Citations (26)

Noninvasive Detection of Vulnerable Coronary Plaques

Journal of the American College of Cardiology (2009)

Eugene Braunwald

10.1016/j.jacc.2009.03.040

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Citations (37)

Invited Commentary

Journal of Cardiac Surgery (1994)

Eugene Braunwald

10.1111/j.1540-8191.1994.tb00928.x

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AN ANALYSIS OF THE DETERMINANTS OF VENTRICULAR DIMENSIONS AND FORCE-VELOCITY RELATIONS IN MAN

University of California Press eBooks (2023)

Eugene Braunwald

10.2307/jj.8501083.22

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PANEL DISCUSSION

University of California Press eBooks (2023)

H.J.C. Swan Eugene Braunwald Paul G. Hugenholtz Madison S. Spach

10.2307/jj.8501083.24

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Mitral Regurgitation

New England Journal of Medicine (1969)

Eugene Braunwald

IT may be thought curious that I have chosen mitral regurgitation (MR), often considered the simplest of the cardiac valvular lesions, as the subject of this lecture. Of all valvular lesions, rheumatic MR is the one that could probably be recognized most easily by the beginning medical student, since the characteristic systolic murmur is so readily detected. My own interest in the subject began during medical school, when I became aware of the controversy surrounding the interpretation of systolic heart murmurs in children with a history of rheumatic fever. In the 1920's and 1930's it was considered by some that . . .

Heart murmur

Valvular Regurgitation

10.1056/nejm196908212810807

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Citations (130)

Catecholamine excretion and cardiac stores of norepinephrine in congestive heart failure

The American Journal of Medicine (1965)

Charles A. Chidsey Eugene Braunwald Andrew G. Morrow

Sympathetic nervous system

10.1016/0002-9343(65)90211-1

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Citations (573)

Cardiovascular Medicine at the Turn of the Millennium: Triumphs, Concerns, and Opportunities

New England Journal of Medicine (1997)

Eugene Braunwald

Tthe end of every century it is customary to reflect on the events of the past hundred years and to look toward the future, and in this lecture I should like to do this for cardiovascular disease. This is also an especially opportune time to comment on progress in cardiovascular disease, because both the National Heart, Lung, and Blood Institute and the American Heart Association are celebrating their golden anniversaries within the next 18 months. These two organizations have had the most profound influence on the development of research on cardiovascular disease during the 20th century. A bewildering amount of . . .

10.1056/nejm199711063371906

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Citations (1,444)

[SURGICAL TREATMENT OF AORTIC STENOSIS WITH VALVULAR CALCIFICATION].

PubMed (1964)

Morrow Ag Bender Gv Osten Vg Eugene Braunwald

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Calcific Pulmonic Stenosis

Circulation (1968)

William C. Roberts Dean T. Mason Andrew G. Morrow Eugene Braunwald

Seven patients are described in whom calcium deposits occurred in stenotic pulmonary valves. In five the calcific deposits were visible on chest roentgenogram. Survival into adulthood and severe pulmonic stenosis appeared to be the prerequisites for the development of large deposits of calcium in this valve.

Pulmonic stenosis

Pulmonary valve stenosis

10.1161/01.cir.37.6.973

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Citations (36)