Chen Xie

Nanjing University of Posts and Telecommunications

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Jianlin Han

Nanjing Forestry University

Yi Pan

Nanjing University

Haibo Mei

Nanjing Forestry University

Vadim A. Soloshonok

Ikerbasque

Kanyi Pu

Nanyang Technological University

Quli Fan

The Synergetic Innovation Center for Advanced Materials

Lingmin Wu

South China University of Technology

Wen Zhou

Nanjing University of Posts and Telecommunications

Xu Zhen

Canadian Forest Service

Yuyan Jiang

Beijing Institute of Technology

Cooperative Institutions

Nanjing University

Nanjing University of Posts and Telecommunications

Nanjing Drum Tower Hospital

The Synergetic Innovation Center for Advanced Materials

Chinese Academy of Sciences

Nanyang Technological University

Sun Yat-sen University

Nanjing Medical University

Fudan University

Sichuan University

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Organic Nanotheranostics for Photoacoustic Imaging-Guided Phototherapy

Current Medicinal Chemistry (2018)

Houjuan Zhu Chen Xie Peng Chen Kanyi Pu

Phototherapies including photothermal therapy (PTT) and photodynamic therapy (PDT) have emerged as one of the avant-garde strategies for cancer treatment. Photoacoustic (PA) imaging is a new hybrid imaging modality that shows great promise for real-time in vivo monitoring of biological processes with deep tissue penetration and high spatial resolution. To enhance therapeutic efficacy, reduce side effects and minimize the probability of over-medication, it is necessary to use imaging and diagnostic methods to identify the ideal therapeutic window and track the therapeutic outcome. With this regard, nanotheranostics with the ability to conduct PA imaging and PTT/PDT are emerging. This review summarizes the recent progress of organic nanomaterials including nearinfrared (NIR) dyes and semiconducting polymer nanoparticles (SPNs) in PA imaging guided cancer phototherapy, and also addresses their present challenges and potential in clinical applications.

Molecular Imaging

Therapeutic window

Cancer Therapy

Modality (human–computer interaction)

10.2174/0929867324666170921103152

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Citations (24)

ChemInform Abstract: Tandem 1,5‐Migration/Michael Reactions to Prepare Adducts of Pyrazolone Derivatives: Protecting Group Directed Rearrangement.

ChemInform (2013)

Zhijin Lu Chen Xie Jianlin Han Yi Pan

Abstract Reaction of pyrazolines of type (I) with nitroolefins (II) follows the title sequence and affords 4‐substituted‐5‐pyrazolone derivatives.

Pyrazolones

Tandem

Michael reaction

Sequence (biology)

10.1002/chin.201311120

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Citations (0)

Synthesis of self-emulsifiable water-borne epoxy resin

Journal of Wuhan Institute of Technology (2011)

Chen Xie

Acrylic resin

Source

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Citations (0)

Supramolecular Amphiphilic Polymer-Based Micelles with Seven-Armed Polyoxazoline Coating for Drug Delivery

ACS Applied Materials & Interfaces (2017)

Peng Zhang Xiao-Ping Qian Zhengkui Zhang Cheng Li Chen Xie

Supramolecular polymer micelles composed of seven-armed poly(2-methy-2-oxazoline) as the coating and linear poly(dl-lactide) as the core were prepared through synthesizing β-cyclodextrin-terminated poly(2-methy-2-oxazoline) and adamantine-terminated linear poly(dl-lactide), followed by host-guest interaction between β-cyclodextrin and adamantine groups in two polymers and self-assembly in aqueous solution. Dynamic light-scattering measurement showed that the micelles based on supramolecular amphiphilic polymers have the size of 119 nm and were highly stable in salt solution. When the micelles were used as the carrier of cabazitaxel, an antitumor agent for drug-resistant cancers, satisfactory drug loading content and encapsulation efficacy were obtained. In vitro cellular cytotoxicity assays found that cabazitaxel-loaded micelles presented obvious cytotoxicity against taxane-sensitive and -resistant cancer cells. Further in vivo antitumor activity evaluation showed that cabazitaxel-loaded micelles have significantly superior efficacy in inhibiting tumor growth and prolonging survival in tumor-bearing mice compared to that of free paclitaxel and free cabazitaxel.

Supramolecular Polymers

10.1021/acsami.6b14464

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Citations (41)

Grafted semiconducting polymer amphiphiles for multimodal optical imaging and combination phototherapy

Chemical Science (2020)

Chen Xie Wen Zhou Ziling Zeng Quli Fan Kanyi Pu

This review summarizes the applications of grafted semiconducting polymer amphiphiles (SPAs) as multimodal optical nanoagents for cancer imaging and combination phototherapy.

Cancer Imaging

Multimodal therapy

10.1039/d0sc01721c

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Citations (59)

General asymmetric synthesis of 2,2,2-trifluoro-1-(1H-indol-3- and -2-yl)ethanamines

Journal of Fluorine Chemistry (2015)

Lingmin Wu Chen Xie Jie Zhou Haibo Mei Vadim A. Soloshonok

Moiety

Ethylamine

Pyrrole

Diastereomer

10.1016/j.jfluchem.2015.01.001

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Citations (15)

Delivery of doxorubicin in vitro and in vivo using bio-reductive cellulose nanogels

Biomaterials Science (2013)

Hanqing Qian Xin Wang Kangjun Yuan Chen Xie Wei Wu

A methacrylation strategy was used to functionalize carboxymethyl cellulose and prepare redox-sensitive cellulose nanogels which contained disulfide bonds. Dynamic light scattering, zeta potential and electron microscopy were utilized to characterize these nanogels. It was found that these nanogels had a spherical morphology with a diameter of about 192 nm, and negative surface potential. These redox-sensitive nanogels were stable against high salt concentration but de-integrated in the reducing environment containing glutathione. When doxorubicin (DOX) was loaded into the nanogels, a high drug loading content (36%) and a high encapsulation efficiency (83%) were achieved. Confocal laser scanning microscopy and co-localization images showed that DOX-loaded nanogels were internalized by the cancer cells through endocytosis and the DOX could be delivered into the nucleus. Near-infrared fluorescence imaging biodistribution examination indicated that the nanogels could passively target to the tumor area by the EPR effect and had a significantly prolonged circulation time. In vivo antitumor evaluation found that DOX-loaded nanogels exhibited a significantly superior antitumor effect than the free DOX by combining the tumor volume measurement and the examination of cell apoptosis and proliferation in tumor tissues.

Nanogel

Biodistribution

10.1039/c3bm60176e

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Citations (62)

A Renal-Clearable PEGylated Semiconducting Oligomer for the NIR-II Fluorescence Imaging of Tumor

ACS Applied Bio Materials (2022)

Wenheng Shi Shanchao Diao Tingting Liang Xuheng Zhang Zixin Guo

Second near-infrared window fluorescence imaging (NIR-II FI) has attracted tremendous attention in bioimaging. Until now, most probes for NIR-II FI are nanomaterials that are metabolized via hepatobiliary metabolism. Such a metabolic pathway may take several months, causing long-term toxicity. Herein, we design and synthesize a renal-clearable PEGylated semiconducting oligomer (PSO) for the NIR-II FI of tumor. PSO is composed of a semiconducting oligomer (SO) backbone as an NIR-II fluorescence reporter and four poly(ethylene glycol) (PEG) side chains as water-soluble enhancers. PSO can emit an NIR-II fluorescence signal with the maximum emission at 1000 nm under the excitation of 808 nm light. PSO shows good biocompatibility and can be partially cleared out of body via renal clearance. PSO can be utilized for the NIR-II FI of tumor as it can effectively accumulate into tumor.

Oligomer

Clearance

Biocompatibility

10.1021/acsabm.2c00682

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Citations (8)

Iodine‐Rich Semiconducting Polymer Nanoparticles for CT/Fluorescence Dual‐Modal Imaging‐Guided Enhanced Photodynamic Therapy

Small (2020)

Wen Zhou Ying Chen Yutao Zhang Xiaoyan Xin Rutian Li

Abstract Photodynamic therapy (PDT) is a promising technique for cancer therapy, providing good therapeutic efficacy with minimized side effect. However, the lack of oxygen supply in the hypoxic tumor site obviously restricts the generation of singlet oxygen ( 1 O 2 ), thus limiting the efficacy of PDT. So far, the strategies to improve PDT efficacy usually rely on complicated nanosystems, which require sophisticated design or complex synthetic procedure. Herein, iodine‐rich semiconducting polymer nanoparticles (SPN‐I) for enhanced PDT, using iodine‐induced intermolecular heavy‐atom effect to elevate the 1 O 2 generation, are designed and prepared. The nanoparticles are composed of a near‐infrared (NIR) absorbing semiconducting polymer (PCPDTBT) serving as the photosensitizer and source of fluorescence signal, and an iodine‐grafted amphiphilic diblock copolymer (PEG‐PHEMA‐I) serving as the 1 O 2 generation enhancer and nanocarrier. Compared with SPN composed of PEG‐ b ‐PPG‐ b ‐PEG and PCPDTBT (SPN‐P), SPN‐I can enhance the 1 O 2 generation by 1.5‐fold. In addition, SPN‐I have high X‐ray attenuation coefficient because of the high density of iodine in PEG‐PHEMA‐I, providing SPN‐I the ability of use with computed tomography (CT) and fluorescence dual‐modal imaging. The study thus provides a simple nanotheranostic platform composed of two components for efficient CT/fluorescence dual‐modal imaging‐guided enhanced PDT.

Nanocarriers

Fluorescence-lifetime imaging microscopy

10.1002/smll.201905641

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Citations (53)

Cinchona Alkaloid‐catalyzed Asymmetric Direct Mannich Reaction of Malononitrile to Imine for Synthesis of β‐Amino Malononitrile

Chinese Journal of Chemistry (2012)

Zhijin Lu Chen Xie Wei Zhou Zhiqiang Duan Jianlin Han

Abstract The first direct asymmetric Mannich reaction of malononitrile to N ‐Boc‐protected imines has been developed with cinchona alkaloid as catalyst. The procedure could tolerate a relatively wide range of substrates, and results in excellent yields and good enantioselectivities even in the presence of only 1 mol% of catalyst loading. The present work provides an easy access to β ‐amino malononitrile derivatives.

Cinchona

Imine

Mannich reaction

10.1002/cjoc.201200586

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Citations (12)