S. Pandey

Pennsylvania State University

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Hernán Ceballos

International Center for Tropical Agriculture

G. Granados

Centro Internacional de Mejoramiento de Maíz Y Trigo

Luis Narro

International Center for Tropical Agriculture

Waquar Akhter Ansari

Marwadi University

G. Srinivasan

Tamil Nadu Agricultural University

E. B. Knapp

Centro Internacional de Mejoramiento de Maíz Y Trigo

S. K. Vasal

Centro Internacional de Mejoramiento de Maíz Y Trigo

J. Duque‐Vargas

Archana Durairaja

Otto-von-Guericke University Magdeburg

Juan Carlos Pérez

Institución Universitaria Colegio Mayor de Antioquia

Cooperative Institutions

Centro Internacional de Mejoramiento de Maíz Y Trigo

Beaumont Hospital, Royal Oak

Beaumont Health

Tribhuvan University Teaching Hospital

Oakland University

Banaras Hindu University

International Center for Tropical Agriculture

Beaumont Hospital, Troy

Tribhuvan University

Motilal Nehru Medical College

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Long‐Term Selection in Plants in the Developing World

Plant breeding reviews (2003)

John W. Miles S. Pandey

10.1002/9780470650288.ch2

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Citations (4)

Response to Selection for Tolerance to Acid Soils in a Tropical Maize Population

Crop Science (1993)

G. Cranados S. Pandey Hernán Ceballos

Soil acidity reduces maize ( Zea mays L.) yields on about eight million hectares in developing countries. We report on response to selection for tolerance to soil acidity, using an altered version of modified ear‐to‐row (MER) and full‐sib (FS) selection. In the MER selection, 120 half‐sib (HS) families were evaluated under 45 and 80% AI saturation. One to three ears from each of the best 30% of the families were selected each cycle. After 16 cycles of MER selection, FS selection was initiated. Two hundred and fifty FS families were evaluated at five to six acid (ASEs) and one normal soil environments (NSE) the best 25% were selected each cycle. Cycles 2, 4, 6, 8, 10, 12, and 14 of MER and 0, 1, and 2 of FS selection were evaluated in three to nine replications at six ASEs and five NSEs during 1990–1991. Across the 11 environments, gain from selection in yield averaged 40 kg ha −1 cycle −1 (1.49**%) with MER and 250 kg ha −1 cycle −1 v (8.10*%) with FS selection. Across the six ASEs, yield improvements of 40 kg ha −1 cycle −1 (1.99**%) with MER and 310 kg ha −1 cycle −1 (13.96**%) with FS selection were obtained. Yield also improved across the five NSEs by 50 kg ha −1 cycle −1 (1.10**%) with MER and 150 kg ha −1 cycle −1 (3.31%) with FS selection. Results indicate that tolerance to soil acidity can be improved with recurrent selection and that the progress will be higher with a system more efficient at reducing the experimental error and genotype ✕ environment interaction.

10.2135/cropsci1993.0011183x003300050012x

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Citations (72)

EVALUATION OF MELONS AND INDIGENOUS CUCUMIS SPP. GENOTYPES FOR DROUGHT TOLERANCE

Acta Horticulturae (2013)

S. Pandey Waquar Akhter Ansari Arun Jha K.V. Bhatt Bijendra Singh

Climate change affects the performance of many crop plants worldwide. Abiotic stress such as moisture stress is one of the important factors, reducing average yield of major vegetable crops by more than 50%. The present study was planned to find out simple and precise field techniques to detect moisture stress tolerant genotypes of melons and Cucumis spp. A total of 121 genotypes of melons and Cucumis spp. including 43 lines of Cucumis callosus, 19 lines of Cucumis melo, 29 lines of Cucumis sativus, 27 lines of Cucumis melo var. momordica, 2 lines of Cucumis melo var. utilissimus and 1 line of Cucumis melo var. chate, were planted in two sets during the summer season of 2010, at IIVR, Varanasi, in a randomised block design with two replications. Both sets were kept under regular irrigation and normal agricultural practices were applied during the initial 30 days. After 30 days, irrigation in one set was withdrawn. Irrigation, however, continued with the other set as per requirement and observations were recorded. The treatment set which was exposed to moisture stress, was re-irrigated after one month of stress exposure. During the period of water withdrawal accessions were evaluated using a five point scale (1-5) and seven horticultural parameters, which included fruit count/plant, fruit weight, yield/plant (g), yield/ha (q), fruit length (cm), fruit width (cm) and vine length (cm) in both sets of experiment. The drought tolerance efficiency (DTE) was calculated using both sets of data. Based on the observations above, 5 genotypes, which include 2 lines Cucumis callosus (SKY/DR/RS-101 and AHK-200), 1 line each of Cucumis melo (SC-15), Cucumis melo var. momordica (VRSM-58) and Cucumis melo var. chate (arya), were identified as drought tolerance genotypes based on DTE % and yield parameters. These lines of melons and Cucumis spp. should be included in long term breeding programs because they have high moisture stress tolerance efficiency.

Cucumis

Melon

10.17660/actahortic.2013.979.35

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Citations (8)

Tolerancia a suelos ácidos en poblaciones tropicales de maíz del CIMMYT

Agronomía Mesoamericana (2016)

Hernán Ceballos S. Pandey E. B. Knapp J. V. Duque

Currently, five tropical maize populations from CIMMYT are being bred for tolerance to acid soils through a full-sib recurrent selection scheme. Three cycles of selection from each population were evaluated in a split-plot design, with a varied number of replications under five environments (with normal soils, and the remaining four with varying degrees of soil stress). The observed genetic gains from these populations were highly significant: 4.72 % per cycle at all environments, 4.90% per cycle in acid soil environments (LSA), and 4.21 % per cycle for the normal soil location (LNA). The results suggest adequate genetic variability and high heritability for tolerance to soil acidity. In comparative trials, these populations yielded an average of 2.29 and 6.25 t/ha in the three LSA and two LNA environments, respectively. Under the same environments, the controls used (Tuxpeño, Pool 26 and Suwan-1) yielded an average of 1.28 and 5.56 t/ha.

10.15517/am.v5i0.25070

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Citations (1)

Tropical Maize and Heterosis

ASSA, CSSA and SSSA (2013)

S. K. Vasal H. Córdova S. Pandey G. Srinivasan

Hybrid development in tropical maize dates back to the 1940s. Any germplasm can be used for hybrid development but its effectiveness will depend on its ability to provide inbreds with acceptable frequency and with superior agronomic performance. Breeding efforts in the early 1960s and 1970s emphasized formation of populations disregarding heterotic patterns and combining ability. Occurrence of stresses such as downy mildew in Asia, stunt complex in Central America, Maize Streak Virus in Africa, and soil-acidity tolerance in South America has changed focus of germplasm development and improvement strategies. Characterization of maize germplasm for combining ability and heterotic patterns is important in hybrid breeding. Several useful heterotic patterns have been described by Wellhausen and Goodman. Testers are essential to the success of a hybrid breeding program. At present, all types of materials including population(s), synthetics, hybrids, and inbreds are used as testers.

Germ plasm

10.2134/1999.geneticsandexploitation.c34

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Citations (19)

A Drd1-cre mouse line with nucleus accumbens gene dysregulation exhibits blunted fentanyl seeking

bioRxiv (Cold Spring Harbor Laboratory) (2025)

Annalisa Montemarano Logan D. Fox Farrah A Alkhaleel Alexandria E Ostman Hajra Sohail

The synthetic opioid fentanyl remains abundant in the illicit drug supply, contributing to tens of thousands of overdose deaths every year. Despite this, the neurobiological effects of fentanyl use remain largely understudied. The nucleus accumbens (NAc) is a central locus promoting persistent drug use and relapse, largely dependent on activity of dopamine D1 receptors. NAc D1 receptor-expressing medium spiny neurons (D1-MSNs) undergo molecular and physiological adaptations that contribute to negative affect during fentanyl abstinence, but whether these neuroadaptations also promote fentanyl relapse is unclear. Here, we obtained Drd1-cre 120Mxu mice to investigate D1-dependent mechanisms of fentanyl relapse. We serendipitously discovered this mouse line is resistant to fentanyl seeking, despite similar intravenous fentanyl self-administration, and greater fentanyl-induced locomotion, compared to wildtype counterparts. In drug naïve mice, we found Drd1-cre 120Mxu mice have elevated D1 receptor expression in NAc, alongside increased expression of MSN marker genes Chrm4 and Penk. We show Drd1-cre 120Mxu mice have increased sensitivity to the D1 receptor agonist SKF-38393, and exhibit divergent expression of MSN markers, opioid receptors, glutamate receptor subunits, and TrkB after fentanyl self-administration that may underly blunted fentanyl seeking. Finally, we show fentanyl-related behavior is unaltered by chemogenetic manipulation of D1-MSNs in Drd1-cre 120Mxu mice. Conversely, chemogenetic stimulation of putative D1-MSNs in wildtype mice recapitulated the blunted fentanyl seeking of Drd1-cre 120Mxu mice, supporting a role for aberrant D1-MSN signaling in this behavior. Together, our data uncover alterations in NAc gene expression and function with implications for susceptibility and resistance to developing fentanyl use disorder.

Line (geometry)

10.1101/2025.02.14.638324

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Nasal Administration of Orexin a Partially Rescues Dizocilpine-Induced Cognitive Impairments in Female C57BL/6J Mice

Archana Durairaja S. Pandey Evelyn Kahl Markus Fendt

Sex difference has been reported in several behavioural endophenotypes of neuropsychiatric disorder in both rodents and humans. However, sex difference in cognitive symptoms associated with neuropsychiatric disorders has not been studied in detail. In this study, we induced cognitive impairment using the NMDA receptor antagonist, dizocilpine (MK-801), in male and female C57BL/6J mice and performed a visual discrimination task in an automated touchscreen system. We found that discrimination performance decreased with increased doses of MK-801 in both sexes. However, female mice showed stronger deficit in discrimination performance than the male mice especially after administration of low (0.01 mg/kg) and high (0.15 mg/kg) doses of MK-801. Furthermore, we tested if administration of orexin A, orexin-1 receptor antagonist SB-334867 or orexin-2 receptor antagonist EMPA rescued MK-801 (0.15 mg/kg) induced cognitive impairment in visual discrimination i. We found that nasal administration of orexin A partially rescued the cognitive impairment induced by MK-801 in females but not in males. Taken together, our data show that female C57BL/6J mice are more sensitive compared to males to some doses of MK-801 in discrimination learning task and that orexin A partially rescues this cognitive impairment in females.

Dizocilpine

10.2139/ssrn.4385370

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S333 How Reliable Is Circulating Tumor DNA in Detecting Disease Progression or Regression of Non-Colorectal Gastrointestinal Cancers

The American Journal of Gastroenterology (2022)

Bipin Ghimire Ujjwal Karki Emma Herrman S. Pandey Bana Antonios

Introduction: Circulating tumor DNA are short DNA sequences of tumor cells shed into the systemic circulation. Post-operative ctDNA positivity has been studied as a potential marker for disease recurrence, however, dynamic changes in its level and immediate correlation with imaging have not been well described. Methods: We conducted a retrospective study including adult patients with non-colorectal gastrointestinal (GI) cancer. We evaluated the correlation of ctDNA with imaging studies to detect disease progression or regression. Eighteen patients, with 33 ctDNA samples were included. Results: Out of the 18 patients, five had pancreatic, three each had hepatocellular and cholangiocarcinoma, two each had anal cancer and neuroendocrine tumor, and one each had gastric, small bowel, and GI malignancy of unknown primary. Among the patients, 50% were male, and the median age at diagnosis was 64 years. 72.2% of the patients had advanced disease (stage III/IV), and only 22.2% had a predisposing condition leading to malignancy. Our primary endpoint, the correlation of single positive ctDNA results with imaging showing either progression or residual disease, showed a sensitivity of 60% and specificity of 100%. Secondarily, serial ctDNA was analyzed in ten patients with at least two ctDNA test results. This revealed a sensitivity of 80% and specificity of 100% for up-trending ctDNA values to detect progression, down-trending to detect regression, and persistent negative results to detect the absence of disease. This calculated sensitivity was lower than our separate analysis of colorectal cancer, where the sensitivity of single and serial ctDNA was 84.8% and 92.9%, respectively. The specificity, however, was 100% in both cancer groups. The positive ctDNA results detected disease progression with a median lead-time of 44 days compared to imaging. Conclusion: Colorectal cancer is the most studied malignancy in regards to the use of circulating tumor DNA as a marker of tumor recurrence. Similar studies in non-colorectal GI cancers are lacking. However, limited studies have shown some promising results for the use of post-operative ctDNA. The test’s sensitivity in our study was inferior compared to colorectal cancer, but given high specificity and improvement in sensitivity with serial analysis, ctDNA can be a valid way to monitor disease progression or regression in non-colorectal GI cancers. Further clinical studies are required to prove its utility in the reliable detection of immediate changes in disease status.

Surrogate endpoint

Circulating tumor DNA

Gastrointestinal cancer

10.14309/01.ajg.0000857972.60639.ba

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Citations (0)

Neurophysiological Markers of Internet Gaming Disorder: A Literature Review of Electroencephalography Studies

Cureus (2021)

Saima Kashif S. Pandey Zain I Warriach

Pathological online gaming is a relatively newer psychiatric disorder. It is the second behavioral addiction (after internet gambling disorder) included in the Diagnostic and Statistical Manual of Psychiatric Disorders (DSM), 5th edition as "Internet Gaming Disorder" (IGD). Recent research is showing high morbidity associated with IGD, thus encouraging researchers to find valid and reliable biomarkers of IGD. So that, early diagnosis and proper treatment could limit the high disability level accompanying excessive online gaming. As electroencephalography (EEG) is a non-invasive and relatively easily available diagnostic technique, we aimed at collecting EEG studies that investigated EEG changes associated with IGD, with a specific focus on finding diagnostic and predictive neurophysiological biomarkers of IGD. We searched PubMed and Google Scholar for EEG studies of IGD. We eliminated those EEG studies that were not focused on finding biomarkers. Scale for the Assessment of Narrative Review Articles (SANRA) is followed in the writing of this review article. Our results showed that increased slow-wave resting-state activity and reduced P300 and N100 can serve as useful IGD diagnostic markers of IGD. Moreover, increased resting-state theta activity can be a predictive biomarker of IGD. Lastly, increased late low potentials (LLPs) can be specific trait markers of cue-induced cravings in IGD.

Immunoglobulin D

Endophenotype

Narrative review

10.7759/cureus.17866

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Citations (6)

S2000 Colonoscopy-Induced Transient Mobitz Type 1 Block

The American Journal of Gastroenterology (2022)

Inayat Gill S. Pandey Atulkumar Patel

Introduction: Propofol is a commonly used anesthetic in endoscopic procedures. It can prolong the atrioventricular (AV) conduction through vagal stimulation leading to AV block. We report a unique case of a previously healthy patient undergoing a routine screening colonoscopy who developed a Mobitz type 1 block during the procedure, in which propofol was the sole agent used for sedation. Case Description/Methods: A 74-year-old female with a medical history of diverticulosis and a family history of colon cancer in her first-degree relative presented for a routine colonoscopy performed under monitored supervised propofol sedation. During the final phase of the colonoscopy which was performed with minimal air insufflation, she was observed to have a transient 2:1 heart block mixed with periods of 3:2 heart block on the monitor. After the procedure was completed, she reported no cardiac or neurological symptoms. Review of an electrocardiogram strip showed lengthening of the PR interval consistent with Wenckebach (Mobitz type 1 block; Figure. This resolved post procedure. All labs were within normal limits. Prior to this procedure, she had no cardiac history nor was she on any medications. She was referred for a formal cardiology evaluation which included a 14-day Holter monitor showing 22 asymptomatic episodes of supraventricular tachycardia with longest being 26. No treatment was initiated. She also underwent an echocardiogram showing an ejection fraction of 75%, with a normal left ventricle. The incident was deemed to be a vagal affect due to the probe being in the colon/rectum and the effects of propofol. She has not had any recurrences of the Wenckebach phenomenon on subsequent electrocardiograms and continues to remain asymptomatic. Discussion: Propofol can prolong the AV conduction system leading to a heart block even in patients without any cardiac history. The suggested mechanism is hypervagal stimulation causing slow sinus rate, prolongation of stimulus to the bundle of His interval, lengthening of the Wenckebach cycle and the effective refractory period. While air distention in the stomach or colon can also result in a vasovagal reaction and bradycardia, cases of nodal block in this situation are extremely rare. This case demonstrates that in addition to expected vasovagal bradycardia, nodal block is a rare possibility and hence the need for close continuous cardiac monitoring during endoscopy.Figure 1.: Lengthening of the PR interval consistent with Wenckebach (Mobitz type 1 block).

10.14309/01.ajg.0000864640.48944.3c

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Citations (1)