Objective To explore the effect of oxytocin on uterine fibroids treated by ultrasound ablation. Methods Eighty-two single points in 29 uterine fibroids from 26 patients were sonicated with magnetic resonance imaging guided by high intensity focused ultrasound before and after using oxytocin. The required total energy, sonication time required to reach 60 ℃ and the acoustic energy for increasing 1 ℃ of temperature at the single point before and after using oxytocin were compared. Results Before intravenous infusion of oxytocin, the average total sonication energy required to reach 60 ℃ was (5320 ±910) J and it took (21 ±20) seconds for sonicating a single point, the energy required for increasing 1 ℃ was (255 ± 302) J. In contrast, after intravenous infusion of oxytocin, the average total sonication energy required to reach 60 ℃ was (2890 ±325) J, and it took (12 ±7) seconds for sonicating a single point, the energy required for increasing 1 ℃ was ( 126 ± 94 ) J. Those three index all reached statistical difference ( P = 0.002, P = 0.001, P= 0.002, respectively). Conclusion It seemed that Oxytocin could significantly decrease the energy required for ablating uterine fibroids, shorten treatment time and improve the treatment efficiency.
Key words:
Uterine neoplasms; Leiomyoma; Ultrasonic therapy; Catheter ablation; Oxytocin; Magnetic resonance imaging
Objective To investigate the accuracy and efficacy of MRI thermometry during high intensity focused ultrasound (HIFU) exposure. Methods HIFU was applied on bovine liver tissue in vitro, and then the necrosis square of MRI T-Map and practical tissue was compared, HIFU was also applied to expose the tissue-mimicking phantom, and then the temperature measured by MRI and optical fiber temperature sensor was compared to verify the accuracy of MRI thermometry. Results The probability for necrosis square of T-Map statistically different from the necrosis square of the practical tissue was 25% (P0. 05 ) ; When the temperature change was less than 1℃/s, the result of MRI thermometry was comparatively consistent with the optical fiber sensor, their mean difference was less than 2. 6℃, while for the rapid temperature change, the mean difference was more than 5. 0℃. Conclusion T-map of MRI can provide some information for necrosis of target area, but the result is not reliable enough, and the accuracy of MRI thermometry is need to be improved.
Objective To explore the relationship between therapeutic dosage of ultrasound ablation in treatment of uterine fibroids and imaging characteristics of bloody supply of uterine fibroids by color Doppler ultrasound imaging. Methods One hundred and forty-two patients with 168 fibroids were treated by ultrasound ablation. Before treatment, bloody supply of fibroids were classified into grade 0 -4 by ultrasonography. Three patients lost follow-up with contrast MRI exam within 1 month after treatment, so 165 fibroids were enrolled in this study. Bloody supplies were 9 fibroids in grade 0, 34 fibroids in grade 1, 35 fibroids in grade 2, 55 fibroids in grade 3 and 32 fibroids in grade 4. After 1 month treatment, the treated area without blood supply and ratio of ablation were measured by contrast MRI to evaluate the efficacy of thermal ablation and compare status of blood supple based different therapeutic dosage. According to International Reditherapy for Society ( SIR ) standard, adverse effect and score of pain were evaluated. Results ( 1) Ratio of ablation based; ratios of ablation were 79% in grade 0, 89% in grade 1, 92% in grade 2, 86% in grade 3, 71% in grade 4. It reached statistical difference when blood supply of grade 0 compared with those of grade 2 and 3 (P ＜ 0. 05 ) and blood supply of grade 4 compared with those of grade 1, 2, 3 ( P ＜ 0. 05). (2) Factor of energy efficiency:factor of energy efficiency were 13.19 J/mm3 in degree 0, 9. 54 J/mm3 in degree 1, 12. 91 J/mm3 in degree 2, 17. 83 J/mm3 in degree 3 and 28. 10 J/mm in degree 4. Factor of energy of ablation in degree 4 was significantly higher than those in degree 1, 2 and 3 blood supply (P ＜ 0. 05). It exhibit the positive relationship between blood supply and factor of energy of ablation ( r = 0. 354 ,P ＜ 0. 01). ( 3 ) Score of pain and adverse effect: nearly 85% ( 120/142 ) patients could tolerate this treatment very well. Those scores of pain were in range of 0 to 4. All patients did not extend their hospitalization and C to F of SIR standard was not recorded. Conclusion blood supply of myoma measured by ultrasound could predict dosage of ultrasound ablation, it could help select indicated well patients.
Key words:
Uterine neoplasms; Leiomyoma; Ultrasonography, doppler, color; Magnetic resonance imaging; Catheter ablation
This study evaluated the psychometric properties of a Chinese form of the Feminist Identity Composite (FIC). A total of 2,334 Chinese adult women completed the scale for this study. In study 1 (n = 875), exploratory analysis indicated six factors, Passive Acceptance, Revelation, Embeddedness/Emanation, Active Commitment, and Synthesis, the latter of which was divided into two subscales (Femininity Synthesis and Autonomous Synthesis). In study 2 (n = 810), confirmatory factor analysis was conducted with a different sample to examine the construct validity of the model obtained in study 1. In study 3 (n = 649), the convergent validity of the FIC was examined via their relationship with willingness to engage in feminist behaviors and attitude toward trans-people. The results indicated that a new measurement with solid conceptual and psychometrically solid properties needs to be developed to assess Chinese women's feminist identity.
The selected fiber optic thermometer and MRI temperature sequence were used to synchronously monitor the temperature change of tissue-mimicking phantom during ultrasound exposure to investigate the feasibility of the MRI thermometry based on PRF theory.The result of experiments illustrates that this method can measure the temperature of target,but the accuracy and velocity of the method should need to improve further.
Abstract The deep neural network is a highly expressive model, which plays an extremely critical role in modern artificial intelligence applications. Adversarial samples can change the prediction results of neural networks by imposing imperceptible perturbations on the original images, which brings new challenges to deep learning. In this paper we summarize the methods of generating adversarial samples in recent years, intuitively feel the development of adversarial samples from the time of publication, and briefly classify them from the perspective of algorithm principles. At the same time, for practical applications, the advantages and disadvantages of the algorithm are analyzed and summarized, and the conditions for the algorithm to be suitable for application are proposed: no need to know the specific structure of the algorithm, high quality of the adversarial samples and convenient migration. The analysis points out that among the typical methods, MI-FGSM, ONE-PIXEL, and methods using GAN are more practical and worthy of further study.
Objective
To investigate the application value of magnetic resonance imaging (MRI) in the classification diagnosis of rectal mucinous adenocarcinoma.
Methods
The retrospective and descriptive study was conducted. The clinical data of 74 patients with rectal mucinous adenocarcinoma who were admitted to Chongqing Traditional Chinese Medicine Hospital from July 2009 and February 2019 were collected. There were 40 males and 34 females, aged (46±8)years, with a range from 32 to 82 years. Among the 74 patients, 41 were simple mucinous adenocarcinoma, 26 were partial mucinous adenocarcinoma, and 7 were focal or small foci mucinous adenocarcinoma. All patients underwent MRI plain scan and dynamic enhanced scan. Observation indicators: (1) morphology of rectal mucinous adenocarcinoma; (2) the lesion margin of rectal mucinous adenocarcinoma; (3) the value of apparent diffusion coefficient (ADC) of rectal mucinous adenocarcinoma; (4) internal enhancement features of rectal mucinous adenocarcinoma; (5) timesignal intensity curve of rectal mucinous adenocarcinoma. Measurement data with normal distribution were represented as Mean±SD, and count data were described as absolute numbers.
Results
(1) Morphology of rectal mucinous adenocarcinoma: 74 patients had different morphological changes. Among the 41 cases of simple mucinous adenocarcinoma, 22 were oval, 8 were round, and 11 were irregular. Among the 26 patients with partial mucinous adenocarcinoma, 15 were oval, 8 were round and 3 were irregular. Among the 7 patients with focal or small foci mucinous adenocarcinoma, 2 were oval, 1 was round and 4 were irregular. (2) The lesion margin of rectal mucinous adenocarcinoma: the lesion margin of 74 patients was mainly unclear and irregular. Among the 41 cases of simple mucinous adenocarcinoma, 32 had unclear and irregular margin, 7 had clear margin, and 2 had unclear margin combined with fissure. Among the 26 cases of partial mucinous adenocarcinoma, 20 had unclear margin combined with fissure, 5 had unclear margin and irregular margin, and 1 had clear margin. Among the 7 patients with focal or small foci mucinous adenocarcinoma, 5 had unclear or irregular margin, 1 had unclear or irregular margin, and 1 had clear margin. (3) The value of ADC of rectal mucinous adenocarcinoma: diffusion weighted imaging of 74 patients showed diffused limited changes. The average ADC value was (1.24±0.23)×10-3 mm2/s of 41 patients with simple mucinous adenocarcinoma, (0.91±0.42)×10-3 mm2/s of 26 patients with partial mucinous adenocarcinoma, and (1.07±0.24)×10-3 mm2/s of 7 patients with focal or small mucinous adenocarcinoma. (4) Internal enhancement features of rectal mucinous adenocarcinoma: 74 patients showed delayed heterogeneous enhancement and marginal enhancement. Among 41 cases of simple mucinous adenocarcinoma, 24 showed delayed heterogeneous enhancement, 17 showed marginal enhancement, and none showed homogeneous enhancement. Among 26 patients with partial mucinous adenocarcinoma, 20 showed marginal enhancement, 6 showed homogeneous enhancement, and none showed heterogeneous enhancement. All the 7 cases of focal or small foci mucinous adenocarcinoma showed heterogeneous enhancement. (5) Timesignal intensity curve of rectal mucinous adenocarcinoma: 74 patients showed mainly outflow type in the timesignal intensity curve. Among the 41 cases of simple mucinous adenocarcinoma, 22 presented progressive curve, 12 presented platform type, and 7 presented outflow type. Among the 26 patients with partial mucinous adenocarcinoma, 17 presented outflow type, 8 presented platform type, and 1 presented progressive type. Among the 7 patients with focal and small forci mucinous adenocarcinoma, 4 presented outflow type, 2 presented platform type, and 1 presented progressive type.
Conclusions
MRI findings show different results for different types of rectal mucinous adenocarcinoma. A correct understanding of the MRI features of different types of rectal mucinous adenocarcinoma is helpful for the classification diagnosis of rectal mucinous adenocarcinoma.
Key words:
Rectal neoplasms; Rectal mucinous adenocarcinoma; Mucous lake; Magnetic resonance imaging
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