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Neha Waghmare

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Arun Chandru

Biotech Park

Suvro Kanti Chowdhury

Biotech Park

Tuhin Bhowmick

Indian Institute of Science Bangalore

Parinita Agrawal

National Institute of Technology Rourkela

Veena Sangwan

Dr. Shroff’s Charity Eye Hospital

Kamalnath Selvakumar

Biotech Park

Abha Gour

Dr. Shroff’s Charity Eye Hospital

Utkarsh Bhutani

Indian Institute of Technology Hyderabad

Anil Tiwari

Dr. Shroff’s Charity Eye Hospital

Bharti Sangwan

Dr. Shroff’s Charity Eye Hospital

Cooperative Institutions

Biotech Park

Dr. Shroff’s Charity Eye Hospital

Indian Institute of Technology Kanpur

Amity University

Christie's

Post Graduate Institute of Medical Education and Research

Indian Institute of Technology Delhi

Creative Commons

Indian Institute of Science Bangalore

Indian Institute of Technology Guwahati

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Sulfated polysaccharide mediated TGF-β1 presentation in pre-formed injectable scaffolds for cartilage tissue engineering

Carbohydrate Polymers (2018)

Neha Waghmare Aditya Arora Arijit Bhattacharjee Dhirendra S. Katti

Chondrogenesis

Gelatin

10.1016/j.carbpol.2018.03.091

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Citations (33)

Biopolymeric corneal lenticules by digital light processing based bioprinting: a dynamic substitute for corneal transplant

Biomedical Materials (2024)

Utkarsh Bhutani Namit Dey Suvro Kanti Chowdhury Neha Waghmare Rita Das Mahapatra

Digital light processing (DLP) technology has gained significant attention for its ability to construct intricate structures for various applications in tissue modeling and regeneration. In this study, we aimed to design corneal lenticules using DLP bioprinting technology, utilizing dual network bioinks to mimic the characteristics of the human cornea. The bioink was prepared using methacrylated hyaluronic acid and methacrylated gelatin, where ruthenium salt and sodium persulfate were included for mediating photo-crosslinking while tartrazine was used as a photoabsorber. The bioprinted lenticules were optically transparent (85.45% ± 0.14%), exhibited adhesive strength (58.67 ± 17.5 kPa), and compressive modulus (535.42 ± 29.05 kPa) sufficient for supporting corneal tissue integration and regeneration. Puncture resistance tests and drag force analysis further confirmed the excellent mechanical performance of the lenticules enabling their application as potential corneal implants. Additionally, the lenticules demonstrated outstanding support for re-epithelialization and stromal regeneration when assessed with human corneal stromal cells. We generated implant ready corneal lenticules while optimizing bioink and bioprinting parameters, providing valuable solution for individuals suffering from various corneal defects and waiting for corneal transplants.

3D bioprinting

Corneal Transplant

10.1088/1748-605x/ad3312

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Kuragel: A biomimetic hydrogel scaffold designed to promote corneal regeneration

iScience (2024)

Parinita Agrawal Anil Tiwari Suvro Kanti Chowdhury Mehak Vohra Abha Gour

Cornea-related injuries are the most common cause of blindness worldwide. Transplantation remains the primary approach for addressing corneal blindness, though the demand for donor corneas outmatches the supply by millions. Tissue adhesives employed to seal corneal wounds have shown inefficient healing and incomplete vision restoration. We have developed a biodegradable hydrogel - Kuragel, with the ability to promote corneal regeneration. Functionalized gelatin and hyaluronic acid form photo-crosslinkable hydrogel with transparency and compressive modulus similar to healthy human cornea. Kuragel composition was tuned to achieve sufficient adhesive strength for sutureless integration to host tissue, with minimal swelling post-administration. Studies in the New Zealand rabbit mechanical injury model affecting corneal epithelium and stroma demonstrate that Kuragel efficiently promotes re-epithelialization within 1 month of administration, while stroma and sub-basal nerve plexus regenerate within 3 months. We propose Kuragel as a regenerative treatment for patients suffering from corneal defects including thinning, by restoration of transparency and thickness.

10.1016/j.isci.2024.109641

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Print me a cornea - Are we there yet?

Bioprinting (2022)

Midhun Ben Thomas Shivaram Selvam Parinita Agrawal Prayag Bellur Neha Waghmare

Biofabrication

Corneal Diseases

10.1016/j.bprint.2022.e00227

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Citations (4)