Jackson S. Henneveld

Research Field

Covering: 2009 to 2022The Stemona alkaloids, which are found in plant species from the family Stemonaceae, represent a tremendously large and structurally-diverse family of natural products. This review presents and discusses a selection of case studies, grouped by alkaloid class, that showcase the key strategies and overall progress that has been made in the synthesis of Stemona alkaloids and related compounds since 2009. Structural reassignments that have been reported over this period are also identified where necessary.

10.1039/d2np00058j

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Citations (8)

CCDC 2100345: Experimental Crystal Structure Determination

The Cambridge Structural Database (2021)

Jackson S. Henneveld Selena C. L. Gilmer Nigel T. Lucas Bill C. Hawkins

10.5517/ccdc.csd.cc28hl2g

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Seven-membered rings

Progress in heterocyclic chemistry (2021)

Alex C. Bissember Christopher J. T. Hyland Steven M. Wales Bill C. Hawkins Jack L.‐Y. Chen

10.1016/b978-0-323-98410-2.00016-3

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Citations (1)

CCDC 2052141: Experimental Crystal Structure Determination

The Cambridge Structural Database (2021)

Sinan Gai Jackson S. Henneveld Andrew P. Cording Michael P. Badart Nigel T. Lucas

10.5517/ccdc.csd.cc26wf3n

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CCDC 2052139: Experimental Crystal Structure Determination

The Cambridge Structural Database (2023)

Sinan Gai Jackson S. Henneveld Andrew P. Cording Michael P. Badart Nigel T. Lucas

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.

10.5517/ccdc.csd.cc26wf1l

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Dipole‐Transmissive 1,3‐Dipolar Cycloadditions for the Rapid Construction of Polycyclic N‐Heterocycles: Synthetic and Mechanistic Investigations

Chemistry - A European Journal (2023)

Jackson S. Henneveld Farshad Shiri Alireza Ariafard Nigel T. Lucas Alex C. Bissember

The investigation of distinctive dipole-transmissive dipolar cycloaddition (DTDC) methodology and the formalisation of this concept is reported. A DTDC procedure was able to be developed by taking advantage of the structural complementarity of azide and diazoalkane 1,3-dipoles. Intramolecular azide-alkene 1,3-DCs followed by spontaneous dipole transmission upon work-up furnished intermediate α-diazoisoindole and α-diazoisoquinoline substrates bearing the key secondary diazoalkane 1,3-dipole. N-Derivatisation of the intermediate α-diazoisoindole and α-diazoisoquinolines with a tethered secondary dipolarophile followed by a subsequent 1,3-DC allowed for rapid construction of a range of functionalised polycyclic N-heterocycles. Integrated experimental and theoretical studies established requirements for product formation and revealed the likely mechanistic basis of divergent reactivity observed.

Alkene

10.1002/chem.202301254

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Citations (4)

CCDC 2059015: Experimental Crystal Structure Determination

The Cambridge Structural Database (2021)

Sinan Gai Jackson S. Henneveld Andrew P. Cording Michael P. Badart Nigel T. Lucas

10.5517/ccdc.csd.cc273kvs

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CCDC 2100346: Experimental Crystal Structure Determination

The Cambridge Structural Database (2021)