A quantitative chemical analysis of total cholesterol, bilirubin, calcium, inorganic phosphate and iron of three types of biliary calculi (cholesterol, pigment and mixed) of 40 gall stone former was carried out and correlated to with those of there sera. A moderately positive correlation for inorganic phosphate, Ca2+ and Fe2+ content of sera and calculi of cholesterol stone patient was found. A Good positive correlation for total cholesterol, a moderately positive correlation for bilirubin and iron but no correlation for inorganic phosphate and calcium content of sera and calculi of pigment stone patient was observed. A good moderately positive correlation for iron but no correlation for total cholesterol, bilirubin, inorganic phosphate and Ca2+ content of sera and calculi of stone patient was found.
The profile of the study provides an elaborate analyses of judicial verdicts delivered by the High Courts and Supreme Court of India in cheque dishonour cases. The operation of certain provisions of the law of Criminal Procedure Code are excluded for the courts to take cognizance of offence under section 142 of the Negotiable Instrument Act, 1881.
A solid lipid Microparticle reaches to the target site at controlled rate and show controlled release for better therapeutic result. This drug delivery system are prepare to obtained prolonged sustained or controlled drug delivery, to improves bioavailability, to enhance stability and to reduce toxic effects follows with target drug at specific site. The solid lipid micro particles of curcumin were prepared in a view to achieve high permeability of curcumin in brain through blood-brain-barrier. The solid lipid microspheres are prepared by hot melts microencapsulation technique was used to formulate solid lipid microspheres. Twelve formulations were prepared by varying concentration of surfactants (span 20, span 60, span 80 and Tween 80). The developed formulation were subjected to various parameter such as the particle size, % entrapment efficiency, production yield, % cumulative release, percentage yield and drug loading. Based upon highest entrapment efficiency, drug release and % cumulative release the F3 formulation was considered as the best formulation. The prepared microsphere were subjected to different evaluation parameter such as melting point, thin layer chromatography, solubility, FTIR, compatibility study and In-vitro drug release. The developed formulation shows spherical and smooth surface. The % drug release of F3 formulation was found to be 86.23% after 12 hr.
Genetically differing, conventional, naturally growing, traditional, or primordial food crops were nutritionally rich especially in micronutrients. These days, micronutrients quantity from the food crops has been dropped and even a few have been missing from the edible crops since the farmers prefer to have more crop production and to make more returns. Further, the farmers are paying more attention to the application of macro elements in the soil, ignoring the importance of microelements. Lessened quantity of micronutrients in soils results in food crops deficient in micronutrients, which ultimately results in ‘hidden hunger’ in humans. To overcome these problems, microbial-facilitated building up of micronutrients is a novel and assuring approach for higher accessibility of nutrients to crop plants and this approach is known as biofortification. Microbial approach is receiving more consideration to upsurge phyto-obtainability of micronutrients, specifically iron and, zinc in the millet crops. Exploitation of distinct types of potential microbes (bacteria and fungi) that encourage plant growth and development is befitting as an efficient and effective tactic to replace manmade fertilizers, supplements, and pesticides. Beneficial microbes use various mechanisms to mobilize the micronutrients from soil to plants such as organic acids production, acidification, metal chelation, and exchange reactions. This review focuses on millets importance and managing the uptake and mobilization of micronutrients (iron/zinc) using microbial approach.
Prevalence of pathogenic microorganisms in the rhizosphere causing infectious diseases in plants and humans has increased considerably due to a high content of nutrients. Such pathogenic infections are of huge concern in agriculture, health care, and medical arenas. Rhizosphere microbiome is a “microbial hotspot,” not only for pathogenic microorganism but also for unlimited beneficial microorganisms. Therefore, this microbiome has immense potential in the shaping of earth from natural vegetation to the intense agricultural production to human health. Rhizosphere microorganism from unexplored habitats is a promising approach to overcome the escalating threat of such pathogenic infections. Hence, efforts are being made to isolate more and more rhizobacteria that are beneficial for better plant productivity and for treating human diseases. Thus, present review highlights and discusses the available literature on beneficial/pathogenic microorganisms belonging to rhizosphere and their impact on plants and human diseases. Furthermore, it sheds light on how this novel knowledge helps in deriving maximum benefits out of this naturally occurring population for the betterment of plant and human health.